3067986-23-3
Chemical Structure
IS4
- CAS No.: 3067986-23-3
- Formula:C48H62N14O11S2
- Molecular Weight:1075.22
InChIKey: QIWNNQLPEDNVAZ-OTYGRGGYSA-N
SMILES: O=C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C)C(N[C@H](CSC1=C2C(N(CC#C)C1=O)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC3=CC=CC=C3)C(N[C@@H](CC4=CC=CC=C4)C(N[C@@H](CS2)C(O)=O)=O)=O)=O)=O)=O)=O)C
Biological Activity: IS4 is a selective CXCR4 competitive antagonist, with an IC50 of 0.65 nM in THP-1 cells and 38.75 nM in Jurkat cells. IS4 is stable in serum and non-cytotoxic. IS4 competitively binds to CXCR4 with CXCL12, thereby inhibiting CXCL12-induced intracellular Ca2+ release and cancer cell migration. IS4 can be used in the research on the prevention of metastasis of breast cancer, prostate cancer, leukemia, and other diseases[1].
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IS4 | IS4 is a selective CXCR4 competitive antagonist, with an IC50 of 0.65 nM in THP-1 cells and 38.75 nM in Jurkat cells. IS4 is stable in serum and non-cytotoxic. IS4 competitively binds to CXCR4 with CXCL12, thereby inhibiting CXCL12-induced intracellular Ca2+ release and cancer cell migration. IS4 can be used in the research on the prevention of metastasis of breast cancer, prostate cancer, leukemia, and other diseases. | |||||||||||||||||||||
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