1. GPCR/G Protein
    Immunology/Inflammation
  2. CXCR
  3. CXCR4 modulator-2

CXCR4 modulator-2 

Cat. No.: HY-146054
Handling Instructions

CXCR4 modulator-2 (compound Z7R) is a highly potent CXCR4 modulator with an IC50 value of 1.25 nM. CXCR4 modulator-2 has acceptable stability (t1/2 = 77.1 min) in mouse serum and exhibits anti-inflammatory activity in mouse edema model.

For research use only. We do not sell to patients.

CXCR4 modulator-2 Chemical Structure

CXCR4 modulator-2 Chemical Structure

CAS No. : 2488943-55-9

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Description

CXCR4 modulator-2 (compound Z7R) is a highly potent CXCR4 modulator with an IC50 value of 1.25 nM. CXCR4 modulator-2 has acceptable stability (t1/2 = 77.1 min) in mouse serum and exhibits anti-inflammatory activity in mouse edema model[1].

IC50 & Target[1]

CXCR4

1.25 nM (IC50)

In Vivo

CXCR4 modulator-2 (10 mg/kg; IP; single dosage) significantly reduces the edema weights (∼50%) in the lesion and decreases the expression of CXCR4s[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: male nude mice (6 weeks, 20 g; subcutaneous injection of 50 μL of λ-carrageenan)[1]
Dosage: 10 mg/kg
Administration: IP; single dosage
Result: Significantly reduced the edema weights (∼50%) in the lesion and decreased the expression of CXCR4s.
Molecular Weight

428.53

Formula

C21H32N8O2

CAS No.
SMILES

O=C(NC1CCN(C(CCN2C=CC3=C2C=NC=C3)=O)CC1)[[email protected]](N)CCCNC(N)=N

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Product Name:
CXCR4 modulator-2
Cat. No.:
HY-146054
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