Ac-YVAD-pNA
Based on 1 Customer Validation
Ac-YVAD-pNA is a specific Caspase-1 substrate. Ac-YVAD-pNA can be used to detect Caspase-1 activity. Caspase-1 is a key mediator of inflammatory processes.
For research use only. We do not sell to patients.
- Purity: 98.01%
- CAS No.: 149231-66-3
- Formula: C29H36N6O10
- Molecular Weight:628.63
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Storage:
Sealed storage, away from moisture and light.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Caspase Isoforms
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Biological Activity
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Caspase-1 |
Chemical Information
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CAS No. 149231-66-3
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Appearance Solid
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Molecular Weight 628.63
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Formula C29H36N6O10
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Color White to off-white
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Sequence
Ac-Tyr-Val-Ala-Asp-{pNA}
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Sequence Shortening
Ac-YVAD-{pNA}
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture and light
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : ≥ 250 mg/mL (397.69 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Pereira NA, et al. Some commonly used caspase substrates and inhibitors lack the specificity required to monitor individual caspase activity. Biochem Biophys Res Commun. 2008 Dec 19;377(3):873-7. [Content Brief]
[2]. Xin W, Wang Q, et al. A new mechanism of inhibition of IL-1β secretion by celastrol through the NLRP3 inflammasome pathway. Eur J Pharmacol. 2017 Nov 5;814:240-247. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.5908 mL | 7.9538 mL | 15.9076 mL | 39.7690 mL |
| 5 mM | 0.3182 mL | 1.5908 mL | 3.1815 mL | 7.9538 mL | |
| 10 mM | 0.1591 mL | 0.7954 mL | 1.5908 mL | 3.9769 mL | |
| 15 mM | 0.1061 mL | 0.5303 mL | 1.0605 mL | 2.6513 mL | |
| 20 mM | 0.0795 mL | 0.3977 mL | 0.7954 mL | 1.9885 mL | |
| 25 mM | 0.0636 mL | 0.3182 mL | 0.6363 mL | 1.5908 mL | |
| 30 mM | 0.0530 mL | 0.2651 mL | 0.5303 mL | 1.3256 mL | |
| 40 mM | 0.0398 mL | 0.1988 mL | 0.3977 mL | 0.9942 mL | |
| 50 mM | 0.0318 mL | 0.1591 mL | 0.3182 mL | 0.7954 mL | |
| 60 mM | 0.0265 mL | 0.1326 mL | 0.2651 mL | 0.6628 mL | |
| 80 mM | 0.0199 mL | 0.0994 mL | 0.1988 mL | 0.4971 mL | |
| 100 mM | 0.0159 mL | 0.0795 mL | 0.1591 mL | 0.3977 mL |
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