1. GPCR/G Protein Immunology/Inflammation
  2. CXCR
  3. AZD-5069

AZD-5069 

Cat. No.: HY-19855 Purity: 99.76%
COA Handling Instructions

AZD-5069 is a potent CXCR2 chemokine receptor antagonist, used for caner treatment.

For research use only. We do not sell to patients.

AZD-5069 Chemical Structure

AZD-5069 Chemical Structure

CAS No. : 878385-84-3

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 103 In-stock
Solution
10 mM * 1 mL in DMSO USD 103 In-stock
Solid
1 mg USD 66 In-stock
5 mg USD 99 In-stock
10 mg USD 165 In-stock
25 mg USD 319 In-stock
50 mg USD 495 In-stock
100 mg USD 935 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 7 publication(s) in Google Scholar

Top Publications Citing Use of Products

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Description

AZD-5069 is a potent CXCR2 chemokine receptor antagonist, used for caner treatment.

IC50 & Target[1]

125I-IL-8-CXCR2

 

In Vitro

AZD-5069 (Compound 2) acts as CXCR2 antagonist by inhibition of [125I]-IL-8 binding to human CXCR2 receptors and as inhibitor of GROα-induced Ca2+ flux in human neutrophils loaded with fluo-3 dye[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

476.52

Formula

C18H22F2N4O5S2

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=S(N1CCC1)(NC2=NC(SCC3=CC=CC(F)=C3F)=NC(O[C@H](C)[C@@H](O)CO)=C2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 90 mg/mL (188.87 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0985 mL 10.4927 mL 20.9855 mL
5 mM 0.4197 mL 2.0985 mL 4.1971 mL
10 mM 0.2099 mL 1.0493 mL 2.0985 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  50% PEG300    50% Saline

    Solubility: 12.5 mg/mL (26.23 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  5% DMSO    40% PEG300    5% Tween-80    50% Saline

    Solubility: 2.62 mg/mL (5.50 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.25 mg/mL (4.72 mM); Clear solution

  • 4.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.25 mg/mL (4.72 mM); Clear solution

  • 5.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.25 mg/mL (4.72 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: 99.76%

References
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AZD-5069 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
AZD-5069
Cat. No.:
HY-19855
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