2. GPCR/G Protein Immunology/Inflammation Neuronal Signaling Membrane Transporter/Ion Channel
  3. CXCR Calcium Channel
  4. IS4

IS4 is a selective CXCR4 competitive antagonist, with an IC50 of 0.65 nM in THP-1 cells and 38.75 nM in Jurkat cells. IS4 is stable in serum and non-cytotoxic. IS4 competitively binds to CXCR4 with CXCL12, thereby inhibiting CXCL12-induced intracellular Ca2+ release and cancer cell migration. IS4 can be used in the research on the prevention of metastasis of breast cancer, prostate cancer, leukemia, and other diseases.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

IS4

IS4 Chemical Structure

CAS No. : 3067986-23-3

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IS4 Related Antibodies

Top Publications Citing Use of Products

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CXCR CXCR1 CXCR2 CXCR3 CXCR4 CXCR7 CXCR6

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

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Description

IS4 is a selective CXCR4 competitive antagonist, with an IC50 of 0.65 nM in THP-1 cells and 38.75 nM in Jurkat cells. IS4 is stable in serum and non-cytotoxic. IS4 competitively binds to CXCR4 with CXCL12, thereby inhibiting CXCL12-induced intracellular Ca2+ release and cancer cell migration. IS4 can be used in the research on the prevention of metastasis of breast cancer, prostate cancer, leukemia, and other diseases[1].

IC50 & Target

CXCR4

 

Molecular Weight

1075.22

Formula

C48H62N14O11S2
CAS No.
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Purity & Documentation
References
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IS4 Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IS43067986-23-3IS 4IS-4CXCRCalcium ChannelCXC chemokine receptorsC-X-C motif chemokine receptorsCa2+ channelsCa channelsInhibitorinhibitorinhibit

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