1. GPCR/G Protein
    Immunology/Inflammation
  2. CXCR
  3. VUF11207 fumarate

VUF11207 fumarate 

Cat. No.: HY-110318
Handling Instructions

VUF11207 fumarate (Compound 29) is a CXCR7 agonist and a high-potency CXCR7 (pKi of 8.1) ligand that induces recruitment of β-arrestin2 (pEC50 of 8.8) and subsequent internalization (pEC50 of 7.9) of CXCR7.

For research use only. We do not sell to patients.

VUF11207 fumarate Chemical Structure

VUF11207 fumarate Chemical Structure

CAS No. : 1785665-61-3

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10 mg USD 210 Ask For Quote & Lead Time
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Description

VUF11207 fumarate (Compound 29) is a CXCR7 agonist and a high-potency CXCR7 (pKi of 8.1) ligand that induces recruitment of β-arrestin2 (pEC50 of 8.8) and subsequent internalization (pEC50 of 7.9) of CXCR7[1].

IC50 & Target

CXCR7

8.1 (pKi)

Molecular Weight

586.65

Formula

C₃₁H₃₉FN₂O₈

CAS No.

1785665-61-3

SMILES

C/C(CN(C(C1=CC(OC)=C(C(OC)=C1)OC)=O)CCC2N(CCC2)C)=C\C3=C(C=CC=C3)F.OC(/C=C/C(O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (426.15 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7046 mL 8.5230 mL 17.0459 mL
5 mM 0.3409 mL 1.7046 mL 3.4092 mL
10 mM 0.1705 mL 0.8523 mL 1.7046 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.55 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (3.55 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.55 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

VUF11207VUF 11207VUF-11207CXCRCXC chemokine receptorsC-X-C motif chemokine receptorsInhibitorinhibitorinhibit

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Product name:
VUF11207 fumarate
Cat. No.:
HY-110318
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