2. Membrane Transporter/Ion Channel
  3. Sodium Channel
  4. LBA-3

LBA-3 is a selective, orally active inhibitor for sodium-coupled citrate transporter SLC13A5, with an IC50 of 67 nM. LBA-3 decreases levels of triglyceride and total cholesterol in oleic and palmitic acid (OPA)-stimulated AML12 cells, PCN-stimulated primary mouse hepatocytes and in mouse models, without detectable toxicity. LBA-3 is blood-brain barrier permeable.

For research use only. We do not sell to patients.

LBA-3 Chemical Structure

LBA-3 Chemical Structure

CAS No. : 2918263-09-7

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LBA-3 Related Antibodies

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Description

LBA-3 is a selective, orally active inhibitor for sodium-coupled citrate transporter SLC13A5, with an IC50 of 67 nM. LBA-3 decreases levels of triglyceride and total cholesterol in oleic and palmitic acid (OPA)-stimulated AML12 cells, PCN-stimulated primary mouse hepatocytes and in mouse models, without detectable toxicity. LBA-3 is blood-brain barrier permeable[1].

In Vivo

LBA-3 (50 mg/kg, po, single dose) exhibits a pharmacokinetic profil in Sprague Dawley rats, with peak plasma concentration Cmax of 288 262.00 μg/L, AUC of 704 570.43 h/μg–1·L and an oral bioavailability of 48.67%[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

314.33

Formula

C18H18O5
CAS No.
SMILES

O=C(C(CCC1=CC=C(C=C1)C2=CC=CC=C2)(CC(O)=O)O)O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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LBA-3 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LBA-32918263-09-7LBA3LBA 3Sodium ChannelNa channelsNa+ channelshyperlipidemiaAML12sprague Dawley ratsC57BL/6J miceInhibitorinhibitorinhibit

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