1337878-62-2
Chemical Structure
ATI-2341
- CAS No.: 1337878-62-2
- Formula:C104H178N26O25S2
- Molecular Weight:2256.82
IUPAC Name: (3R,6S,9R,12S,15R,18S,21R,24S,27R,30S,36S)-3-(((S)-6-amino-1-(((R)-1-(((S)-5-guanidino-1-(((S)-4-methyl-1-oxopentan-2-yl)amino)-1-oxopentan-2-yl)amino)-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)amino)-1-oxohexan-2-yl)carbamoyl)-27-(3-amino-3-oxopropyl)-21,24-bis(4-aminobutyl)-15-(3-guanidinopropyl)-30-(4-hydroxybenzyl)-6-((R)-1-hydroxyethyl)-12-(hydroxymethyl)-18-isobutyl-9,36-bis(2-(methylthio)ethyl)-5,8,11,14,17,20,23,26,29,32,35,38-dodecaoxo-4,7,10,13,16,19,22,25,28,31,34,37-dodecaazatripentacontanoic acid
InChIKey: GHSODUPGXZOPET-VWHBPDKZSA-N
SMILES: OC(C=C1)=CC=C1C[C@@H](C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(O)=O)CC(C)C)=O)=O)NC([C@H](CCCCN)NC([C@H](CC(O)=O)NC([C@H]([C@H](O)C)NC([C@H](CCSC)NC([C@H](CO)NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@H](CCC(N)=O)NC([C@@H](NC(CNC([C@H](CCSC)NC(CCCCCCCCCCCCCCC)=O)=O)=O)CC2=CC=C(C=C2)O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Biological Activity: ATI-2341 is a potent and functionally selective allosteric agonist of C-X-C chemokine receptor type 4 (CXCR4), which functions as a biased ligand, favoring Gαi activation over Gα13. ATI-2341 activates the inhibitory heterotrimeric G protein (Gi) to promote inhibition of cAMP production and induce calcium mobilization. ATI-2341 is a potent and efficacious mobilizer of bone marrow polymorphonuclear neutrophils (PMNs) and hematopoietic stem and progenitor cells (HSPCs)[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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ATI-2341 | 99.64% | ATI-2341 is a potent and functionally selective allosteric agonist of C-X-C chemokine receptor type 4 (CXCR4), which functions as a biased ligand, favoring Gαi activation over Gα13. ATI-2341 activates the inhibitory heterotrimeric G protein (Gi) to promote inhibition of cAMP production and induce calcium mobilization. ATI-2341 is a potent and efficacious mobilizer of bone marrow polymorphonuclear neutrophils (PMNs) and hematopoietic stem and progenitor cells (HSPCs). | ||||||||||||||||||||
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- [1]. Quoyer J, et al. Pepducin targeting the C-X-C chemokine receptor type 4 acts as a biased agonist favoring activation of the inhibitory G protein. Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):E5088-97. [Content Brief]
- [2]. Tchernychev B, et al. Discovery of a CXCR4 agonist pepducin that mobilizes bone marrow hematopoietic cells. Proc Natl Acad Sci U S A. 2010 Dec 21;107(51):22255-9. [Content Brief]
Keywords
