1. GPCR/G Protein
    Immunology/Inflammation
  2. CXCR

MSX-122 

Cat. No.: HY-13696 Purity: 99.74%
Handling Instructions

MSX-122 is a novel small molecule and partial CXCR4 antagonist, with potent inhibition of CXCR4/CXCL12 actions (IC50 = 10 nM).

For research use only. We do not sell to patients.

MSX-122 Chemical Structure

MSX-122 Chemical Structure

CAS No. : 897657-95-3

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 92 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
5 mg USD 84 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
10 mg USD 120 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
50 mg USD 420 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
100 mg USD 660 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

MSX-122 is a novel small molecule and partial CXCR4 antagonist, with potent inhibition of CXCR4/CXCL12 actions (IC50 = 10 nM). IC50 value: 10 nM Target: CXCR4/CXCL12 in vitro: MSX-122 is a partial inhibitor of CXCR4/CXCL12 functions. The compelling features of the MSX-122 profile include: (i) potent inhibition of CXCR4/CXCL12 actions (IC50 = 10 nM); (ii) ease of production on a large scale; (iii) effectiveness as an anti-inflammatory and anti-metastatic agent in vivo; and (iv) unique property of blocking homing and recruitment without mobilizing stem cells. MSX-122 blocks invasion and angiogenesis in vitro. in vivo: MSX-122 attenuates colonic damage in mice with experimental colitis.MSX-122 blocks metastasis in an experimental animal model of breast cancer metastasis. MSX-122 blocks metastasis in two more animal models for metastasis.

Clinical Trial
References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 3.4207 mL 17.1034 mL 34.2067 mL
5 mM 0.6841 mL 3.4207 mL 6.8413 mL
10 mM 0.3421 mL 1.7103 mL 3.4207 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

292.34

Formula

C₁₆H₁₆N₆

CAS No.

897657-95-3

SMILES

C1(CNC2=NC=CC=N2)=CC=C(CNC3=NC=CC=N3)C=C1

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Purity: 99.74%

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
MSX-122
Cat. No.:
HY-13696
Quantity: