2. GPCR/G Protein Immunology/Inflammation Anti-infection
  3. CXCR Dengue Virus
  4. DV1

DV1 is a CXCR4 inhibitor with anti-proteolytic properties that specifically blocks the binding of SDF-1α to its receptor. DV1 inhibits the migration of breast cancer cells and enables the targeted delivery of avidin-PLGA nanoparticles to CXCR4-expressing cancer cells. DV1 not only effectively suppresses the progression of metastatic breast cancer in mouse models, but also preferentially accumulates in brain tumor tissues rather than normal brain tissues, showing potential for inhibiting intracranial tumor metastasis. As a humoral immune stimulant, DV1 induces the production of specific IgG, neutralizing antibodies and cellular immune responses, thereby providing the host with protection against lethal challenges. DV1 has been applied to studies on CXCR4-expressing cancers, glioblastoma, dengue fever and other related diseases.

For research use only. We do not sell to patients.

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DV1

DV1 Chemical Structure

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Description

DV1 is a CXCR4 inhibitor with anti-proteolytic properties that specifically blocks the binding of SDF-1α to its receptor. DV1 inhibits the migration of breast cancer cells and enables the targeted delivery of avidin-PLGA nanoparticles to CXCR4-expressing cancer cells. DV1 not only effectively suppresses the progression of metastatic breast cancer in mouse models, but also preferentially accumulates in brain tumor tissues rather than normal brain tissues, showing potential for inhibiting intracranial tumor metastasis. As a humoral immune stimulant, DV1 induces the production of specific IgG, neutralizing antibodies and cellular immune responses, thereby providing the host with protection against lethal challenges. DV1 has been applied to studies on CXCR4-expressing cancers, glioblastoma, dengue fever and other related diseases[1][2][3].

IC50 & Target

SDF-1α-CXCR4

 

In Vitro

DV1 (100 nM; 30 min pre-incubation + 24 h) significantly inhibits SDF-1α-induced migration of human breast cancer MDA-MB-231 cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DV1 Related Antibodies

Cell Migration Assay[2]

Cell Line: MDA-MB-231 human breast cancer cells
Concentration: 100 nM (pre-incubation); 100 nM (transwell culture)
Incubation Time: 30 min (pre-incubation); 24 h (transwell culture)
Result: Significantly inhibited the migration of MDA-MB-231 cells toward the SDF-1α gradient (p < 0.01).
Left over 99% of migrated cells alive after 24 h of treatment.
In Vivo

DV1 (50 μg/kg/day; intracerebroventricular; continuous infusion) delivered via continuous intracerebroventricular infusion in a hyperosmotic solution significantly reduces the incidence of intracranial metastatic breast cancer tumor growth to 54.5% in female athymic nude mice, with preferential accumulation in tumor tissue relative to normal brain tissue[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NCRNU (female, 8 weeks old, intracranial metastatic breast cancer model via right hemisphere intracranial injection of 3×105 luciferase-expressing MDA-MB-231 cells)[2]
Dosage: 50 μg/kg/day
Administration: intracerebroventricular; continuous infusion; starting on tumor cell injection day
Result: Detected roughly twice as many particles in tumor tissue compared to adjacent normal brain tissue, with statistically significant difference.
Reduced tumor incidence to 54.5% (n=22), with statistically significant difference from control's 83% (P=0.0361).
Resulted in smaller average tumor size in mice with tumors, though difference was not statistically significant.
Molecular Weight

2424.85

Formula

C108H170N34O26S2
Sequence

d-(Leu-Gly-Ala-Ser-Trp-His-Arg-Pro-Asp-Lys-Cys-Cys-Leu-Gly-Tyr-Gln-Lys-Arg-Pro-Leu-Pro)-NH2
Sequence Shortening

d-(LGASWHRPDKCCLGYQKRPLP)-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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DV1 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DV1DV 1DV-1CXCRDengue VirusCXC chemokine receptorsC-X-C motif chemokine receptorsDENVU87MG cellsCXCR4intracranial metastatic breast cancerdengue feverbreast cancer cellsglioblastomamouse modelsstromal cell-derived factor 1 alphaavidin-PLGA nanoparticlesBALB/c miceInhibitorinhibitorinhibit

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