FOXJ1
FOXJ1, which is a forkhead transcription factor, has been previously studied mostly as a ciliary transcription factor. FOXJ1 is essential in multiple physiological processes, especially ciliogenesis, embryonic development, and spontaneous autoimmunity inhibition. FOXJ1 also plays a role in malignancy. FOXJ1 is reduced or hypermethylated in gastric cancer, ovarian cancer, breast cancer, aggressive ependymoma, and choroid plexus tumors, and its decreased expression is associated with poor prognosis, indicating its role as a novel tumor suppressor. However, in hepatocellular carcinoma and clear-cell renal cell carcinoma, FOXJ1 is overexpressed and the expression levels correlate with poor prognosis[1].
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FOXJ1 Related Products (1)
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FOXJ1 agonist 1
0 ImagesCat. No.: HY-163982FOXJ1 agonist 1 (compound 16c) is an orally effective small molecule that can effectively enhance the expression of FOXJ1. Foxj1-IN-1 acts on the mammalian airway system composed of multiciliated cells (MCC) to prevent the development and onset of chronic obstructive pulmonary disease (COPD). Foxj1-IN-1 can induce the production of motile cilia in the respiratory system of zebrafish and mammals, and inhibit elastase-induced COPD mouse models. Foxj1-IN-1 has good liver microsomal stability, in vivo PK curve and AUC; it has no significant inhibition of CYP and hERG, and does not have significant cytotoxicity.
