149231-66-3
149231-66-3
Chemical Structure
Ac-YVAD-pNA
- CAS No.: 149231-66-3
- Formula:C29H36N6O10
- Molecular Weight:628.63
InChIKey: YDPNOCSPPGFBPX-XNHCRPTKSA-N
SMILES: O=C(NC1=CC=C([N+]([O-])=O)C=C1)[C@H](CC(O)=O)NC([C@H](C)NC([C@H](C(C)C)NC([C@@H](NC(C)=O)CC2=CC=C(O)C=C2)=O)=O)=O
Biological Activity: Ac-YVAD-pNA is a specific Caspase-1 substrate. Ac-YVAD-pNA can be used to detect Caspase-1 activity. Caspase-1 is a key mediator of inflammatory processes[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Ac-YVAD-pNA | 98.01% | Ac-YVAD-pNA is a specific Caspase-1 substrate. Ac-YVAD-pNA can be used to detect Caspase-1 activity. Caspase-1 is a key mediator of inflammatory processes. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.90
HY-P2630Suc-YVAD-pNA -
Similarity Score 0.80
HY-P5974Z-YVAD-pNA -
Similarity Score 0.78
HY-P4491Suc-Leu-Leu-Val-Tyr-pNA -
Similarity Score 0.74
HY-P2717Ac-YVAD-AMC -
Similarity Score 0.73
HY-P10084Ac-VAD-pNA -
Similarity Score 0.71
HY-W713878Ac-VDVAD-pNA -
Similarity Score 0.70
HY-P11734Suc-AAPY-pNA -
Similarity Score 0.70
HY-P2377Ac-YVAD-AFC -
Similarity Score 0.70
HY-P10244Ac-YVAD-FMK -
Explore the MedChemAI to find more analogs
References
- [1]. Pereira NA, et al. Some commonly used caspase substrates and inhibitors lack the specificity required to monitor individual caspase activity. Biochem Biophys Res Commun. 2008 Dec 19;377(3):873-7. [Content Brief]
- [2]. Xin W, Wang Q, et al. A new mechanism of inhibition of IL-1β secretion by celastrol through the NLRP3 inflammasome pathway. Eur J Pharmacol. 2017 Nov 5;814:240-247. [Content Brief]
