1. GPCR/G Protein
    Immunology/Inflammation
    Anti-infection
  2. CXCR
    HIV
  3. FC131 TFA

FC131 TFA 

Cat. No.: HY-P1104A Purity: 99.87%
Handling Instructions

FC131 TFA is a CXCR4 antagonist, inhibits [125I]-SDF-1 binding to CXCR4, with an IC50 of 4.5 nM. Anti-HIV activity.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

FC131 TFA Chemical Structure

FC131 TFA Chemical Structure

Size Price Stock Quantity
1 mg USD 95 In-stock
Estimated Time of Arrival: December 31
5 mg USD 425 In-stock
Estimated Time of Arrival: December 31
10 mg USD 765 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

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Description

FC131 TFA is a CXCR4 antagonist, inhibits [125I]-SDF-1 binding to CXCR4, with an IC50 of 4.5 nM. Anti-HIV activity[1].

IC50 & Target[1]

125I-SDF-1-CXCR4

4.5 nM (IC50)

HIV

 

Molecular Weight

843.85

Formula

C₃₈H₄₈F₃N₁₁O₈

Sequence

Cyclo[{d-Tyr}-Arg-Arg-{Nal}-Gly]

Sequence Shortening

Cyclo[{d-Tyr}-RR-{Nal}-G]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -80°C 2 years
-20°C 1 year
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (296.26 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1850 mL 5.9252 mL 11.8504 mL
5 mM 0.2370 mL 1.1850 mL 2.3701 mL
10 mM 0.1185 mL 0.5925 mL 1.1850 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (2.46 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (2.46 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (2.46 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

FC131FC 131FC-131CXCRHIVCXC chemokine receptorsC-X-C motif chemokine receptorsHuman immunodeficiency virusInhibitorinhibitorinhibit

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Product Name:
FC131 TFA
Cat. No.:
HY-P1104A
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