1. GPCR/G Protein
    Immunology/Inflammation
  2. CXCR
  3. ATI-2341

ATI-2341 

Cat. No.: HY-P0172
Handling Instructions

ATI-2341 is a potent and functionally selective allosteric agonist of C-X-C chemokine receptor type 4 (CXCR4), which functions as a biased ligand, favoring Gαi activation over Gα13. ATI-2341 activates the inhibitory heterotrimeric G protein (Gi) to promote inhibition of cAMP production and induce calcium mobilization. ATI-2341 is a potent and efficacious mobilizer of bone marrow polymorphonuclear neutrophils (PMNs) and hematopoietic stem and progenitor cells (HSPCs).

For research use only. We do not sell to patients.

Custom Peptide Synthesis

ATI-2341 Chemical Structure

ATI-2341 Chemical Structure

CAS No. : 1337878-62-2

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Description

ATI-2341 is a potent and functionally selective allosteric agonist of C-X-C chemokine receptor type 4 (CXCR4), which functions as a biased ligand, favoring Gαi activation over Gα13. ATI-2341 activates the inhibitory heterotrimeric G protein (Gi) to promote inhibition of cAMP production and induce calcium mobilization. ATI-2341 is a potent and efficacious mobilizer of bone marrow polymorphonuclear neutrophils (PMNs) and hematopoietic stem and progenitor cells (HSPCs)[1][2].

IC50 & Target[1]

CXCR4

194 nM (EC50, in CCRF-CEM cells)

In Vitro

ATI-2341 induces CXCR4- and G protein-dependent signaling, receptor internalization, and chemotaxis in CXCR4-expressing cells. ATI-2341 has an EC50 value of 194 ± 16 nM and an intrinsic activity of 81 ± 4% in CCRF-CEM cells[2].

Molecular Weight

2256.82

Formula

C₁₀₄H₁₇₈N₂₆O₂₅S₂

CAS No.

1337878-62-2

Sequence

1-Oxohexadecyl-Met-Gly-Tyr-Gln-Lys-Lys-Leu-Arg-Ser-Met-Thr-Asp-Lys-Tyr-Arg-Leu

Sequence Shortening

1-Oxohexadecyl-MGYQKKLRSMTDKYRL

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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ATI-2341
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