36330-85-5
36330-85-5
Chemical Structure
Fenbufen
Synonym(s): CL-82204
- CAS No.: 36330-85-5
- Formula:C16H14O3
- Molecular Weight:254.28
IUPAC Name: 4-([1,1'-biphenyl]-4-yl)-4-oxobutanoic acid
InChIKey: ZPAKPRAICRBAOD-UHFFFAOYSA-N
SMILES: O=C(O)CCC(C1=CC=C(C2=CC=CC=C2)C=C1)=O
Biological Activity: Fenbufen (CL-82204) is an orally active non-steroidal anti-inflammatory drug (NSAID), with analgetic and antipyretic effects. Fenbufen has potent activity in a variety of animal model, including carageenin edema, UV erythema and adjuvant arthritis. Fenbufen has inhibitory activities against COX-1 and COX-2 with IC50s of 3.9 μM and 8.1 μM, respectively. Fenbufen is a caspases (caspase-1, 3, 4, 5, 9) inhibitor[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Fenbufen | 98.50% | Fenbufen (CL-82204) is an orally active non-steroidal anti-inflammatory drug (NSAID), with analgetic and antipyretic effects. Fenbufen has potent activity in a variety of animal model, including carageenin edema, UV erythema and adjuvant arthritis. Fenbufen has inhibitory activities against COX-1 and COX-2 with IC50s of 3.9 μM and 8.1 μM, respectively. Fenbufen is a caspases (caspase-1, 3, 4, 5, 9) inhibitor. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Fenbufen (Standard) | ≥98% | Fenbufen (Standard) is the analytical standard of Fenbufen. This product is intended for research and analytical applications. Fenbufen (CL-82204) is an orally active non-steroidal anti-inflammatory drug (NSAID), with analgetic and antipyretic effects. Fenbufen has potent activity in a variety of animal model, including carageenin edema, UV erythema and adjuvant arthritis. Fenbufen has inhibitory activities against COX-1 and COX-2 with IC50s of 3.9 μM and 8.1 μM, respectively. Fenbufen is a caspases (caspase-1, 3, 4, 5, 9) inhibitor. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Fenbufen-d9 | Fenbufen-d9 (CL-82204-d9) is the deuterium labeled Fenbufen. Fenbufen (CL-82204) is an orally active non-steroidal anti-inflammatory drug (NSAID), with antipyretic effects. Fenbufen has potent activity in a variety of animal model, including carageenin edema, UV erythema and adjuvant arthritis. Fenbufen has inhibitory activities against COX-1 and COX-2 with IC50s of 3.9 μM and 8.1 μM, respectively. Fenbufen is a caspases (caspase-1, 3, 4, 5, 9) inhibitor. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Fluenetil | Fluenetil (M2060) is a compound with insecticidal activity. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
ABD56 | ABD56 is a compound that induces osteoclast apoptosis and has the activity of inhibiting osteoclast formation and inducing apoptosis. ABD56 can inhibit osteoclast formation and induce apoptosis, and its mechanism is related to the inhibition of NFκB and ERK pathways. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Xenbucin | Xenbucin is an active compound. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
LBA-3 | LBA-3 is a selective, orally active inhibitor for sodium-coupled citrate transporter SLC13A5, with an IC50 of 67 nM. LBA-3 decreases levels of triglyceride and total cholesterol in oleic and palmitic acid (OPA)-stimulated AML12 cells, PCN-stimulated primary mouse hepatocytes and in mouse models, without detectable toxicity. LBA-3 is blood-brain barrier permeable. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
L-Biphenylalanine | 99.68% | L-Biphenylalanine is a phenylalanine derivative. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Felbinac | 99.94% | Felbinac is a metabolite of fenbufen, an orally active nonsteroidal anti-inflammatory agent and a cyclooxygenase (COX) inhibitor with an IC50 of 865.68 nM for COX1 and 976 nM for COX2. Felbinac reduces the production of prostaglandins by inhibiting COX to relieve pain, reduce inflammation and reduce fever. Felbinac can inhibit CHIKV viral activity. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
4,4'-Bibenzoic acid | 98.76% | 4,4'-Bibenzoic acid is a rigid monomer. 4,4'-Bibenzoic acid is used for the synthesis of copolymers. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
4,4'-Diacetylbiphenyl | 4,4'-Diacetylbiphenyl is a metal-organic framework (MOF). | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Biprofen | 99.72% | Biprofen is a biphenyl derivative (propionic acid derivative) non-steroidal anti-inflammatory agent with antipyretic and analgesic activities. Biprofen can be used for the research of inflammatory diseases and fever-related disorders. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
4-Phenylcinnamic acid | 4-Phenylcinnamic acid is a weak HDAC2 inhiibitor (IC50 > 5 μM). 4-Phenylcinnamic acid has weak cell growth inhibition against tumor cells. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. A E Sloboda, et al. The pharmacological properties of fenbufen. A review. Arzneimittelforschung. 1980;30(4A):716-21. [Content Brief]
- [2]. R G Child, et al. Fenbufen, a new anti-inflammatory analgesic: synthesis and structure-activity relationships of analogs, J Pharm Sci. 1977 Apr;66(4):466-76. [Content Brief]
- [3]. A E Sloboda, et al. The pharmacology of fenbufen, 3-(4-biphenylylcarbonyl)propionic acid, and 4-biphenylacetic acid, interesting antiinflammatory-analgesic agents. Inflammation. 1976 Dec;1(4):415-38. [Content Brief]
- [4]. Asif Husain, et al. Fenbufen based 3-[5-(substituted aryl)-1,3,4-oxadiazol-2-yl]-1-(biphenyl-4-yl)propan-1-ones as safer antiinflammatory and analgesic agents. Eur J Med Chem . 2009 Sep;44(9):3798-804. [Content Brief]
- [5]. Christina E Smith, et al. Non-steroidal Anti-inflammatory Drugs Are Caspase Inhibitors. Cell Chem Biol. 2017 Mar 16;24(3):281-292. [Content Brief]
