Cat. No.: HY-12815

MCC950

(Synonyms: CP-456773; CRID3)

456 Cited Publications

Customer Review

Based on 456 publication(s) in Google Scholar

MCC950 (CP-456773; CRID3) is a potent and selective NLRP3 inhibitor with IC₅₀s of 7.5 and 8.1 nM in BMDMs and HMDMs, respectively.

For research use only. We do not sell to patients.

Purity: 99.78%
CAS No.: 210826-40-7
Formula: C₂₀H₂₄N₂O₅S
Molecular Weight:404.48

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

MCC950 Chemical Structure

CAS No.: 210826-40-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (456)
Solvent & Solubility
- In Vitro
- In Vivo
Protocol
Purity & Documentation
References
Help & FAQs
Bioz

Biological Activity

Description

MCC950 (CP-456773; CRID3) is a potent and selective NLRP3 inhibitor with IC₅₀s of 7.5 and 8.1 nM in BMDMs and HMDMs, respectively.

IC₅₀ & Target

NLRP3

All NOD-like Receptor (NLR) Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	CC₅₀	>62.5 μM Compound: MCC950	Cytotoxicity against human HEK293 cells assessed as decrease in cell viability after 20 hrs by resazurin based fluorescence assay Cytotoxicity against human HEK293 cells assessed as decrease in cell viability after 20 hrs by resazurin based fluorescence assay	[PMID: 27994733]
HepG2	CC₅₀	>62.5 μM Compound: MCC950	Cytotoxicity against human HepG2 cells assessed as decrease in cell viability after 20 hrs by resazurin based fluorescence assay Cytotoxicity against human HepG2 cells assessed as decrease in cell viability after 20 hrs by resazurin based fluorescence assay	[PMID: 27994733]
PBMC	IC₅₀	>40 μM Compound: CP-456,773; MCC950, CRID3	Inhibition of LPS-induced IL-6 secretion in human PBMC cells incubated for 4 hrs by ELISA Inhibition of LPS-induced IL-6 secretion in human PBMC cells incubated for 4 hrs by ELISA	[PMID: 37874905]
PBMC	IC₅₀	>40 μM Compound: CP-456,773; MCC950, CRID3	Inhibition of LPS-induced TNFalpha secretion in human PBMC cells incubated for 4 hrs by ELISA Inhibition of LPS-induced TNFalpha secretion in human PBMC cells incubated for 4 hrs by ELISA	[PMID: 37874905]
THP-1	CC₅₀	81.35 μM Compound: 1; MCC950	Cytotoxicity against human THP-1 assessed as reduction in cell viability measured after 72 hrs by CCK-8 assay Cytotoxicity against human THP-1 assessed as reduction in cell viability measured after 72 hrs by CCK-8 assay	[PMID: 35436667]
THP-1	IC₅₀	>100 μM Compound: MCC950	Cytotoxicity against human THP-1 cells assessed as cellular proliferation inhibition measured after 48 hrs by MTT assay Cytotoxicity against human THP-1 cells assessed as cellular proliferation inhibition measured after 48 hrs by MTT assay	[PMID: 38888047]
THP-1	IC₅₀	0.008 μM Compound: MCC 950	Inhibition of IL-1beta release in PMA-differentiated/ LPS and nigericin stimulated human THP-1 cells pretreated with LPS for 3 hrs followed by incubation with compound for 40 mins and later stimulated with nigericin for 40 mins by ELISA Inhibition of IL-1beta release in PMA-differentiated/ LPS and nigericin stimulated human THP-1 cells pretreated with LPS for 3 hrs followed by incubation with compound for 40 mins and later stimulated with nigericin for 40 mins by ELISA	[PMID: 39169676]
THP-1	IC₅₀	8 nM Compound: 1; MCC950, CRID3, CP-456,773	Inhibition of NLRP3 inflammasome activation in LPS-primed human THP1 cells assessed as reduction in IL-1beta level preincubated for 1 hr followed by addition of ATP and nigericin further incubated for 1 hrs and measured post ATP addition 1 hr by ELISA met Inhibition of NLRP3 inflammasome activation in LPS-primed human THP1 cells assessed as reduction in IL-1beta level preincubated for 1 hr followed by addition of ATP and nigericin further incubated for 1 hrs and measured post ATP addition 1 hr by ELISA met	[PMID: 32292543]
THP-1	IC₅₀	98.83 μM Compound: 29; MCC950	Cytotoxicity in human THP-1 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity in human THP-1 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 33332136]

In Vitro

MCC950 blocks canonical and non-canonical NLRP3 activation at nanomolar concentrations. MCC950 specifically inhibits NLRP3 but not AIM2, NLRC4 or NLRP1 activation. The effect of MCC950 on NLRP3 inflammasome activation is tested in mouse bone marrow derived macrophages (BMDM) and human monocyte derived macrophages (HMDM). The IC₅₀ of MCC950 in BMDM is approximately 7.5 nM, while in HMDM it has a similar inhibitory capacity (IC₅₀=8.1 nM). MCC950 also dose dependently inhibit IL-1β but not TNF-α secretion.MCC950 specifically blocks caspase-11-directed NLRP3 activation and IL-1β secretion upon stimulation of the non-canonical pathway. NLRC4-stimulated IL-1β and TNF-α secretion (as activated by Salmonella typhimurium) are not inhibited by MCC950 even at a concentration of 10 μM. MCC950 does not inhibit caspase-1 activation or IL-1β processing in response to S. typhimurium. The expression of pro-caspase-1 and pro-IL-1β in cell lysates is not substantially affected by MCC950 treatment^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

MCC950 reduces Interleukin-1p (IL-1β) production and attenuates the severity of experimental autoimmune encephalomyelitis (EAE), a disease model of multiple sclerosis. Pre-treatment with MCC950 reduces serum concentrations of IL-1β and IL-6 while it does not considerably decrease the amount of TNF-α. Treatment of mice with MCC950 delays the onset and reduced the severity of EAE. Intracellular cytokine staining and FACS analysis of brain mononuclear cells from mice sacrificed on day 22 shows modestly reduced frequencies of IL-17 and IFN-γ producing CD3⁺ T cells in MCC950 treated mice in comparison with PBS-treated mice. IFN-γ and particularly IL-17 producing cell numbers are also reduced in both the CD4⁺ and γδ⁺ sub-populations of CD3⁺ T cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 210826-40-7
Appearance Solid
Molecular Weight 404.48
Formula C₂₀H₂₄N₂O₅S
Color White to light yellow
SMILES

O=S(C1=CC(C(C)(O)C)=CO1)(NC(NC2=C3CCCC3=CC4=C2CCC4)=O)=O
Synonyms

CP-456773; CRID3
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (456)

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Signal Transduct Target Ther

Pulsed electromagnetic fields inhibit atherosclerosis by regulating pyroptosis through membrane tension-mediated mechanosensitive channels. [Abstract]

2025 Nov 28;10(1):388. PMID: 41309549
Signal Transduct Target Ther

A20 attenuates oxidized self-DNA-mediated inflammation in acute kidney injury. [Abstract]

2025 Apr 25;10(1):154. PMID: 40280946
Nature

Recognition and maturation of IL-18 by caspase-4 noncanonical inflammasome. [Abstract]

2023 Dec;624(7991):442-450. PMID: 37993714
Science

Enteroviral 3C protease activates the human NLRP1 inflammasome in airway epithelia. [Abstract]

2020 Dec 4;370(6521):eaay2002. PMID: 33093214
Nat Immunol

Distinct changes in endosomal composition promote NLRP3 inflammasome activation. [Abstract]

2023 Jan;24(1):30-41. PMID: 36443515
Immunity

Disruption of the Na+/K+-ATPase-purinergic P2X7 receptor complex in microglia promotes stress-induced anxiety. [Abstract]

2024 Mar 12;57(3):495-512.e11. PMID: 38395698
Bioact Mater

Lysosomal destabilization: A missing link between pathological calcification and osteoarthritis. [Abstract]

2023 Dec 14:34:37-50. PMID: 38173842
Cell Mol Immunol

The role of the IL-9‒NLRP3 axis in insulin resistance and adipose tissue inflammation during diet-induced obesity. [Abstract]

2025 Sep 18. PMID: 40962954
Cell Mol Immunol

NLRP3-dependent pyroptosis is required for HIV-1 gp120-induced neuropathology. [Abstract]

2020 Mar;17(3):283-299. PMID: 31320730
Sci Immunol

Epithelial Gasdermin D shapes the host-microbial interface by driving mucus layer formation. [Abstract]

2022 Feb 4;7(68):eabk2092. PMID: 35119941
ACS Nano

Molybdenum Nanodots for Acute Lung Injury Therapy. [Abstract]

2023 Dec 12;17(23):23872-23888. PMID: 38084420
Nat Commun

Human iPSC-based Modeling of Pulmonary Fibrosis Reveals p300/CBP Inhibition Suppresses Alveolar Transitional Cell State. [Abstract]

2026 Feb 12;17(1):1214. PMID: 41680175
Nat Commun

Mast cells boost anti-tumor potency of MAIT cells via inflammasome-dependent secretion of IL-18. [Abstract]

2025 Jul 2;16(1):6074. PMID: 40603850
Nat Commun

Oxidized mitochondrial DNA induces gasdermin D oligomerization in systemic lupus erythematosus. [Abstract]

2023 Feb 16;14(1):872. PMID: 36797275
Nat Commun

Polyamine metabolism impacts T cell dysfunction in the oral mucosa of people living with HIV. [Abstract]

2023 Jan 25;14(1):399. PMID: 36693889
Cell Death Differ

FAAH served a key membrane-anchoring and stabilizing role for NLRP3 protein independently of the endocannabinoid system. [Abstract]

2023 Jan;30(1):168-183. PMID: 36104448
Sci Transl Med

Targeting Src reactivates pyroptosis to reverse chemoresistance in lung and pancreatic cancer models. [Abstract]

2023 Jan 11;15(678):eabl7895. PMID: 36630483
Autophagy

Inhibiting NLRP3 inflammasome attenuates apoptosis in contrast-induced acute kidney injury through the upregulation of HIF1A and BNIP3-mediated mitophagy. [Abstract]

2021 Oct;17(10):2975-2990. PMID: 33345685
Adv Sci (Weinh)

Generation of Anti-Mastitis Gene-Edited Dairy Goats with Enhancing Lysozyme Expression by Inflammatory Regulatory Sequence using ISDra2-TnpB System. [Abstract]

2024 Aug 5:e2404408. PMID: 39099401
Adv Sci (Weinh)

A Bioinspired Immunostimulatory System for Inducing Powerful Antitumor Immune Function by Directly Causing Plasma Membrane Rupture. [Abstract]

2024 May;11(20):e2305934. PMID: 38484186
J Adv Res

Live and pasteurized Akkermansia muciniphila decrease susceptibility to Salmonella Typhimurium infection in mice. [Abstract]

2023 Oct:52:89-102. PMID: 36996967
Small

Alpha-Emitter Radium-223 Induces STING-Dependent Pyroptosis to Trigger Robust Antitumor Immunity. [Abstract]

2024 Mar;20(9):e2307448. PMID: 37845027
Redox Biol

Inhibition of NLRP3-mediated crosstalk between hepatocytes and liver macrophages by geniposidic acid alleviates cholestatic liver inflammatory injury. [Abstract]

2022 Sep:55:102404. PMID: 35868156
Redox Biol

NLRP3 inflammasome-mediated pyroptosis contributes to the pathogenesis of non-ischemic dilated cardiomyopathy. [Abstract]

2020 Jul;34:101523. PMID: 32273259
Redox Biol

PINK1-parkin pathway of mitophagy protects against contrast-induced acute kidney injury via decreasing mitochondrial ROS and NLRP3 inflammasome activation. [Abstract]

2019 Sep:26:101254. PMID: 31229841
Engineering

2025 Aug 14.
Engineering

2024 May 22.
J Control Release

Platelet-derived extracellular vesicles to target plaque inflammation for effective anti-atherosclerotic therapy. [Abstract]

2021 Jan 10;329:445-453. PMID: 33285103
J Hazard Mater

NLRP3 inflammasome mediates pyroptosis of alveolar macrophages to induce radiation lung injury. [Abstract]

2024 Dec 1:484:136740. PMID: 39642726
Small Struct

2024 Feb 5.
J Hazard Mater

Arsenic induces hepatic insulin resistance via mtROS-NLRP3 inflammasome pathway. [Abstract]

2020 Nov 15;399:123034. PMID: 32544768
J Allergy Clin Immunol

IL-17A mediates pyroptosis via the ERK pathway and contributes to steroid resistance in CRSwNP. [Abstract]

2022 Aug;150(2):337-351. PMID: 35346673
Gut Microbes

Antibiotic cocktail-induced changes in gut microbiota drive alteration of bile acid metabolism to restrain Th17 differentiation through the FXR-NLRP3 axis. [Abstract]

2025 Dec 31;17(1):2582944. PMID: 41305918
Research (Wash D C)

2025 Dec 22.
Research (Wash D C)

Interleukin-4-Mediated NLRP3 Inflammasome Activation in Microglia Contributes to Allergic Rhinitis via Central Sensitization. [Abstract]

2025 Sep 25:2025:0897. PMID: 41019284
Pharmacol Res

NLRP3 inflammasome links vascular senescence to diabetic vascular lesions. [Abstract]

2022 Apr:178:106143. PMID: 35219871
Pharmacol Res

Cryptotanshinone specifically suppresses NLRP3 inflammasome activation and protects against inflammasome-mediated diseases. [Abstract]

2021 Feb:164:105384. PMID: 33352229
Mater Today Bio

Targeted inflammatory microenvironment remodeling and NIR-II photothermal therapy for abdominal aortic aneurysm. [Abstract]

2026 Jan 6:36:102770. PMID: 41567736
Mol Biomed

ML345 is a potent and selective NLRP3 inflammasome inhibitor with anti-inflammatory activity. [Abstract]

2025 Nov 13;6(1):108. PMID: 41231359
Mol Biomed

Deleting fibroblast growth factor 2 in macrophages aggravates septic acute lung injury by increasing M1 polarization and inflammatory cytokine secretion. [Abstract]

2024 Oct 22;5(1):50. PMID: 39436561
J Neuroinflammation

Herpes simplex virus 1 accelerates the progression of Alzheimer's disease by modulating microglial phagocytosis and activating NLRP3 pathway. [Abstract]

2024 Jul 18;21(1):176. PMID: 39026249
J Neuroinflammation

The circadian clock protein Rev-erbα provides neuroprotection and attenuates neuroinflammation against Parkinson's disease via the microglial NLRP3 inflammasome. [Abstract]

2022 Jun 6;19(1):133. PMID: 35668454
J Neuroinflammation

NLRP3 inflammasome-mediated choroid plexus hypersecretion contributes to hydrocephalus after intraventricular hemorrhage via phosphorylated NKCC1 channels. [Abstract]

2022 Jun 21;19(1):163. PMID: 35729645
J Neuroinflammation

Blockade of the NLRP3/caspase-1 axis attenuates ketamine-induced hippocampus pyroptosis and cognitive impairment in neonatal rats. [Abstract]

2021 Oct 19;18(1):239. PMID: 34666787
J Neuroinflammation

Divanillyl sulfone suppresses NLRP3 inflammasome activation via inducing mitophagy to ameliorate chronic neuropathic pain in mice. [Abstract]

2021 Jun 24;18(1):142. PMID: 34162415
Cancer Lett

NLRP3 inflammasome upregulates PD-L1 expression and contributes to immune suppression in lymphoma. [Abstract]

2021 Jan 28;497:178-189. PMID: 33091534
J Neuroinflammation

NLRP3 inflammasome-mediated microglial pyroptosis is critically involved in the development of post-cardiac arrest brain injury. [Abstract]

2020 Jul 23;17(1):219. PMID: 32703306
J Neuroinflammation

Central blockade of NLRP3 reduces blood pressure via regulating inflammation microenvironment and neurohormonal excitation in salt-induced prehypertensive rats. [Abstract]

2018 Mar 24;15(1):95. PMID: 29573749

MCC950 purchased from MedChemExpress. Usage Cited in: J Neuroinflammation. 2018 Mar 24;15(1):95. [Abstract]

Chronic PVN infusion of MCC950 significantly decreases apoptosis-associated speck-like protein (ASC), pro-caspase-1, and IL-1β expression in high-salt diet rats.
Int J Biol Sci

ANXA6 Overexpression Causes Abnormal Decidual Macrophage-Trophoblast Crosstalk in Recurrent Spontaneous Abortion. [Abstract]

2025 Aug 11;21(12):5206-5222. PMID: 40959268
Int J Biol Sci

Mitochondrial Dysfunction by FADDosome Promotes Gastric Mucosal Injury in Portal Hypertensive Gastropathy. [Abstract]

2024 Apr 29;20(7):2658-2685. PMID: 38725851
Int J Biol Sci

NLRP3 Regulates Mandibular Healing through Interaction with UCHL5 in MSCs. [Abstract]

2023 Jan 16;19(3):936-949. PMID: 36778113
Int J Biol Sci

The advanced glycation end-products (AGEs)/ROS/NLRP3 inflammasome axis contributes to delayed diabetic corneal wound healing and nerve regeneration. [Abstract]

2022 Jan 1;18(2):809-825. PMID: 35002527
Burns Trauma

2026 Jan 6.
Adv Healthc Mater

Dysregulation of Cell Adhesion in Epidermal Stem Cells of Prurigo Nodularis Reduces Their Proliferative Capacity. [Abstract]

2025 Dec 17:e04017. PMID: 41409010
Cell Death Dis

Hepatocyte-specific NR5A2 deficiency induces pyroptosis and exacerbates non-alcoholic steatohepatitis by downregulating ALDH1B1 expression. [Abstract]

2024 Oct 23;15(10):770. PMID: 39438459
Cell Death Dis

Gasdermin D independent canonical inflammasome responses cooperate with caspase-8 to establish host defense against gastrointestinal Citrobacter rodentium infection. [Abstract]

2023 Apr 21;14(4):282. PMID: 37080966
Cell Death Dis

HIF1α-BNIP3-mediated mitophagy protects against renal fibrosis by decreasing ROS and inhibiting activation of the NLRP3 inflammasome. [Abstract]

2023 Mar 17;14(3):200. PMID: 36928344
Cell Death Dis

Honokiol suppresses the aberrant interactions between renal resident macrophages and tubular epithelial cells in lupus nephritis through the NLRP3/IL-33/ST2 axis. [Abstract]

2023 Mar 1;14(3):174. PMID: 36859530
Cell Death Dis

Irisin protects against vascular calcification by activating autophagy and inhibiting NLRP3-mediated vascular smooth muscle cell pyroptosis in chronic kidney disease. [Abstract]

2022 Mar 30;13(3):283. PMID: 35354793
Cell Death Dis

Dehydroepiandrosterone exacerbates nigericin-induced abnormal autophagy and pyroptosis via GPER activation in LPS-primed macrophages. [Abstract]

2022 Apr 19;13(4):372. PMID: 35440074
Cell Death Dis

Complement induces podocyte pyroptosis in membranous nephropathy by mediating mitochondrial dysfunction. [Abstract]

2022 Mar 29;13(3):281. PMID: 35351877
Cell Death Dis

Rosuvastatin protects against coronary microembolization-induced cardiac injury via inhibiting NLRP3 inflammasome activation. [Abstract]

2021 Jan 12;12(1):78. PMID: 33436548
Cell Death Dis

Inhibition of the NLRP3-inflammasome prevents cognitive deficits in experimental autoimmune encephalomyelitis mice via the alteration of astrocyte phenotype. [Abstract]

2020 May 15;11(5):377. PMID: 32415059
Cell Death Dis

Taurine attenuates arsenic-induced pyroptosis and nonalcoholic steatohepatitis by inhibiting the autophagic-inflammasomal pathway. [Abstract]

2018 Sep 20;9(10):946. PMID: 30237538

MCC950 purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2018 Sep 20;9(10):946. [Abstract]

The efficiency of MCC950, and its effect on caspase-1 activation and IL-1β production in As2O3-treated HepG2 cells.
Cell Death Dis

Ly6G+ neutrophil-derived miR-223 inhibits the NLRP3 inflammasome in mitochondrial DAMP-induced acute lung injury. [Abstract]

2017 Nov 16;8(11):e3170. PMID: 29144508
Proc Natl Acad Sci U S A

Ace2 safeguards embryonic hematopoietic stem and progenitor cell production by restraining Nlrp3-mediated pyroptosis. [Abstract]

2025 Dec 9;122(49):e2515641122. PMID: 41348733
Proc Natl Acad Sci U S A

Oxysterol binding protein regulates the resolution of TLR-induced cytokine production in macrophages. [Abstract]

2024 Aug 13;121(33):e2406492121. PMID: 39361877
Nano Res

2026;19(1):94907900.
Osteoarthritis Cartilage

DDIT3 aggravates TMJOA cartilage degradation via Nrf2/HO-1/NLRP3-mediated autophagy. [Abstract]

2024 May 6:S1063-4584(24)01175-0. PMID: 38719085
Cell Commun Signal

NLRP3-mediated epithelial pyroptosis involved in airway hyperresponsiveness in combined eosinophilic and neutrophilic asthma. [Abstract]

2026 Jan 31;24(1):144. PMID: 41620621
Cell Commun Signal

Tricyclic antidepressants induce liver inflammation by targeting NLRP3 inflammasome activation. [Abstract]

2023 May 25;21(1):123. PMID: 37231437
Int J Biol Macromol

Glutathion peroxidase 4 (GPX4) and Ribosomal Protein L40 (RPL40) participate in arsenic induced progression of renal cell carcinoma by regulating the NLRP3 mediated classic pyroptosis pathway. [Abstract]

2025 Apr 14:143129. PMID: 40239794
Int J Biol Macromol

Serine protease Rv2569c inhibits inflammatory response and promotes intracellular survival of Mycobacterium tuberculosis by targeting the RhoG-NF-κB-NLRP3 pathway. [Abstract]

2025 Apr 12:143022. PMID: 40228763
Acta Pharmacol Sin

Microglial STING activation promotes neuroinflammation and pathological changes in experimental mice with intracerebral haemorrhage. [Abstract]

2025 Apr 8. PMID: 40200123
Acta Pharmacol Sin

ML365 inhibits TWIK2 channel to block ATP-induced NLRP3 inflammasome. [Abstract]

2022 Apr;43(4):992-1000. PMID: 34341510
Acta Pharmacol Sin

Lp-PLA2 inhibition prevents Ang II-induced cardiac inflammation and fibrosis by blocking macrophage NLRP3 inflammasome activation. [Abstract]

2021 Dec;42(12):2016-2032. PMID: 34226664
Phytomedicine

GSTM2 as the molecular linking of depression-driven colon cancer progression and chemoresistance: Reversal by Sinisan. [Abstract]

2026 Jun:155:158113. PMID: 41962265
Phytomedicine

Pterostilbene mitigates scopolamine-induced cognitive impairment by modulating cholinergic pathway and reducing neuroinflammation. [Abstract]

2025 Dec 1:150:157630. PMID: 41353883
EMBO J

Cardiolipin inhibits the non-canonical inflammasome by preventing LPS binding to caspase-4/11. [Abstract]

2025 Aug;44(16):4419-4442. PMID: 40670771
Phytomedicine

Maiwei Yangfei decoction protects against pulmonary fibrosis by suppressing NLRP3 inflammasome-mediated pyroptosis of alveolar macrophage. [Abstract]

2025 Sep:145:157041. PMID: 40652799
Phytomedicine

Salvianolic acid B alleviated myocardial ischemia-reperfusion injury via modulating SIRT3-mediated crosstalk between mitochondrial ROS and NLRP3. [Abstract]

2024 Nov 14:136:156260. PMID: 39579610
Phytomedicine

Tryptanthrin suppresses multiple inflammasome activation to regulate NASH progression by targeting ASC protein. [Abstract]

2024 May 28:131:155758. PMID: 38843643
Phytomedicine

Lupeol alleviates autoimmune myocarditis by suppressing macrophage pyroptosis and polarization via PPARα/LACC1/NF-κB signaling pathway. [Abstract]

2024 Jan:123:155193. PMID: 37976692
Phytomedicine

Helenine blocks NLRP3 activation by disrupting the NEK7-NLRP3 interaction and ameliorates inflammatory diseases. [Abstract]

2024 Jan:122:155159. PMID: 37931457
Phytomedicine

Sophflarine A, a novel matrine-derived alkaloid from Sophora flavescens with therapeutic potential for non-small cell lung cancer through ROS-mediated pyroptosis and autophagy. [Abstract]

2023 Jul 25:116:154909. PMID: 37269775
EMBO J

Prohibitin 1 regulates mtDNA release and downstream inflammatory responses. [Abstract]

2022 Oct 17;e111173. PMID: 36245295

MCC950 purchased from MedChemExpress. Usage Cited in: EMBO J. 2022 Oct 17;e111173. [Abstract]

BMDMs isolated from Phb1F/F mice and Phb1MyeKO mice are incubated with MCC950 (50 nM) for 30 min and are subsequently stimulated by LPS (200 ng/ml) for 6 h and ATP (4 mM) for 45 min. Protein levels in whole cell lysates and culture medium are detected by WB assay.
Free Radic Biol Med

Forchlorfenuron exposure induces cardiotoxicity via NF-κB/NLRP3-mediated inflammasome activation independent of Septin2 inhibition. [Abstract]

2025 Dec 16:244:348-366. PMID: 41412525
Free Radic Biol Med

Lipotoxicity-induced upregulation of FIS1 exacerbates mitochondrial fragmentation and promotes NLRP3-dependent pyroptosis in diabetic cardiomyopathy. [Abstract]

2025 Feb 16:228:183-196. PMID: 39734056
Free Radic Biol Med

Inhibition of the NLRP3/caspase-1 cascade related pyroptosis relieved propofol-induced neuroinflammation and cognitive impairment in developing rats. [Abstract]

2024 Nov 20:225:87-97. PMID: 39341300
Free Radic Biol Med

Mitochondrial GRIM-19 loss in parietal cells promotes spasmolytic polypeptide-expressing metaplasia through NLR family pyrin domain-containing 3 (NLRP3)-mediated IL-33 activation via a reactive oxygen species (ROS) -NRF2- Heme oxygenase-1(HO-1)-NF-кB axis. [Abstract]

2023 Mar 27;202:46-61. PMID: 36990300
Free Radic Biol Med

Wedelolactone alleviates acute pancreatitis and associated lung injury via GPX4 mediated suppression of pyroptosis and ferroptosis. [Abstract]

2021 Sep:173:29-40. PMID: 34246777
Apoptosis

AIM2-PANoptosome-driven PANoptosis in hepatic lipid dysregulation induced by β-HCH and nanoplastics co-exposure. [Abstract]

2025 Jul 23. PMID: 40702248
Apoptosis

The gut microbial metabolite phenylacetylglutamine increases susceptibility to atrial fibrillation after myocardial infarction through ferroptosis and NLRP3 inflammasome. [Abstract]

2024 Dec 3. PMID: 39627575
Chemosphere

Autophagic-CTSB-inflammasome axis modulates hepatic stellate cells activation in arsenic-induced liver fibrosis. [Abstract]

2020 Mar;242:124959. PMID: 31669990
Sci Total Environ

NLRP3 inflammasome activation triggers severe inflammatory liver injury in N, N-dimethylformamide-exposed mice. [Abstract]

2024 Jun 15:929:172653. PMID: 38649053
Sci Total Environ

Activation of NLRP3 signaling contributes to cadmium-induced bone defects, associated with autophagic flux obstruction. [Abstract]

2023 Oct 1:893:164787. PMID: 37321488
Sci Total Environ

Combined exposure to benzo(a)pyrene and dibutyl phthalate aggravates pro-inflammatory macrophage polarization in spleen via pyroptosis involving cathepsin B. [Abstract]

2023 Jul 10:881:163460. PMID: 37061049
Basic Res Cardiol

Mitochondrial calpain-1 activates NLRP3 inflammasome by cleaving ATP5A1 and inducing mitochondrial ROS in CVB3-induced myocarditis. [Abstract]

2022 Aug 23;117(1):40. PMID: 35997820
J Orthop Translat

2026 Jan 6.
J Orthop Translat

SHP2-mediated ROS activation induces chondrocyte paraptosis in osteoarthritis and is attenuated by low-intensity pulsed ultrasound. [Abstract]

2025 Apr 25:52:233-248. PMID: 40337549
Br J Pharmacol

Cerebroprotection by dioscin after experimental subarachnoid haemorrhage via inhibiting NLRP3 inflammasome through SIRT1-dependent pathway. [Abstract]

2021 Sep;178(18):3648-3666. PMID: 33904167
Brain Behav Immun

Remifentanil-induced inflammation in microglial cells: Activation of the PAK4-mediated NF-κB/NLRP3 pathway and onset of hyperalgesia. [Abstract]

2024 Sep 23:S0889-1591(24)00621-4. PMID: 39322089
J Transl Med

L-Fucose alleviates inflammation, pyroptosis and mitochondrial injury in obesity-related cardiac injury via TLR4/MyD88/NF-κB pathway. [Abstract]

2025 Dec 8;23(1):1385. PMID: 41361467
J Transl Med

Polystyrene nanoplastics trigger pyroptosis in dopaminergic neurons through TSC2/TFEB-mediated disruption of autophagosome-lysosome fusion in Parkinson's disease. [Abstract]

2025 Jun 5;23(1):631. PMID: 40474178
Biomed Pharmacother

Ginkgolide B effectively mitigates neuropathic pain by suppressing the activation of the NLRP3 inflammasome through the induction of mitophagy in rats. [Abstract]

2024 Jun 21:177:117006. PMID: 38908197
J Transl Med

Fucoidan modulates SIRT1 and NLRP3 to alleviate hypertensive retinopathy: in vivo and in vitro insights. [Abstract]

2024 Feb 15;22(1):155. PMID: 38360728
J Transl Med

C3a/C3aR synergies with TGF-β to promote epithelial-mesenchymal transition of renal tubular epithelial cells via the activation of the NLRP3 inflammasome. [Abstract]

2023 Dec 11;21(1):904. PMID: 38082306
Biomed Pharmacother

Daphnetin ameliorates PM2.5-induced airway inflammation by inhibiting NLRP3 inflammasome-mediated pyroptosis in CS-exposed mice. [Abstract]

2023 Sep:165:115047. PMID: 37390709
Biomed Pharmacother

Mechanical stress protects against chondrocyte pyroptosis through TGF-β1-mediated activation of Smad2/3 and inhibition of the NF-κB signaling pathway in an osteoarthritis model. [Abstract]

2023 Mar:159:114216. PMID: 36634591
Biomed Pharmacother

Inhibition of the NLRP3/caspase-1 signaling cascades ameliorates ketamine-induced renal injury and pyroptosis in neonatal rats. [Abstract]

2022 Aug:152:113229. PMID: 35679721
Emerg Microbes Infect

Propionibacterium acnes induces intervertebral disc degeneration by promoting nucleus pulposus cell apoptosis via the TLR2/JNK/mitochondrial-mediated pathway. [Abstract]

2018 Jan 10;7(1):1. PMID: 29323102
Food Sci Hum Wellness

2025.
Oncogene

Targeting TFAM downregulation mediated mtDNA-NLRP3 pathway suppresses TAM infiltration and HCC progression. [Abstract]

2025 Sep;44(33):2956-2969. PMID: 40517169
Aging Cell

Aerobic Exercise Restores Hippocampal Neurogenesis and Cognitive Function by Decreasing Microglia Inflammasome Formation Through Irisin/NLRP3 Pathway. [Abstract]

2025 Apr 7:e70061. PMID: 40192010
Aging Cell

Age-dependent loss of hepatic SIRT1 enhances NLRP3 inflammasome signaling and impairs capacity for liver fibrosis resolution. [Abstract]

2023 May;22(5):e13811. PMID: 36999514
Neuropsychopharmacology

Enduring glucocorticoid-evoked exacerbation of synaptic plasticity disruption in male rats modelling early Alzheimer's disease amyloidosis. [Abstract]

2021 Nov;46(12):2170-2179. PMID: 34188184
Cell Death Discov

IP3R2-mediated Ca2+ release promotes LPS-induced cardiomyocyte pyroptosis via the activation of NLRP3/Caspase-1/GSDMD pathway. [Abstract]

2024 Feb 20;10(1):91. PMID: 38378646
Cell Death Discov

Coal dust nanoparticles induced pulmonary fibrosis by promoting inflammation and epithelial-mesenchymal transition via the NF-κB/NLRP3 pathway driven by IGF1/ROS-mediated AKT/GSK3β signals. [Abstract]

2022 Dec 29;8(1):500. PMID: 36581638
Cell Rep

The Hippo pathway kinase MST1 mediates a feedback loop to maintain NLRP3 inflammasome homeostasis. [Abstract]

2025 Jul 26;44(8):116076. PMID: 40716062
Cell Rep

ENPP1 governs the metabolic regulation of effector T cells in autoimmunity by detecting cytosolic mitochondrial DNA. [Abstract]

2025 Jun 13;44(6):115851. PMID: 40516055
Cell Rep

Myeloid-lineage-specific membrane protein LRRC25 suppresses immunity in solid tumor and is a potential cancer immunotherapy checkpoint target. [Abstract]

2025 Apr 24;44(5):115631. PMID: 40279244
Cell Rep

Ornithine lipid is a partial TLR4 agonist and NLRP3 activator. [Abstract]

2024 Sep 26;43(10):114788. PMID: 39340778
Cell Rep

Negative regulation of TREM2-mediated C9orf72 poly-GA clearance by the NLRP3 inflammasome. [Abstract]

2023 Feb 16;42(2):112133. PMID: 36800288
Clin Transl Med

ATG16L1 restrains macrophage NLRP3 activation and alveolar epithelial cell injury during septic lung injury. [Abstract]

2025 Apr;15(4):e70289. PMID: 40211890
J Med Chem

Deep-Learning-Driven Discovery of SN3-1, a Potent NLRP3 Inhibitor with Therapeutic Potential for Inflammatory Diseases. [Abstract]

2024 Oct 10;67(19):17833-17854. PMID: 39302813
Clin Transl Med

Mitochondrial dysfunction induced by HIF-1α under hypoxia contributes to the development of gastric mucosal lesions. [Abstract]

2024 Apr;14(4):e1653. PMID: 38616702
Clin Transl Med

Translocation of gasdermin D induced mitochondrial injury and mitophagy mediated quality control in lipopolysaccharide related cardiomyocyte injury. [Abstract]

2022 Aug;12(8):e1002. PMID: 36030524
Neural Regen Res

MCC950 suppresses NLRP3-dependent neuroinflammation and ameliorates cognitive decline in a rat model of cerebral small vessel disease. [Abstract]

2025 Jun 19. PMID: 40537012
Neural Regen Res

Inhibition of the NLRP3 inflammasome attenuates spiral ganglion neuron degeneration in aminoglycoside-induced hearing loss. [Abstract]

2025 Oct 1;20(10):3025-3039. PMID: 39610108
Antioxidants (Basel)

Ginsenoside Rg1 Alleviates Blood-Milk Barrier Disruption in Subclinical Bovine Mastitis by Regulating Oxidative Stress-Induced Excessive Autophagy. [Abstract]

2024 Nov 24;13(12):1446. PMID: 39765775
Antioxidants (Basel)

Bone Marrow Mesenchymal Stem Cell-Derived Exosomes Ameliorate Aging-Induced BTB Impairment in Porcine Testes by Activating Autophagy and Inhibiting ROS/NLRP3 Inflammasomes via the AMPK/mTOR Signaling Pathway. [Abstract]

2024 Jan 31;13(2):183. PMID: 38397781
Int J Nanomedicine

Apelin-13-Loaded Macrophage Membrane-Encapsulated Nanoparticles for Targeted Ischemic Stroke Therapy via Inhibiting NLRP3 Inflammasome-Mediated Pyroptosis. [Abstract]

2024 Sep 7:19:9175-9193. PMID: 39263632
Mol Med

ACT001 improves OVX-induced osteoporosis by suppressing the NF-κB/NLRP3 signaling pathway. [Abstract]

2025 Apr 7;31(1):131. PMID: 40197211
Phytother Res

Berberine Ameliorates Atrial Remodeling and Inhibits the Atrial Fibrillation of Mice via Regulating NLRP3 Inflammasome. [Abstract]

2025 Jul 26. PMID: 40716066
Phytother Res

Emodin Promotes Peripheral Nerve Repair by Modulating Inflammasome Activation Through Autophagy via the EGFR/PI3K/AKT/mTOR Pathway. [Abstract]

2025 Mar 26. PMID: 40135386
Phytother Res

Dihydrocapsaicin suppresses the STING-mediated accumulation of ROS and NLRP3 inflammasome and alleviates apoptosis after ischemia-reperfusion injury of perforator skin flap. [Abstract]

2024 May;38(5):2539-2559. PMID: 38459660
J Agric Food Chem

Chronic Arsenic Exposure Induces Neuroinflammation by Regulating the Nrf2/NLRP3 Inflammasome Signaling Pathway. [Abstract]

2025 Dec 17;73(50):31853-31864. PMID: 41353618
J Agric Food Chem

Natural Dietary Flavonoid Apigenin Mitigates Ulcerative Colitis via Modulating the AMPK/NF-κB/NLRP3 Signaling Axis. [Abstract]

2025 Dec 22. PMID: 41428381
J Agric Food Chem

Curcumin Alleviates Bisphenol A-Induced Blood-Testis Barrier Disruption in Mice by Targeting Surfactant Protein B (SFTPB) to Suppress Oxidative Stress-Activated NLRP3 Inflammasome. [Abstract]

2025 Nov 19;73(46):29874-29885. PMID: 41212106
J Agric Food Chem

β-Hydroxybutyric Acid-Induced Bovine Endometrial Epithelial Cell Pyroptosis via Activating P2X7R. [Abstract]

2025 Aug 27;73(34):21296-21308. PMID: 40742321
J Agric Food Chem

Rosmarinic Acid Ameliorates Type 2 Diabetic Osteoporosis by Reducing NLRP3 Expression and Alleviating Osteoblast Pyroptosis via the FOXO1/TXNIP Signaling Pathway. [Abstract]

2025 Jul 2;73(26):16557-16572. PMID: 40552618
J Agric Food Chem

3-MCPD Induces Renal Cell Pyroptosis and Inflammation by Inhibiting ESCRT-III-Mediated Cell Repair and Mitophagy. [Abstract]

2024 Jun 10. PMID: 38857427
J Agric Food Chem

Free Fatty Acids Induce Apoptosis of Mammary Epithelial Cells of Ketotic Dairy Cows via the Mito-ROS/NLRP3 Signaling Pathway. [Abstract]

2023 Aug 30;71(34):12645-12656. PMID: 37585786
J Agric Food Chem

Apigenin Alleviated High-Fat-Diet-Induced Hepatic Pyroptosis by Mitophagy-ROS-CTSB-NLRP3 Pathway in Mice and AML12 Cells. [Abstract]

2023 May 10;71(18):7032-7045. PMID: 37141464

MCC950 purchased from MedChemExpress. Usage Cited in: J Agric Food Chem. 2023 May 10;71(18):7032-7045. [Abstract]

MCC950 (10 μM; 2 h) markedly inhibits the expressionof NLRP3, Cleaved Caspase-1, and Cleaved IL-1β in HUVECs.
J Agric Food Chem

Eugenol Alleviates TGEV-Induced Intestinal Injury via Suppressing ROS/NLRP3/GSDMD-Dependent Pyroptosis. [Abstract]

2023 Jan 25;71(3):1477-1487. PMID: 36642968
EMBO Rep

Licochalcone B specifically inhibits the NLRP3 inflammasome by disrupting NEK7-NLRP3 interaction. [Abstract]

2022 Feb 3;23(2):e53499. PMID: 34882936
J Agric Food Chem

Estrogen Receptor α Regulates Metabolic-Associated Fatty Liver Disease by Targeting NLRP3-GSDMD Axis-Mediated Hepatocyte Pyroptosis. [Abstract]

2021 Dec 8;69(48):14544-14556. PMID: 34817168
J Agric Food Chem

Sodium Sulfite-Induced Mast Cell Pyroptosis and Degranulation. [Abstract]

2021 Jul 14;69(27):7755-7764. PMID: 34191510
Ecotoxicol Environ Saf

Blue light induces corneal epithelial damage by activating the NLRP3 inflammasome pathway. [Abstract]

2025 Aug 23:303:118921. PMID: 40850112
Ecotoxicol Environ Saf

Co-exposure of microcystin-LR and nitrite induced kidney injury through TLR4/NLRP3/GSDMD-mediated pyroptosis. [Abstract]

2024 Jun 24:281:116629. PMID: 38917587
Ecotoxicol Environ Saf

VX-765 attenuates silica-induced lung inflammatory injury and fibrosis by modulating alveolar macrophages pyroptosis in mice. [Abstract]

2023 Jan 1:249:114359. PMID: 36508797
Ecotoxicol Environ Saf

NLRP3 inflammasome blocked the glycolytic pathway via targeting to PKLR in arsenic-induced hepatic insulin resistance. [Abstract]

2021 Oct 15:223:112590. PMID: 34364127
Cell Biol Toxicol

AS3MT facilitates NLRP3 inflammasome activation by m6A modification during arsenic-induced hepatic insulin resistance. [Abstract]

2023 Oct;39(5):2165-2181. PMID: 35226250
J Dent Res

Leptin Aggravates Periodontitis by Promoting M1 Polarization via NLRP3. [Abstract]

2022 Jun;101(6):675-685. PMID: 35050801
Front Immunol

The Increase in IL-1β in the Early Stage of Heatstroke Might Be Caused by Splenic Lymphocyte Pyroptosis Induced by mtROS-Mediated Activation of the NLRP3 Inflammasome. [Abstract]

2020 Jul 24;11:1863. PMID: 31921131
Int J Mol Med

Hypothermic machine perfusion protects DCD graft liver from ischemia‑reperfusion injury by enhancing macrophage efferocytosis via KLF2‑NLRP3 signaling. [Abstract]

2026 Apr;57(4):85. PMID: 41645764
Int J Mol Med

Irisin attenuates acute lung injury by suppressing the pyroptosis of alveolar macrophages. [Abstract]

2023 Apr;51(4):32. PMID: 36896789
Int J Mol Med

Silencing of miR‑155 suppresses inflammatory responses in psoriasis through inflammasome NLRP3 regulation. [Abstract]

2018 Aug;42(2):1086-1095. PMID: 29767259
Acta Neuropathol Commun

Transient receptor potential vanilloid 4 blockage attenuates pyroptosis in hippocampus of mice following pilocarpine‑induced status epilepticus. [Abstract]

2025 Apr 10;13(1):73. PMID: 40205503
J Invest Dermatol

Advanced Glycation End Products Promote Melanogenesis by Activating NLRP3 Inflammasome in Human Dermal Fibroblasts. [Abstract]

2022 Oct;142(10):2591-2602.e8. PMID: 35421403
Atherosclerosis

Inhibition of vascular neointima hyperplasia by FGF21 associated with FGFR1/Syk/NLRP3 inflammasome pathway in diabetic mice. [Abstract]

2019 Oct;289:132-142. PMID: 31513948
Biochem Pharmacol

Agomir-223 treatment after lung blast injury reduces the inflammatory response by regulating the NLRP3 inflammasome to inhibit M1 macrophage function. [Abstract]

2025 Aug 12;242(Pt 1):117220. PMID: 40812582
Biochem Pharmacol

NLRP3 inflammasome activation contributes to the development of the pro-fibrotic phenotype of lung fibroblasts. [Abstract]

2024 Aug 17:116496. PMID: 39159876
Neurobiol Dis

TRPM2 contributes to neuroinflammation and cognitive deficits in a cuprizone-induced multiple sclerosis model via NLRP3 inflammasome. [Abstract]

2021 Dec:160:105534. PMID: 34673151
Cell Prolif

NLRP3 regulates alveolar bone loss in ligature-induced periodontitis by promoting osteoclastic differentiation. [Abstract]

2021 Feb;54(2):e12973. PMID: 33382502
Neurobiol Dis

Selective NLRP3 inflammasome inhibitor reduces neuroinflammation and improves long-term neurological outcomes in a murine model of traumatic brain injury. [Abstract]

2018 Sep:117:15-27. PMID: 29859317

MCC950 purchased from MedChemExpress. Usage Cited in: Neurobiol Dis. 2018 Sep:117:15-27. [Abstract]

Effect of MCC950 on the expression of NLRP3 inflammasome components and substrates after traumatic brain injury (TBI).
Neurobiol Dis

NLRP3-dependent synaptic plasticity deficit in an Alzheimer's disease amyloidosis model in vivo. [Abstract]

2018 Jun;114:24-30. PMID: 29477641
Am J Chin Med

Rhein Alleviates Cerebral Ischemia/Reperfusion Injury by Inhibiting the Microglial NLRP3 Inflammasome/Pyroptosis Axis and Regulating Microglial M1/M2 Phenotypes. [Abstract]

2026;54(1):263-284. PMID: 41684092
J Gastroenterol

Heparan sulfate acts as an activator of the NLRP3 inflammasome promoting inflammatory response in the development of acute pancreatitis. [Abstract]

2024 Sep;59(9):869-879. PMID: 38864913
J Ethnopharmacol

Danggui-Shaoyao-San ameliorates metabolic dysfunction-associated steatohepatitis via suppressing hepatic macrophage NLRP3 inflammasome. [Abstract]

2026 Jul 15:366:121578. PMID: 41905728
Chem Biol Interact

Cytochrome P450-mediated detoxification and NF-κB/NLRP3 pathway-driven hepatotoxicity of emodin: Multiomics and laboratory evidence. [Abstract]

2026 Mar 25:427:111934. PMID: 41579920
J Ethnopharmacol

Guhan Yangsheng Jing alleviates sleep deprivation-induced neuronal injury via neurotransmitter rebalancing, mitochondrial protection, and inhibition of pyroptosis. [Abstract]

2026 Apr 6:360:121209. PMID: 41539636
J Ethnopharmacol

Didymin alleviates neuropathic pain by targeting RKIP-mediated NF-κB/NLRP3 crosstalk to inhibit pyroptosis and neuroinflammation. [Abstract]

2026 Mar 25:359:121046. PMID: 41453551
J Ethnopharmacol

Ginsenoside Rg1 improves chronic neuropathic pain by inhibiting NLRP3 inflammasome activation and cell pyroptosis in microglia. [Abstract]

2025 Jul 30;353(Pt A):120346. PMID: 40750033
Chem Biol Interact

Decabromodiphenyl ether (BDE-209) induces learning and memory impairment via JAK2/STAT3/NLRP3 axis-mediated pyroptosis and neuroinflammation. [Abstract]

2025 Oct 8:419:111665. PMID: 40675405
Food Funct

Sodium butyrate attenuates experimental neonatal necrotizing enterocolitis by suppressing TLR4-mediated NLRP3 inflammasome-dependent pyroptosis. [Abstract]

2025 Apr 14. PMID: 40223745
J Ethnopharmacol

Shuangdan Jiedu Decoction improved LPS-induced acute lung injury by regulating both cGAS-STING pathway and inflammasome. [Abstract]

2024 Aug 17:118661. PMID: 39159837
J Ethnopharmacol

Octahydroindolizine alkaloid Homocrepidine A from Dendrobium crepidatum attenuate P. acnes-induced inflammatory in vitro and in vivo. [Abstract]

2024 Jun 11:118455. PMID: 38871011
J Ethnopharmacol

Xiaoqinglong decoction improves allergic rhinitis by inhibiting NLRP3-mediated pyroptosis in BALB/C mice. [Abstract]

2024 Mar 1:321:117490. PMID: 38030025
J Ethnopharmacol

Shizhifang ameliorates pyroptosis of renal tubular epithelial cells in hyperuricemia through inhibiting NLRP3 inflammasome. [Abstract]

2023 Dec 5:317:116777. PMID: 37311502
Chem Biol Interact

S1P/S1PR2 promote pancreatic stellate cell activation and pancreatic fibrosis in chronic pancreatitis by regulating autophagy and the NLRP3 inflammasome. [Abstract]

2023 Aug 1:380:110541. PMID: 37169277
J Ethnopharmacol

Polydatin protects against atherosclerosis by activating autophagy and inhibiting pyroptosis mediated by the NLRP3 inflammasome. [Abstract]

2023 Jun 12:309:116304. PMID: 36870461
Virulence

A. caviae infection triggers IL-1β secretion through activating NLRP3 inflammasome mediated by NF-κB signaling pathway partly in a TLR2 dependent manner. [Abstract]

2022 Dec;13(1):1486-1501. PMID: 36040120
Inflammopharmacology

Paeoniflorin attenuates chronic constriction injury-induced neuropathic pain by suppressing spinal NLRP3 inflammasome activation. [Abstract]

2020 Dec;28(6):1495-1508. PMID: 32596762
J Am Heart Assoc

Trimethylamine-N-Oxide Induces Vascular Inflammation by Activating the NLRP3 Inflammasome Through the SIRT3-SOD2-mtROS Signaling Pathway. [Abstract]

2017 Sep 4;6(9). pii: e006347. PMID: 28871042

MCC950 purchased from MedChemExpress. Usage Cited in: J Am Heart Assoc. 2017 Sep 4;6(9). pii: e006347. [Abstract]

Cells are pretreated with YVAD(10 μM) or MCC950 (10 μM) for 2 hours, and then exposed to TMAO (600 μM) for a further 24 hours. Expression of IL-1β, ICAM-1, MMP-9, and caspase-1 p20 is detected via Western blot.
Arab J Chem

2024 Jul 20.
Life Sci

Compressive stress induces cartilage endplate degeneration through the Piezo1/YAP-TEAD/NLRP3 axis. [Abstract]

2026 Mar 1:388:124195. PMID: 41506536
Commun Biol

Endoplasmic reticulum-mitochondria coupling prompts ZBP1-mediated RPE cell PANoptosis in age-related macular degeneration. [Abstract]

2025 Jul 29;8(1):1118. PMID: 40731132
Life Sci

Exploring the hepatoprotective effects of perillyl alcohol in the experimental models of acute liver injury. [Abstract]

2025 Aug 22:380:123926. PMID: 40850494
Life Sci

C3aR contributes to unilateral ureteral obstruction-induced renal interstitial fibrosis via the activation of the NLRP3 inflammasome. [Abstract]

2022 Nov 1:308:120905. PMID: 36041502
Life Sci

Hydrogen sulfide reduces pyroptosis and alleviates ischemia-reperfusion-induced acute kidney injury by inhibiting NLRP3 inflammasome. [Abstract]

2021 Nov 1:284:119466. PMID: 33811893
Life Sci

Autophagy alleviates mitochondrial DAMP-induced acute lung injury by inhibiting NLRP3 inflammasome. [Abstract]

2021 Jan 15;265:118833. PMID: 33275990
Life Sci

Rapamycin and MCC950 modified gut microbiota in experimental autoimmune encephalomyelitis mouse by brain gut axis. [Abstract]

2020 Jul 15;253:117747. PMID: 32376270
Inflammation

Palmatine Attenuates Lipopolysaccharide-Induced Acute Lung Injury Via Suppression of NLRP3 Inflammasome Activation, Pyroptosis, and Metabolic Remodeling. [Abstract]

2025 Dec 20;49(1):11. PMID: 41420798
Immunology

TIM3/CEACAM1 pathway involves in myeloid-derived suppressor cells induced CD8+ T cells exhaustion and bone marrow inflammatory microenvironment in myelodysplastic syndrome. [Abstract]

2023 Feb;168(2):273-289. PMID: 35470423
CNS Neurosci Ther

Electroacupuncture ameliorates postoperative cognitive dysfunction and associated neuroinflammation via NLRP3 signal inhibition in aged mice. [Abstract]

2022 Mar;28(3):390-400. PMID: 34951130
Immunology

NLR family pyrin domain containing 3 (NLRP3) and caspase 1 (CASP1) modulation by intracellular Cl- concentration. [Abstract]

2021 Aug;163(4):493-511. PMID: 33835494
Biofactors

Dihydromyricetin inhibits NLRP3 inflammasome-dependent pyroptosis by activating the Nrf2 signaling pathway in vascular endothelial cells. [Abstract]

2018 Mar;44(2):123-136. PMID: 29193391

MCC950 purchased from MedChemExpress. Usage Cited in: Biofactors. 2018 Mar;44(2):123-136. [Abstract]

NLRP3, Casp1 p20, IL-1b, and ICAM-1 protein levels are assessed in the cell lysates by Western blotting.
J Affect Disord

Ketamine ameliorates postpartum depression-like behaviors in rats exposed to sevoflurane during pregnancy through the AMPK/SIRT1/NLRP3 pathway. [Abstract]

2026 Jun 15:403:121439. PMID: 41698615
PLoS Pathog

African swine fever virus pEP364R acts as an important inflammatory-inducing factor to activate NLRP3 inflammasome-mediated pyroptosis by regulating DDX3X. [Abstract]

2026 Feb 25;22(2):e1013874. PMID: 41739885
Int J Mol Sci

PCSK9 Enhances Cardiac Fibrogenesis via the Activation of Toll-like Receptor and NLRP3 Inflammasome Signaling. [Abstract]

2025 Feb 23;26(5):1921. PMID: 40076547
J Nutr Biochem

Genistein upregulates AHR to protect against environmental toxin-induced NASH by inhibiting NLRP3 inflammasome activation and reconstructing antioxidant defense mechanisms. [Abstract]

2023 Nov:121:109436. PMID: 37666477
Int J Mol Sci

S100A4 Promotes BCG-Induced Pyroptosis of Macrophages by Activating the NF-κB/NLRP3 Inflammasome Signaling Pathway. [Abstract]

2023 Aug 11;24(16):12709. PMID: 37628889
Int J Mol Sci

Endoplasmic Reticulum Stress Mediated NLRP3 Inflammasome Activation and Pyroptosis in THP-1 Macrophages Infected with Bacillus Calmette-Guérin. [Abstract]

2023 Jul 20;24(14):11692. PMID: 37511451
Int J Mol Sci

Vitamin A Promotes the Fusion of Autophagolysosomes and Prevents Excessive Inflammasome Activation in Dextran Sulfate Sodium-Induced Colitis. [Abstract]

2023 May 12;24(10):8684. PMID: 37240022
Int J Mol Sci

Hyperglycemia Aggravates Periodontitis via Autophagy Impairment and ROS-Inflammasome-Mediated Macrophage Pyroptosis. [Abstract]

2023 Mar 27;24(7):6309. PMID: 37047282

MCC950 purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2023 Mar 27;24(7):6309. [Abstract]

MCC950 (5 μM; every other day for four weeks) significantly decreases CD68⁺ and GSDMD⁺ cells in rats.
Int J Mol Sci

Blockage of KHSRP-NLRP3 by MCC950 Can Reverse the Effect of Manganese-Induced Neuroinflammation in N2a Cells and Rat Brain. [Abstract]

2022 Oct 30;23(21):13224. PMID: 36362011
Pharmaceuticals (Basel)

Integrating Network Pharmacology and Experimental Validation to Explore the Effect and Mechanism of Inonotus obliquus Polysaccharide in the Treatment of Rheumatoid Arthritis. [Abstract]

2025 Jul 8;18(7):1017. PMID: 40732305
Front Pharmacol

Cyclovirobuxine D Ameliorates Experimental Diabetic Cardiomyopathy by Inhibiting Cardiomyocyte Pyroptosis via NLRP3 in vivo and in vitro. [Abstract]

2022 Jul 5:13:906548. PMID: 35865939
Front Pharmacol

Pharmacological Basis for Use of a Novel Compound in Hyperuricemia: Anti-Hyperuricemic and Anti-Inflammatory Effects. [Abstract]

2021 Nov 8:12:772504. PMID: 34819865
Front Pharmacol

Total Flavones of Abelmoschus manihot Ameliorates Podocyte Pyroptosis and Injury in High Glucose Conditions by Targeting METTL3-Dependent m6A Modification-Mediated NLRP3-Inflammasome Activation and PTEN/PI3K/Akt Signaling. [Abstract]

2021 Jul 15:12:667644. PMID: 34335245
Front Pharmacol

Calcipotriol Inhibits NLRP3 Signal Through YAP1 Activation to Alleviate Cholestatic Liver Injury and Fibrosis. [Abstract]

2020 Mar 31;11:200. PMID: 32296329
Eur J Pharmacol

Blockade of KCa3.1 ameliorates rheumatoid arthritis by suppressing macrophage M1 polarization via the NLRP3 inflammasome signaling pathway. [Abstract]

2026 Mar 28:1019:178738. PMID: 41794275
Int Immunopharmacol

NLRP3 and CCR1 drive offspring asthma susceptibility following maternal RSV infection. [Abstract]

2026 May 1:176:116478. PMID: 41825208
Int Immunopharmacol

IL-5 promotes airway remodeling in asthma by mediating epithelial-mesenchymal transition via the AKT/NLRP3 pathway. [Abstract]

2026 Apr 15:175:116422. PMID: 41759267
Int Immunopharmacol

Oridonin downregulates PD-L1 expression and promotes anti-tumor immunity via inhibiting NLRP3 and STAT3. [Abstract]

2026 Apr 15:175:116423. PMID: 41740339
Int Immunopharmacol

α-Methylene-γ-butyrolactone 3 inhibits the activation of NLRP3 inflammasome in sepsis by blocking both the priming and inflammasome assembly. [Abstract]

2026 Mar 15:173:116305. PMID: 41628514
Int Immunopharmacol

High-cholesterol-load-triggered pyroptosis of gingival fibroblasts promotes periodontitis. [Abstract]

2026 Apr 1:174:116259. PMID: 41707588
Bioorg Chem

Aucubin attenuates neonatal hypoxic-ischemic brain injury by suppressing NLRP3 inflammasome-mediated microglial pyroptosis. [Abstract]

2026 Jan:168:109332. PMID: 41365065
Int Immunopharmacol

Early P2X7 receptor activation mitigates neonatal group B Streptococcus infection severity and long-term neurodevelopmental impairment. [Abstract]

2025 Dec 30:171:116113. PMID: 41475282
Int Immunopharmacol

Baicalin inhibits Listeria monocytogenes-induced embryonic loss through the JNK/NEK7-NLRP3/GSDMD pathway. [Abstract]

2026 Jan 1;168(Pt 2):115921. PMID: 41289943
Int Immunopharmacol

Colistin-induced acute kidney injury via zinc Dyshomeostasis-triggered GSDMD-executed Pyroptosis. [Abstract]

2026 Jan 1;168(Pt 1):115768. PMID: 41176907
Int Immunopharmacol

STING knockdown blocks disease progression and inflammation in mice with alcoholic liver disease by relieving pyroptosis via suppressing NLRP3. [Abstract]

2026 Jan 1;168(Pt 2):115858. PMID: 41265219
Int Immunopharmacol

Crocin facilitates peripheral nerve regeneration through modulation of the STAT3/Bcl-2/Beclin-1 signaling axis-mediated autophagic pathway. [Abstract]

2025 Sep 5:165:115437. PMID: 40913861
Int Immunopharmacol

Oridonin alleviates SiNPs-induced pulmonary fibrosis by inhibiting pyroptosis via IRE1α-XBP1s-NLRP3 pathway. [Abstract]

2025 Aug 21:164:115388. PMID: 40845545
Int Immunopharmacol

AFB1 exacerbates testicular and intestinal inflammation by increasing stearoyl ethanolamide and homocysteine levels. [Abstract]

2025 May 26:159:114943. PMID: 40424650
Int Immunopharmacol

Mitigating PCOS progression: The protective effect of C-phycocyanin on ovarian granulosa cell pyroptosis via the NRF2/NLRP3/GSDMD pathway. [Abstract]

2025 May 23:159:114917. PMID: 40412127
Int Immunopharmacol

Tetrabromobisphenol S (TBBPS) exposure induced the testicular aging through NLRP3-mediated inflammatory signaling pathway in vitro and in vivo. [Abstract]

2025 Apr 16:152:114476. PMID: 40090078
Eur J Pharmacol

Targeting the ALKBH5-NLRP3 positive feedback loop alleviates cardiomyocyte pyroptosis after myocardial infarction. [Abstract]

2024 Dec 31:177247. PMID: 39746531
Int Immunopharmacol

Long non-coding RNA NRIR inhibits osteogenesis in peri-implantitis by promoting NLRP3 inflammasome-mediated macrophage pyroptosis. [Abstract]

2025 Jan 27:148:114180. PMID: 39874847
Int Immunopharmacol

Genome-wide screen based on 2DG activated NLRP3 inflammasome reveals the priming signal of TLR2/4 to IKKβ but not IKKα. [Abstract]

2024 Dec 9:145:113781. PMID: 39657538
Int Immunopharmacol

The role of lncRNA NEAT1 in acute graft-versus-host disease: Regulation of macrophage polarization and inflammatory cytokine secretion via JNK/NLRP3 pathway. [Abstract]

2024 Dec 24:146:113857. PMID: 39721453
Int Immunopharmacol

Progesterone suppresses rhinovirus-induced airway inflammation by inhibiting neutrophil infiltration and extracellular traps formation. [Abstract]

2024 Dec 2:144:113714. PMID: 39626540
Int Immunopharmacol

Pyroptosis mediated by Parkin-NLRP3 negative feedback loop contributed to Parkinson's disease induced by rotenone. [Abstract]

2024 Nov 15;143(Pt 3):113608. PMID: 39549548
Int Immunopharmacol

MCC950 promotes diabetic wound healing through modulating macrophage polarization in an MDSC-dependent manner. [Abstract]

2024 Aug 31;142(Pt A):112983. PMID: 39217887
Int Immunopharmacol

AdipoRon exerts an antidepressant effect by inhibiting NLRP3 inflammasome activation in microglia via promoting mitophagy. [Abstract]

2024 Aug 29:141:113011. PMID: 39213872
Invest Ophthalmol Vis Sci

Involvement of cGAS/STING Signaling in the Pathogenesis of Candida albicans Keratitis: Insights From Genetic and Pharmacological Approaches. [Abstract]

2024 Jun 3;65(6):13. PMID: 38848078
Int Immunopharmacol

Renoprotective effect of rosmarinic acid by inhibition of indoxyl sulfate-induced renal interstitial fibrosis via the NLRP3 inflammasome signaling. [Abstract]

2024 May 23:135:112314. PMID: 38788450
Int Immunopharmacol

Oridonin exerts anticonvulsant profile and neuroprotective activity in epileptic mice by inhibiting NLRP3-mediated pyroptosis. [Abstract]

2024 May 16:134:112247. PMID: 38759374
Eur J Pharmacol

Inhibition of spinal BRD4 alleviates pyroptosis and M1 microglia polarization via STING-IRF3 pathway in morphine-tolerant rats. [Abstract]

2024 Apr 15:969:176428. PMID: 38432572
Int Immunopharmacol

Extracellular ATP contributes to the reactive oxygen species burst and exaggerated mitochondrial damage in D-galactosamine and lipopolysaccharide-induced fulminant hepatitis. [Abstract]

2024 Mar 30:130:111680. PMID: 38368772
Eur J Pharmacol

Direct inhibition of microglial activation by a μ receptor selective agonist alleviates inflammatory-induced pain hypersensitivity. [Abstract]

2023 Dec 15:961:176182. PMID: 37951488
Int Immunopharmacol

Pyroptosis of chondrocytes activated by synovial inflammation accelerates TMJ osteoarthritis cartilage degeneration via ROS/NLRP3 signaling. [Abstract]

2023 Aug 23;124(Pt A):110781. PMID: 37625369
Int Immunopharmacol

CXCL5 promotes lipotoxicity of hepatocytes through upregulating NLRP3/Caspase-1/IL-1β signaling in Kupffer cells and exacerbates nonalcoholic steatohepatitis in mice. [Abstract]

2023 Oct:123:110752. PMID: 37573690
Int Immunopharmacol

GATA6 promotes fibrotic repair of tracheal injury through NLRP3 inflammasome-mediated epithelial pyroptosis. [Abstract]

2023 Oct:123:110657. PMID: 37531826
Invest Ophthalmol Vis Sci

SIRT1 Inhibits High Glucose-Induced TXNIP/NLRP3 Inflammasome Activation and Cataract Formation. [Abstract]

2023 Mar 1;64(3):16. PMID: 36881408
Int Immunopharmacol

Sustained activation of NLRP3 inflammasome contributes to delayed wound healing in aged mice. [Abstract]

2023 Mar:116:109828. PMID: 36774855
Int Immunopharmacol

Trophoblastic mitochondrial DNA induces endothelial dysfunction and NLRP3 inflammasome activation: Implications for preeclampsia. [Abstract]

2023 Jan:114:109523. PMID: 36508916
Eur J Pharmacol

The selective NLRP3 inflammasome inhibitor MCC950 improves isoproterenol-induced cardiac dysfunction by inhibiting cardiomyocyte senescence. [Abstract]

2022 Dec 15:937:175364. PMID: 36336012
Int Immunopharmacol

Co-activation of Caspase-1 and Caspase-8 in CMV-induced SGN death by inflammasome-associated pyroptosis and apoptosis. [Abstract]

2022 Dec;113(Pt A):109305. PMID: 36244217
Int Immunopharmacol

Ursolic acid alleviates Kupffer cells pyroptosis in liver fibrosis by the NOX2/NLRP3 inflammasome signaling pathway. [Abstract]

2022 Dec;113(Pt A):109321. PMID: 36252479
Int Immunopharmacol

Activation of NLRP3 inflammasome contributes to the inflammatory response to allergic rhinitis via macrophage pyroptosis. [Abstract]

2022 Sep:110:109012. PMID: 35809382
Invest Ophthalmol Vis Sci

The NLRP3 Activation in Infiltrating Macrophages Contributes to Corneal Fibrosis by Inducing TGF-β1 Expression in the Corneal Epithelium. [Abstract]

2022 Jul 8;63(8):15. PMID: 35838447
Int Immunopharmacol

Psoralidin, a major component of Psoraleae Fructus, induces inflammasome activation and idiosyncratic liver injury. [Abstract]

2021 Mar:92:107352. PMID: 33422760
Toxicology

PM2.5 exposure exacerbates airway pyroptosis related inflammatory response in asthmatic mice by activating NLRP3 inflammasome. [Abstract]

2025 Dec 18:521:154376. PMID: 41421518
Molecules

Constituents from Dolichos lablab L. Flowers and Their Anti-Inflammatory Effects via Inhibition of IL-1β Release. [Abstract]

2024 Aug 7;29(16):3751. PMID: 39202831
Molecules

MCC950 Ameliorates Diabetic Muscle Atrophy in Mice by Inhibition of Pyroptosis and Its Synergistic Effect with Aerobic Exercise. [Abstract]

2024 Feb 4;29(3):712. PMID: 38338456
Molecules

Trimethylamine N-Oxide (TMAO) Inducing Endothelial Injury: UPLC-MS/MS-Based Quantification and the Activation of Cathepsin B-Mediated NLRP3 Inflammasome. [Abstract]

2023 Apr 29;28(9):3817. PMID: 37175227
Molecules

Downregulation of the NLRP3/Caspse-1 Pathway Ameliorates Ketamine-Induced Liver Injury and Inflammation in Developing Rats. [Abstract]

2022 May 4;27(9):2931. PMID: 35566282
Toxicology

Zearalenone induces NLRP3-dependent pyroptosis via activation of NF-κB modulated by autophagy in INS-1 cells. [Abstract]

2019 Dec 1;428:152304. PMID: 31586597
Molecules

Inhibiting the NLRP3 Inflammasome Activation with MCC950 Ameliorates Diabetic Encephalopathy in db/db Mice. [Abstract]

2018 Feb 27;23(3). pii: E522. PMID: 29495433

MCC950 purchased from MedChemExpress. Usage Cited in: Molecules. 2018 Feb 27;23(3). pii: E522. [Abstract]

Effects of MCC950 on hippocampal NLRP3 inflammasome activation in db/db mice. Western blot analysis of NLRP3 inflammasome-associated NLRP3, ASC, IL-1β, and β-actin are performed in the hippocampus of each group.
Probiotics Antimicrob Proteins

Bifidobacterium breve BBr60 Enhances SCFA Levels and Restores NLRP3/NLRP6 Balance in the Gut to Improve Motor Deficits in PD Mice. [Abstract]

2025 Jun 6. PMID: 40478433
Immunotargets Ther

NLRP3 Inflammasome Upregulates PD-L1 in Ovarian Cancer and Contributes to an Immunosuppressive Microenvironment. [Abstract]

2024 Dec 14:13:775-788. PMID: 39703562
Mol Neurobiol

NLRP3 Inflammasome Activation Contributes to Seizure Susceptibility in Anti-NMDAR Encephalitis: Evidence from Patients and a Mouse Model. [Abstract]

2025 Nov 11;63(1):25. PMID: 41217696
Mol Neurobiol

PD-1 Attenuates Neuropathic Pain by Ameliorating NLRP3 Inflammasome-Mediated Microglia Pyroptosis. [Abstract]

2025 Jul 19. PMID: 40682720
Mol Neurobiol

Huang-Pu-Tong-Qiao Formula Alleviates Hippocampal Neuron Damage by Inhibiting NLRP3 Inflammasome-mediated Pyroptosis in Alzheimer's Disease. [Abstract]

2025 Apr;62(4):4545-4561. PMID: 39466576
Aquat Toxicol

Perfluorooctane sulfonate causes pyroptosis and lipid metabolism disorders through ROS-mediated NLRP3 inflammasome activation in grass carp hepatocyte. [Abstract]

2024 Feb:267:106839. PMID: 38228041
Mol Neurobiol

Inhibiting the NLRP3 Inflammasome with MCC950 Alleviates Neurological Impairment in the Brain of EAE Mice. [Abstract]

2024 Mar;61(3):1318-1330. PMID: 37702910
Front Cell Dev Biol

Long Non-coding RNA MEG3 Promotes Pyroptosis in Testicular Ischemia-Reperfusion Injury by Targeting MiR-29a to Modulate PTEN Expression. [Abstract]

2021 Jun 18:9:671613. PMID: 34222244
Front Cell Dev Biol

Targeting TFE3 Protects Against Lysosomal Malfunction-Induced Pyroptosis in Random Skin Flaps via ROS Elimination. [Abstract]

2021 Apr 8:9:643996. PMID: 33898433
FASEB J

The Mechanism of Action of NMN in Inhibiting NLRP3 Acetylation-Mediated Granulosa Cell Pyroptosis to Improve Ovarian Reserve Function in Ionizing Radiation-Exposed Mice. [Abstract]

2025 Dec 31;39(24):e71335. PMID: 41395774
J Cell Mol Med

TGFBI Inhibits the Pyroptosis of Macrophages to Ameliorate Septic Shock. [Abstract]

2025 Oct;29(19):e70802. PMID: 41078093
FASEB J

TREM-1 Promotes Microglial Pyroptosis and Mitochondrial Fission in Intracerebral Hemorrhage via the PI3K/AKT Pathway. [Abstract]

2025 Oct 15;39(19):e71115. PMID: 41065767
FASEB J

STING Facilitates Vascular Calcification via p-STAT1/NLRP3 Signal. [Abstract]

2025 Apr 15;39(7):e70530. PMID: 40193045
Biochim Biophys Acta Mol Basis Dis

PLUNC inhibits invasion and metastasis in nasopharyngeal carcinoma by inhibiting NLRP3 inflammasome activation. [Abstract]

2024 Jul 12:167352. PMID: 39004379
J Clin Transl Hepatol

Mitochondrial GRIM19 Loss Induces Liver Fibrosis through NLRP3/IL33 Activation via Reactive Oxygen Species/NF-кB Signaling. [Abstract]

2024 Jun 28;12(6):539-550. PMID: 38974954
Exp Neurol

Inhibiting the IRAK4/NF-κB/NLRP3 signaling pathway can reduce pyroptosis in hippocampal neurons and seizure episodes in epilepsy. [Abstract]

2024 Jul:377:114794. PMID: 38685307
Mediators Inflamm

Cryptotanshinone Inhibits Bladder Cancer Cell Malignant Progression in a Lipopolysaccharide-Induced Inflammatory Microenvironment through NLRP3 Inhibition. [Abstract]

2024 Jan 30:2024:8828367. PMID: 39144184
Exp Neurol

Hydrogen sulfide ameliorates lipopolysaccharide-induced anxiety-like behavior by inhibiting checkpoint kinase 1 activation in the hippocampus of mice. [Abstract]

2024 Jan:371:114586. PMID: 37898396
Poultry Sci

Hydroxytyrosol mitigates Mycoplasma gallisepticum-induced pulmonary injury through downregulation of the NF-κB/NLRP3/IL-1β signaling pathway in chicken. [Abstract]

2023 May;102(5):102582. PMID: 36940652
Environ Toxicol Pharmacol

Annexin A1 inhibition facilitates NLRP3 inflammasome activation in arsenic-induced insulin resistance in rat liver. [Abstract]

2022 Nov:96:103981. PMID: 36182042
Bioengineered

Crosstalk of pyroptosis, ferroptosis, and mitochondrial aldehyde dehydrogenase 2-related mechanisms in sepsis-induced lung injury in a mouse model. [Abstract]

2022 Mar;13(3):4810-4820. PMID: 35188436
Microorganisms

Lactobacillus johnsonii L531 Alleviates the Damage Caused by Salmonella Typhimurium via Inhibiting TLR4, NF-κB, and NLRP3 Inflammasome Signaling Pathways. [Abstract]

2021 Sep 17;9(9):1983. PMID: 34576878
Ther Adv Med Oncol

Methotrexate enhances antigen presentation and maturation of tumour antigen-loaded dendritic cells through NLRP3 inflammasome activation: a strategy for dendritic cell-based cancer vaccine. [Abstract]

2021 Jan 21:13:1758835920987056. PMID: 33613696
J Inflamm Res

MCC950 Alleviates Experimental Autoimmune Neuritis by Inhibiting NLRP3 Inflammasome Activity and Down-Regulating Interleukin-23/Interleukin-17 Axis Expression. [Abstract]

2025 Dec 6:18:17113-17127. PMID: 41394901
Toxics

Mechanistic Studies on the Role of IL-17/NLRP3 in Arsenic-Induced Activation of Hepatic Stellate Cells Through Hepatocyte Proptosis. [Abstract]

2025 Apr 9;13(4):287. PMID: 40278603
J Inflamm Res

Cigarette Smoking Induces Skeletal Muscle Atrophy in Mice by Activated Macrophage-Mediated Pyroptosis. [Abstract]

2025 Feb 19:18:2447-2464. PMID: 39991657
J Hypertens

CTRP3 inhibits myocardial fibrosis through the P2X7R-NLRP3 inflammasome pathway in SHR rats. [Abstract]

2024 Feb 1;42(2):315-328. PMID: 37850974
iScience

Induced neural stem cells suppressed neuroinflammation by inhibiting the microglial pyroptotic pathway in intracerebral hemorrhage rats. [Abstract]

2023 Jun 7;26(7):107022. PMID: 37360683
J Inflamm Res

Neutrophil Extracellular Traps Induce Alveolar Macrophage Pyroptosis by Regulating NLRP3 Deubiquitination, Aggravating the Development of Septic Lung Injury. [Abstract]

2023 Feb 27:16:861-877. PMID: 36876152
Toxics

Ginsenoside Rg1 Mitigates Porcine Intestinal Tight Junction Disruptions Induced by LPS through the p38 MAPK/ NLRP3 Inflammasome Pathway. [Abstract]

2022 May 27;10(6):285. PMID: 35736894
J Inflamm Res

Regulation of the Immune Microenvironment by an NLRP3 Inhibitor Contributes to Attenuation of Acute Right Ventricular Failure in Rats with Pulmonary Arterial Hypertension. [Abstract]

2021 Nov 2;14:5699-5711. PMID: 34754216
Toxins

Pyroptosis of Macrophages Induced by Clostridium perfringens Beta-1 Toxin. [Abstract]

2023 May 29;15(6):366. PMID: 37368667
J Funct Foods

2023 Jun, 105, 105582.
J Funct Foods

2023 Feb.
J Funct Foods

2023, 100: 105386.
J Funct Foods

December 2020, 104274.
Sci Rep

I-BET151 modulates NLRP3 inflammasome-mediated pyroptosis and exhibits anti-inflammatory activity. [Abstract]

2025 Dec 3;16(1):994. PMID: 41339462
Sci Rep

MCC950 targets the ROS-NEK7-NLRP3 axis to improve type 2 diabetic retinopathy. [Abstract]

2025 Sep 23;15(1):32637. PMID: 40987781
Sci Rep

HIIT and MICT mitigate endothelial dysfunction in early atherosclerotic mice via PCSK9 inhibition. [Abstract]

2025 Aug 19;15(1):30411. PMID: 40830352
Sci Rep

RBPMS2 can inhibit the NLRP3 / caspase-1 / GSDMD signaling pathway to resist pyroptosis in gastric cancer cells. [Abstract]

2025 Jul 1;15(1):21294. PMID: 40595708
Sci Rep

The role and mechanism of lung microbiota in coal mine dust-induced NLRP3 inflammasome upregulate and lung injury. [Abstract]

2025 Jul 2;15(1):22990. PMID: 40594884
Sci Rep

Ocifisertib alleviates the gasdermin D-independent pyroptosis of nucleus pulposus cells by targeting GSDME. [Abstract]

2025 Apr 17;15(1):13280. PMID: 40247083
Sci Rep

S100 calcium-binding protein A8 exacerbates deep vein thrombosis in vascular endothelial cells. [Abstract]

2025 Jan 4;15(1):831. PMID: 39755911
J Endocrinol

β2AR against myocarditis-lipid deposition depends on estrogenic environment in stress. [Abstract]

2023 Feb 16;256(3):e220335. PMID: 36633355
Aging (Albany NY)

NLRP3 inflammasome activation contributes to the pathogenesis of cardiocytes aging. [Abstract]

2021 Aug 25;13(16):20534-20551. PMID: 34432650
Microbiol Spectr

Inhibiting NLRP3 enhances cellular autophagy induced by outer membrane vesicles from Pseudomonas aeruginosa. [Abstract]

2025 Jan 28:e0181924. PMID: 39873509
Clin Exp Immunol

Neutrophil extracellular traps induce pyroptosis of pulmonary microvascular endothelial cells by activating the NLRP3 inflammasome. [Abstract]

2024 Jun 20;217(1):89-98. PMID: 38517050
Clin Immunol

STING contributes to trauma-induced heterotopic ossification through NLRP3-dependent macrophage pyroptosis. [Abstract]

2023 May:250:109300. PMID: 36963448
Neurochem Res

Liraglutide Ameliorates Cerebral Ischemia in Mice via Antipyroptotic Pathways. [Abstract]

2022 Jul;47(7):1904-1916. PMID: 35352213
Microbiol Spectr

Senecavirus a 3D Interacts with NLRP3 to Induce IL-1β Production by Activating NF-κB and Ion Channel Signals. [Abstract]

2022 Apr 27;10(2):e0209721. PMID: 35254168
Clin Exp Immunol

NLRP3 inflammasome activation contributes to the pathogenesis of rheumatoid arthritis. [Abstract]

2018 Nov;194(2):231-243. PMID: 30277570

MCC950 purchased from MedChemExpress. Usage Cited in: Clin Exp Immunol. 2018 Nov;194(2):231-243. [Abstract]

MCC950 treatment inhibits Nucleotide-binding, oligomerization domain (NOD)-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome pathway activation.
Metabolites

Free Fatty Acids and Endotoxins Synergically Induce Pyroptosis in Bovine Hepatocytes. [Abstract]

2026 Jan 8;16(1):53. PMID: 41590661
Int Dent J

Inhibition of Dynamin-Related Protein 1-Dependent Mitochondrial Fission Ameliorates Apical Periodontitis by Attenuating NLRP3 Inflammasome-Mediated M1 Macrophage Polarisation. [Abstract]

2025 Jun 14;75(4):100853. PMID: 40517458
Brain Res Bull

Pharmacological inhibition of Kv1.3 channel reduces sevoflurane-induced cognitive impairment through NLRP3-dependent microglial modulation. [Abstract]

2025 Apr 17:111351. PMID: 40252702
Cell Signal

Rescuing fertility: Itaconic acid prevents ovarian damage through NRF2-mediated pyroptosis pathways in diminished ovarian reserve models. [Abstract]

2025 Mar 25:111766. PMID: 40147551
Biochim Biophys Acta Mol Cell Res

FOSL1 regulates hyperproliferation and NLRP3-mediated inflammation of psoriatic keratinocytes through the NF-kB signaling via transcriptionally activating TRAF3. [Abstract]

2024 Apr;1871(4):119689. PMID: 38367916
Biochim Biophys Acta Mol Cell Res

Modified 5-aminolevulinic acid photodynamic therapy induces cutaneous squamous cell carcinoma cell pyroptosis via the JNK signaling pathway. [Abstract]

2024 Jan;1871(1):119603. PMID: 37805058
Int J Neuropsychopharmacol

Albiflorin Attenuates Mood Disorders Under Neuropathic Pain State by Suppressing the Hippocampal NLRP3 Inflammasome Activation During Chronic Constriction Injury. [Abstract]

2021 Jan 20;24(1):64-76. PMID: 33000169
Neural Plast

Inhibition of NLRP3 Inflammasome Ameliorates Cerebral Ischemia-Reperfusion Injury in Diabetic Mice. [Abstract]

2018 Apr 24:2018:9163521. PMID: 29853850
Biochim Biophys Acta

The SGK1 inhibitor EMD638683, prevents Angiotensin II-induced cardiac inflammation and fibrosis by blocking NLRP3 inflammasome activation. [Abstract]

2017 Oct 3;1864(1):1-10. PMID: 28986310

MCC950 purchased from MedChemExpress. Usage Cited in: Biochim Biophys Acta. 2017 Oct 3;1864(1):1-10. [Abstract]

MCC950 or vehicle control (PBS) is administered at 1, 4 and 6 day after Ang II infusion in the absence or presence of EMD638683. Representative images and quantification of picrosirius red-stained collagen in the heart at 7 days after Ang II infusion.
Biochim Biophys Acta

A novel mechanism of diabetic vascular endothelial dysfunction: Hypoadiponectinemia-induced NLRP3 inflammasome activation. [Abstract]

2017 Feb 13;1863(6):1556-1567. PMID: 28216285
Mol Cell Endocrinol

NLRP3 blockade by MCC950 suppressed osteoclastogenesis via NF-κB/c-Fos/NFATc1 signal pathway and alleviated bone loss in diabetes mellitus. [Abstract]

2024 Dec 1:594:112382. PMID: 39349237
Heliyon

NLRP3 inhibitor combined with Yimusake improves erectile dysfunction in rats with diabetes mellitus through the attenuation of pyroptosis. [Abstract]

2024 Sep 27;10(19):e38626. PMID: 39391494
Heliyon

New compatible pair of TCM: Paeoniae Radix Alba effectively alleviate Psoraleae Fructus-induced liver injury by suppressing NLRP3 inflammasome activation. [Abstract]

2024 Jul 14;10(14):e34591. PMID: 39130485
Heliyon

Asprosin promotes vascular inflammation via TLR4-NFκB-mediated NLRP3 inflammasome activation in hypertension. [Abstract]

2024 May 23;10(11):e31659. PMID: 38841464
Heliyon

Shengmai injection inhibits palmitic acid-induced myocardial cell inflammatory death via regulating NLRP3 inflammasome activation. [Abstract]

2023 Nov 2;9(11):e21522. PMID: 38027923
Microb Pathog

Mechanism of tea saponin in alleviating intestinal damage induced by E. coli infection via the NF-κB/NLRP3 pathway. [Abstract]

2026 Apr:213:108326. PMID: 41605328
Viruses

H6N6 Avian Influenza Virus Infection Induced Pyroptosis of M1 Macrophages by Activating Caspase-1. [Abstract]

2025 Nov 12;17(11):1492. PMID: 41305513
Food Chem Toxicol

Targeting the MLKL-F-actin-NLRP3 axis attenuates arsenic-induced myocardial necroinflammation. [Abstract]

2025 Nov 21:208:115861. PMID: 41275903
Vet Res

PRRSV NSP5 orchestrates dual immune disruption by targeting NLRP3 and STING. [Abstract]

2025 Oct 16;56(1):199. PMID: 41102826
Biology (Basel)

7-Methoxyflavanone Alleviates LPS-Induced Acute Lung Injury by Suppressing TLR4/NF-κB p65 and ROS/Txnip/NLRP3 Signaling. [Abstract]

2025 Sep 2;14(9):1170. PMID: 41007315
Exp Cell Res

HMGB1 contributes to pancreatic fibrosis by regulating TLR4-mediated autophagy and the NLRP3 inflammasome pathway in chronic pancreatitis. [Abstract]

2025 Sep 1;452(1):114745. PMID: 40915340
Microb Pathog

C. albicans airway colonization amplifies inflammation in emphysema through the ROS/NLRP3 pathway of macrophages. [Abstract]

2025 Oct:207:107853. PMID: 40588176
Exp Cell Res

Exosomes derived from diabetic microenvironment-preconditioned mesenchymal stem cells ameliorate nonalcoholic fatty liver disease and inhibit pyroptosis of hepatocytes. [Abstract]

2024 Nov 7;443(2):114325. PMID: 39521106
Reprod Biomed Online

Blockage of the NLRP3 inflammasome by MCC950 inhibits migration and invasion in adenomyosis. [Abstract]

2024 Oct;49(4):104319. PMID: 39121559
Exp Cell Res

Pyroptosis inhibitors MCC950 and VX-765 mitigate myocardial injury by alleviating oxidative stress, inflammation, and apoptosis in acute myocardial hypoxia. [Abstract]

2024 Apr 30;438(2):114061. PMID: 38692345
Mol Med Rep

Dapagliflozin alleviates renal podocyte pyroptosis via regulation of the HO‑1/NLRP3 axis. [Abstract]

2023 Nov;28(5):200. PMID: 37711056
Food Chem Toxicol

Elaidic acid induced hepatocyte pyroptosis via autophagy-CTSB-NLRP3 pathway. [Abstract]

2023 Nov:181:114060. PMID: 37748573
Food Chem Toxicol

L-theanine attenuates porcine intestinal tight junction damage induced by LPS via p38 MAPK/NLRP3 signaling in IPEC-J2 cells. [Abstract]

2023 Aug:178:113870. PMID: 37271275
Parasit Vectors

A novel cysteine protease inhibitor in Baylisascaris schroederi migratory larvae regulates inflammasome activation through the TLR4-ROS-NLRP3 pathway. [Abstract]

2022 Sep 23;15(1):334. PMID: 36151570
Exp Cell Res

A20 inhibits periodontal bone resorption and NLRP3-mediated M1 macrophage polarization. [Abstract]

2022 Sep 1;418(1):113264. PMID: 35714941
Exp Cell Res

Role of NLR family pyrin domain-containing 3 inflammasome in the activation of pancreatic stellate cells. [Abstract]

2021 Jul 15;404(2):112634. PMID: 34004193
Food Chem Toxicol

Patulin induces pyroptosis through the autophagic-inflammasomal pathway in liver. [Abstract]

2021 Jan;147:111867. PMID: 33217525
Exp Cell Res

NLRP3 inflammasome inhibition attenuates cisplatin-induced renal fibrosis by decreasing oxidative stress and inflammation. [Abstract]

2019 Oct 1;383(1):111488. PMID: 31276670
Food Chem Toxicol

Inorganic arsenic induces pyroptosis and pancreatic β cells dysfunction through stimulating the IRE1α/TNF-α pathway and protective effect of taurine. [Abstract]

2019 Mar:125:392-402. PMID: 30660605
J Diabetes Res

Diabetic Cardiomyopathy Uncovered: Transcriptomics, NLRP3, and Carvedilol Mechanisms. [Abstract]

2024 Nov 23:2024:9378405. PMID: 39619569
Acta Biochim Biophys Sin (Shanghai)

NLRP3 inflammasome signal pathway involves in Vibrio harveyi-induced inflammatory response in murine peritoneal macrophages in vitro. [Abstract]

2021 Dec 8;53(12):1590-1601. PMID: 34569606
Cell Cycle

Atorvastatin inhibited TNF-α induced matrix degradation in rat nucleus pulposus cells by suppressing NLRP3 inflammasome activity and inducing autophagy through NF-κB signaling. [Abstract]

2021 Oct;20(20):2160-2173. PMID: 34494933
Biochim Biophys Acta Mol Cell Biol Lipids

Palmitic acid activates NLRP3 inflammasome through NF-κB and AMPK-mitophagy-ROS pathways to induce IL-1β production in large yellow croaker (Larimichthys crocea). [Abstract]

2024 Mar;1869(2):159428. PMID: 38029958
Front Oncol

Antidiabetic DPP-4 Inhibitors Reprogram Tumor Microenvironment That Facilitates Murine Breast Cancer Metastasis Through Interaction With Cancer Cells via a ROS-NF-кB-NLRP3 Axis. [Abstract]

2021 Sep 24:11:728047. PMID: 34631556
Arch Med Sci

2021 Mar.
Am J Physiol Gastrointest Liver Physiol

Mitochondrial DNA enables AIM2 inflammasome activation and hepatocyte pyroptosis in nonalcoholic fatty liver disease. [Abstract]

2021 Jun 1;320(6):G1034-G1044. PMID: 33728991
World J Tradit Chin Med

2026 Jan 14.
Cell Stress Chaperones

Involvement of oxidative stress-AMPK-Cx43-NLRP3 pathway in extracellular matrix remodeling of gastric smooth muscle cells in rats with diabetic gastroparesis. [Abstract]

2024 Jun;29(3):440-455. PMID: 38653383
Int Immunol

IL-27 regulates NLRP3 inflammasome activation of MDSCs in experimental Sjögren's syndrome. [Abstract]

2023 Nov 7;35(11):531-542. PMID: 37756640
Int J Cardiol

H2S alleviates aortic aneurysm and dissection: Crosstalk between transforming growth factor 1 signaling and NLRP3 inflammasome. [Abstract]

2021 Sep 1:338:215-225. PMID: 34157359
Int J Med Sci

Ginsenoside Rg1 alleviates acute liver injury through the induction of autophagy and suppressing NF-κB/NLRP3 inflammasome signaling pathway. [Abstract]

2021 Jan 23;18(6):1382-1389. PMID: 33628094
Front Psychiatry

Leptin Increases Expression of 5-HT2B Receptors in Astrocytes Thus Enhancing Action of Fluoxetine on the Depressive Behavior Induced by Sleep Deprivation. [Abstract]

2019 Jan 7;9:734. PMID: 30666218
Naunyn Schmiedebergs Arch Pharmacol

Integration of network pharmacology and transcriptomics to reveal the ROS/NLRP3/Caspase-1/GSDMD-mediated mechanism of baicalin in alleviating contrast-induced acute kidney injury. [Abstract]

2025 Dec 12. PMID: 41384955
Kaohsiung J Med Sci

Total saponins of Aralia elata (Miq.) Seem. alleviate myocardial ischemia-reperfusion injury by promoting NLRP3-inflammasome inactivation via PI3K/Akt signaling. [Abstract]

2023 Mar;39(3):290-301. PMID: 36408810
PPAR Res

Rosiglitazone Alleviates Mechanical Allodynia of Rats with Bone Cancer Pain through the Activation of PPAR- γ to Inhibit the NF- κ B/NLRP3 Inflammatory Axis in Spinal Cord Neurons. [Abstract]

2021 Aug 25:2021:6086265. PMID: 34484316
Naunyn Schmiedebergs Arch Pharmacol

RETRACTED ARTICLE: Physcion 8-O-β-glucopyranoside mediates the NLRP3-associated pyroptosis and cell metastasis in the human osteosarcoma cells via ER stress activation. [Abstract]

2021 Mar;394(3):555. PMID: 32072190
Curr Res Toxicol

The NLRP3 inhibitor, MCC950, attenuates environmental pollutant PM2.5-induced acute lung injury by inhibiting alveolar macrophage pyroptosis. [Abstract]

2026 Jan 22:10:100282. PMID: 41743188
Mol Immunol

Curcumin mitigates testicular ischemia-reperfusion injury by suppressing NLRP3-mediated pyroptosis. [Abstract]

2025 Sep:185:71-80. PMID: 40706257
J Tradit Complement Med

Xin-Li formula attenuates heart failure induced by a combination of hyperlipidemia and myocardial infarction in rats via Treg immunomodulation and NLRP3 inflammasome inhibition. [Abstract]

2023 Mar 29;13(5):441-453. PMID: 37693100

MCC950 purchased from MedChemExpress. Usage Cited in: J Tradit Complement Med. 2023 Mar 29;13(5):441-453. [Abstract]

MCC950 (10 μM; 1 h) inhibits the expression of NLRP3 in THP-1 cells.
Arch Biochem Biophys

Increased mitochondrial fission induces NLRP3/cGAS-STING mediated pro-inflammatory pathways and apoptosis in UVB-irradiated immortalized human keratinocyte HaCaT cells. [Abstract]

2023 Apr:738:109558. PMID: 36878340
Mol Immunol

Idebenone attenuates cerebral inflammatory injury in ischemia and reperfusion via dampening NLRP3 inflammasome activity. [Abstract]

2020 Jul;123:74-87. PMID: 32438202
3 Biotech

Aloe-emodin attenuates Aβ25-35-induced HT22 cell pyroptosis via inhibiting NLRP3 inflammasome pathway. [Abstract]

2026 Feb;16(2):71. PMID: 41550486
3 Biotech

Mitochondria-mediated pyroptosis: anti-glioblastoma mechanism of the frankincense-derived compound β-boswellic acid. [Abstract]

2026 Feb;16(2):73. PMID: 41550484
3 Biotech

Tao Hong Si Wu decoction attenuates myocardial injury in diabetic mice by regulating the cGAS/STING/NLRP3 axis. [Abstract]

2025 Dec;15(12):413. PMID: 41250668
Burns

Nucleotide-binding domain-like receptor protein 3 inflammasome contributes to vascular endothelial barrier dysfunction and shock after burn injury. [Abstract]

2025 Jun 27;51(7):107589. PMID: 40651119
Pflugers Arch

Targeting NLRP3 inflammasome attenuates cardiac pyroptosis and fibrosis in estrogen-deficient diabetic rats. [Abstract]

2025 Jul;477(7):935-952. PMID: 40383837
Pflugers Arch

Interleukin-1β in hypothalamic paraventricular nucleus mediates excitatory renal reflex. [Abstract]

2020 Nov;472(11):1577-1586. PMID: 32915316
Mol Biol Rep

Microglial NLRP3 inflammasome activation leads to perineuronal net loss in cocultured neurons. [Abstract]

2025 Oct 13;52(1):1023. PMID: 41082132
J Cell Biochem

Rapamycin combined with MCC950 to treat multiple sclerosis in experimental autoimmune encephalomyelitis. [Abstract]

2019 Apr;120(4):5160-5168. PMID: 30320900
Exp Eye Res

TLR9-mediated activation of the NLRP3 inflammasome in Fusarium solani-induced keratitis. [Abstract]

2026 Apr:265:110867. PMID: 41548834
Vet Microbiol

The critical role of NLRP3 inflammasome activation in Streptococcus suis-induced blood-brain barrier disruption. [Abstract]

2024 Jun 21:295:110161. PMID: 38945021
Exp Biol Med

TXNIP activates NLRP3/IL-1β and participate in inflammatory response and oxidative stress to promote deep venous thrombosis. [Abstract]

2023 Sep;248(18):1588-1597. PMID: 37749991
Exp Eye Res

Topical calcitriol application promotes diabetic corneal wound healing and reinnervation through inhibiting NLRP3 inflammasome activation. [Abstract]

2021 Aug:209:108668. PMID: 34144035
Vet Microbiol

ATP-dependent activation of NLRP3 inflammasome in primary murine macrophages infected by pseudorabies virus. [Abstract]

2021 Aug:259:109130. PMID: 34052623
PLoS One

Impact of blast exposure on visual pathway: Mechanism exploration and novel diagnostic perspectives. [Abstract]

2026 Mar 25;21(3):e0344993. PMID: 41880282
Endocrinol Diabetes Metab

Targeting the NEK7/NLRP3 Inflammasome Axis: Synergistic Protection of Intravitreal MCC950 and Systemic Metformin Against Diabetic Retinopathy in Rats. [Abstract]

2026 Jan;9(1):e70151. PMID: 41588940
PLoS One

Inhibition of TREM1 attenuates myocardial ischemia-reperfusion injury-induced cardiomyocyte pyroptosis by suppressing the activation of the NF-κB signaling pathway. [Abstract]

2026 Jan 9;21(1):e0340382. PMID: 41511954
Fitoterapia

The processed Euphorbia lathyris L. alleviates the inflammatory injury via regulating LXRα/ABCA1 expression and TLR4 positioning to lipid rafts. [Abstract]

2024 Jul 4:106111. PMID: 38971330
Platelets

Platelet-derived microparticles stimulated by anti-β2GPI/β2GPI complexes induce pyroptosis of endothelial cells in antiphospholipid syndrome. [Abstract]

2023 Dec;34(1):2156492. PMID: 36550078
Brain Res

Sulforaphane attenuates microglia-mediated neuronal damage by down-regulating the ROS/autophagy/NLRP3 signal axis in fibrillar Aβ-activated microglia. [Abstract]

2023 Feb 15:1801:148206. PMID: 36539049
J Microbiol

NF-κB/ROS and ERK pathways regulate NLRP3 inflammasome activation in Listeria monocytogenes infected BV2 microglia cells. [Abstract]

2021 Aug;59(8):771-781. PMID: 34061343
PLoS One

Estrogen protects against liver damage in sepsis through inhibiting oxidative stress mediated activation of pyroptosis signaling pathway. [Abstract]

2020 Oct 1;15(10):e0239659. PMID: 33002070
Tissue Cell

Melatonin attenuates chronic obstructive pulmonary disease by suppressing NLRP3-mediated pyroptosis in alveolar macrophages. [Abstract]

2025 Dec 30:99:103305. PMID: 41500094
Tissue Cell

Ling-Gui-Zhu-Gan decoction inhibits cardiomyocyte pyroptosis via the NLRP3/Caspase-1 signaling pathway. [Abstract]

2024 Dec:91:102588. PMID: 39442311
J Neuroimmunol

A selective NLRP3 inflammasome inhibitor attenuates behavioral deficits and neuroinflammation in a mouse model of Parkinson's disease. [Abstract]

2021 May 15:354:577543. PMID: 33714750
Dig Dis Sci

Propofol Does Not Reduce Pyroptosis of Enterocytes and Intestinal Epithelial Injury After Lipopolysaccharide Challenge. [Abstract]

2018 Jan;63(1):81-91. PMID: 29063417

MCC950 purchased from MedChemExpress. Usage Cited in: Dig Dis Sci. 2018 Jan;63(1):81-91. [Abstract]

The expression of various molecules in pyroptotic and apoptotic pathways is detected by western blot. Representative bands from densitometric analysis in experimental groups are presented. M, MCC950 group (an inhibitor of NLRP3).
Immunol Invest

Astragalus Polysaccharide Promotes NLRP3+ Macrophages Polarization via Suppression of OGT in Hepatocellular Carcinoma. [Abstract]

2026 May;55(4):750-773. PMID: 41877503
Vet Sci

Porcine Epidemic Diarrhea Virus Infection of Porcine Intestinal Epithelial Cells Causes Mitochondrial DNA Release and the Activation of the NLRP3 Inflammasome to Mediate Interleukin-1β Secretion. [Abstract]

2024 Dec 12;11(12):643. PMID: 39728983
BMC Neurosci

Activation of autophagy inhibits the activation of NLRP3 inflammasome and alleviates sevoflurane-induced cognitive dysfunction in elderly rats. [Abstract]

2023 Jan 28;24(1):9. PMID: 36709248
BMC Cardiovasc Disord

Sodium tanshinone IIA sulfonate protects vascular relaxation in ApoE-knockout mice by inhibiting the SYK-NLRP3 inflammasome-MMP2/9 pathway. [Abstract]

2024 Jul 12;24(1):354. PMID: 38992615
BMC Cardiovasc Disord

Effect of NLRP3 gene knockdown on pyroptosis and ferroptosis in diabetic cardiomyopathy injury. [Abstract]

2024 Jul 10;24(1):351. PMID: 38987672
Immunobiology

The involvement of oxidative stress and the TLR4/NF-κB/NLRP3 pathway in acute lung injury induced by high-altitude hypoxia. [Abstract]

2024 May 17;229(3):152809. PMID: 38788361
BMC Cardiovasc Disord

Sodium tanshinone IIA sulfonate ameliorates neointima by protecting endothelial progenitor cells in diabetic mice. [Abstract]

2023 Sep 11;23(1):446. PMID: 37697234
Exp Ther Med

A20 affects macrophage polarization through the NLRP3 inflammasome signaling pathway and promotes breast cancer progression. [Abstract]

2023 Feb 15;25(4):147. PMID: 36911385
Exp Ther Med

Dexmedetomidine alleviates inflammation in neuropathic pain by suppressing NLRP3 via Nrf2 activation. [Abstract]

2021 Oct;22(4):1046. PMID: 34434260
Biochem Biophys Res Commun

Human cytomegalovirus protein US18 promotes NLRP3 inflammasome activation. [Abstract]

2025 May 28:775:152110. PMID: 40450990
Oncol Lett

Ursolic acid inhibits the invasiveness of A498 cells via NLRP3 inflammasome activation. [Abstract]

2020 Nov;20(5):170. PMID: 32934737
Biochem Biophys Res Commun

NLRP3 inhibition improves heart function in GPER knockout mice. [Abstract]

2019 Jun 30;514(3):998-1003. PMID: 31092335
Arch Oral Biol

Ginsenoside Rg1 alleviates lipopolysaccharide-induced pyroptosis in human periodontal ligament cells via inhibiting Drp1-mediated mitochondrial fission. [Abstract]

2023 Mar:147:105632. PMID: 36736069
Arch Oral Biol

Targeting the Nod-like receptor protein 3 Inflammasome with inhibitor MCC950 rescues lipopolysaccharide-induced inhibition of osteogenesis in Human periodontal ligament cells. [Abstract]

2021 Nov:131:105269. PMID: 34601319
Anat Rec

Resibufogenin suppresses growth and metastasis through inducing caspase-1-dependent pyroptosis via ROS-mediated NF-κB suppression in non-small cell lung cancer. [Abstract]

2021 Feb;304(2):302-312. PMID: 32396707
J Med Microbiol

E. coli Nissle 1917 improves gut microbiota composition and serum metabolites to counteract atherosclerosis via the homocitrulline/Caspase 1/NLRP3/GSDMD axis. [Abstract]

2024 Dec 26:318:151642. PMID: 39742694
Microbiol Immunol

Human Cytomegalovirus infection activates NLRP3 inflammasome by releasing mtDNA into cytosol in human THP-1 cells. [Abstract]

2023 Jun;67(6):303-313. PMID: 36932814
Cytotechnology

Panax notoginseng-Bletilla striata ameliorates reflux esophagitis by modulating NLRP3 inflammasomes and p38 MAPK pathway. [Abstract]

2026 Feb;78(1):3. PMID: 41280658
Mol Cell Toxicol

2025 Dec 8.
Biosci Biotechnol Biochem

Mito-tempo alleviates ox-LDL-provoked foam cell formation by regulating Nrf2/NLRP3 signaling. [Abstract]

2024 May 8:zbae058. PMID: 38719485
Res Sq

2026 Mar 11.
bioRxiv

2026 Mar 26.
Npj Viruses

The soluble G protein of respiratory syncytial virus promotes viral dissemination via TLR2-mediated NLRP3 priming and pyroptosis. [Abstract]

2026 Jan 27;4(1):6. PMID: 41593203
SSRN

2025 Nov 5.
bioRxiv

Chronic sensing of host-derived lipids is an all-in-one signal that primes and activates NLRP3. [Abstract]

2025 Oct 30:2025.10.29.685328. PMID: 41279623
Res Sq

2025 Oct 14.
SSRN

2025 Aug 7.
bioRxiv

2025 Aug 16.
SSRN

2025 Jul 16.
SSRN

2025 Jan 23.
SSRN

2025 Mar 11.
SSRN

2025 Jan 24.
Research Square Preprint

2024 Aug 26.
Research Square Preprint

2024 Mar 15.
SSRN

2023 Dec 5.
Environ Sci Pollut Res Int

Filamin A facilitates NLRP3 inflammasome activation during arsenic-induced nonalcoholic steatohepatitis. [Abstract]

2023 Oct;30(49):107703-107715. PMID: 37740811
Research Square Preprint

2023 Aug 7.
Research Square Preprint

2023 Jul 19.
bioRxiv

2023 Jul 7.
Research Square Preprint

2023 May 30.
bioRxiv

2023 Jun 25.
Research Square Preprint

2023 May 24.
Oxid Med Cell Longev

Curcumin Ameliorates Age-Induced Tight Junction Impaired in Porcine Sertoli Cells by Inactivating the NLRP3 Inflammasome through the AMPK/SIRT3/SOD2/mtROS Signaling Pathway. [Abstract]

2023 Feb 17:2023:1708251. PMID: 36846717
Research Square Print

2022 Sep 15.
Research Square Print

2022 Aug.
Research Square Print

2022 Aug.
Research Square Print

2022 Jun.
Research Square Preprint

2022 May.
Research Square Print

2022 May.
Research Square Preprint

2022 May.
Oxid Med Cell Longev

Inhibiting Microglia-Derived NLRP3 Alleviates Subependymal Edema and Cognitive Dysfunction in Posthemorrhagic Hydrocephalus after Intracerebral Hemorrhage via AMPK/Beclin-1 Pathway. [Abstract]

2022 May 17;2022:4177317. PMID: 35620574
Research Square Preprint

2022 Mar.
Oxid Med Cell Longev

HBO Alleviates Neural Stem Cell Pyroptosis via lncRNA-H19/miR-423-5p/NLRP3 Axis and Improves Neurogenesis after Oxygen Glucose Deprivation. [Abstract]

2022 Feb 7;2022:9030771. PMID: 35178162
bioRxiv

January 25, 2022.
Research Square Preprint

2022 Jan.
SSRN

8 Nov 2021.
Research Square Preprint

2021 Aug.
Research Square Preprint

2021 Aug.
Research Square Preprint

2021 Mar.
Research Square Preprint

2021 Feb.
Oxid Med Cell Longev

Resveratrol Confers Vascular Protection by Suppressing TLR4/Syk/NLRP3 Signaling in Oxidized Low-Density Lipoprotein-Activated Platelets. [Abstract]

2021 Feb 25:2021:8819231. PMID: 33728029
Research Square Preprint

2020 Nov.
Evid Based Complement Alternat Med

Bushen-Yizhi Formula Alleviates Neuroinflammation via Inhibiting NLRP3 Inflammasome Activation in a Mouse Model of Parkinson's Disease. [Abstract]

2018 Aug 26:2018:3571604. PMID: 30224927

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (123.62 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 9.52 mg/mL (23.54 mM; ultrasonic and adjust pH to 10 with 1 M NaOH)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.4723 mL

12.3616 mL

24.7231 mL

5 mM

0.4945 mL

2.4723 mL

4.9446 mL

10 mM

0.2472 mL

1.2362 mL

2.4723 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (6.18 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (6.18 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (6.18 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Protocol

Cell Assay^[1]

BMDM are seeded at 5×10⁵/mL or 1×10⁶/mL, HMDM at 5×10⁵/mL and PBMC at 2×10⁶/mL or 5×10⁶/mL in 96 well plates. The following day the overnight medium is replaced and cells are stimulated with 10 ng/mL LPS from Escherichia coli serotype EH100 (ra) TLRgrad for 3 h. Medium is removed and replaced with serum free medium (SFM) containing DMSO (1:1,000), MCC950 (0.001-10 µM), Parthenolide (10 µM) or Bayer cysteinyl leukotriene receptor antagonist 1-(5-carboxy-2{3-[4-(3-cyclohexylpropoxy)phenyl]propoxy}benzoyl)piperidine-4-carboxylic acid (40 µM) for 30 min. Cells are then stimulated with inflammasome activators: 5 mM adenosine 5’-triphosphate disodium salt hydrate (ATP) (1 h), 1 µg/mL Poly(deoxyadenylic-thymidylic) acid sodium salt (Poly dA:dT) transfected with Lipofectamine 200 (3-4 h), 200 µg/mL MSU (overnight) and 10 µM nigericin (1 h) or S. typhimurium UK-1 strain. Cells are also stimulated with 25 µg/mL Polyadenylic-polyuridylic acid (4 h). For non-canonical inflammasome activation cells are primed with 100 ng/mL Pam3CSK4 for 4 h, medium is removed and replaced with SFM containing DMSO or MCC950 and 2 µg/mL LPS is transfected using 0.25% FuGENE for 16 h. Supernatants are removed and analysed using ELISA kits. LDH release is measured using the CytoTox96 non-radioactive cytotoxicity assay^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Administration^[1]

Mice^[1]
C57BL/6 mice are immunized subcutaneously with 150 µg of MOG peptide 35-55 emulsified in CFA containing 4 mg/mL (0.4.mg/mouse) of heat-killed MTB. Mice are injected i.p. with 500 ng pertussis toxin (PT: kaketsuken) on days 0 and 2. MCC950 is administered i.p. to mice (10 mg/kg) at induction of the disease, day 0, 1 and 2 and every 2 days thereafter. Control mice are administered vehicle (PBS) at the same time points. Mice are observed for clinical signs of disease daily (unblinded). Disease severity is scored as follows: no clinical signs, 0; limp tail, 1; ataxic gait, 2; hind limb weakness, 3; hind limb paralysis, 4; and tetra paralysis, 5.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (281 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Coll RC, et al. A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases. Nat Med. 2015 Mar;21(3):248-55. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O / DMSO	1 mM	2.4723 mL	12.3616 mL	24.7231 mL	61.8078 mL
	5 mM	0.4945 mL	2.4723 mL	4.9446 mL	12.3616 mL
	10 mM	0.2472 mL	1.2362 mL	2.4723 mL	6.1808 mL
	15 mM	0.1648 mL	0.8241 mL	1.6482 mL	4.1205 mL
	20 mM	0.1236 mL	0.6181 mL	1.2362 mL	3.0904 mL
DMSO	25 mM	0.0989 mL	0.4945 mL	0.9889 mL	2.4723 mL
	30 mM	0.0824 mL	0.4121 mL	0.8241 mL	2.0603 mL
	40 mM	0.0618 mL	0.3090 mL	0.6181 mL	1.5452 mL
	50 mM	0.0494 mL	0.2472 mL	0.4945 mL	1.2362 mL
	60 mM	0.0412 mL	0.2060 mL	0.4121 mL	1.0301 mL
	80 mM	0.0309 mL	0.1545 mL	0.3090 mL	0.7726 mL
	100 mM	0.0247 mL	0.1236 mL	0.2472 mL	0.6181 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
Purity:
Quantity:

MCC950

Immunology/Inflammation Compound Library

NF-κB Signaling Compound Library

Antioxidant Compound Library

Oxygen Sensing Compound Library

Pyroptosis Compound Library

Antidepressant Compound Library

Human Metabolite Library

Heterocyclic Compound Library

Membrane Receptor-targeted Compound Library

Autoimmune Disease Compound Library

Highly Selective Inhibitors Library

Inflammasomes related Compound Library

Radioprotector Library

Bioactive Compound Library Max

Cell Death Inhibitor Library Mini

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Mass Spectrometry Human Metabolite Library

Pattern Recognition Receptors Library

Publications Citing Use of MedChemExpress (MCE) MCC950

All NOD-like Receptor (NLR) Isoforms

Biological Activity

Chemical Information

Publications (456)

Solvent & Solubility

Protocol

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

MCC950

Immunology/Inflammation Compound Library

NF-κB Signaling Compound Library

Antioxidant Compound Library

Oxygen Sensing Compound Library

Pyroptosis Compound Library

Antidepressant Compound Library

Human Metabolite Library

Heterocyclic Compound Library

Membrane Receptor-targeted Compound Library

Autoimmune Disease Compound Library

Highly Selective Inhibitors Library

Inflammasomes related Compound Library

Radioprotector Library

Bioactive Compound Library Max

Cell Death Inhibitor Library Mini

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Mass Spectrometry Human Metabolite Library

Pattern Recognition Receptors Library

Publications Citing Use of MedChemExpress (MCE) MCC950

All NOD-like Receptor (NLR) Isoforms

Biological Activity

Chemical Information

Publications (456)

Solvent & Solubility

Protocol

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

MCC950 Related Classifications

Cat. No.: HY-12815