CXCR4-antagonist-11
CXCR4-antagonist-11 is a CXCR4 antagonist with CXCR4 IC50 values of 68.9 nM and 48.3 nM. CXCR4-antagonist-11 modulates CXCR4 receptor function. CXCR4-antagonist-11 demonstrates high permeability, selectivity against CYP 2D6, and a high hERG index. CXCR4-antagonist-11 shows improved oral exposure in mouse pharmacokinetic studies.
For research use only. We do not sell to patients.
- CAS No.: 2892568-27-1
- Formula: C24H30N4O2
- Molecular Weight:406.52
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
CXCR4 48.3-68.9 nM (IC50) |
In Vitro
CXCR4-antagonist-11 (compound 81) (10 min) potently antagonizes CXCR4 in calcium flux and cAMP assays, exhibits no CYP450 inhibition, and shows high metabolic stability in human and mouse liver microsomes[1].
CXCR4-antagonist-11 has a high hERG therapeutic index and favorable liver microsomal half-life in human and mouse systems[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2892568-27-1
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Molecular Weight 406.52
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Formula C24H30N4O2
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SMILES
O=C1N(CCOC1)C2=CC=CC3=C2C[C@@H](NC3)CN([C@H]4CCCC5=C4N=CC=C5)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CXCR4-antagonist-11 Related Classifications
HY-182909 Related Classifications
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