Ac-YVAD-AFC
Based on 4 publication(s) in Google Scholar
Ac-YVAD-AFC is the the fluorometric peptide substrate of caspase-1, with λ excitation of 400 nm and λ emission of 505 nm.
For research use only. We do not sell to patients.
- Purity: 99.90%
- CAS No.: 219137-85-6
- Formula: C33H36F3N5O10
- Molecular Weight:719.66
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Storage:
Sealed storage, away from moisture and light, under nitrogen.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Ac-YVAD-AFC
More
Biological Activity
460
380
Chemical Information
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CAS No. 219137-85-6
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Appearance Solid
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Molecular Weight 719.66
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Formula C33H36F3N5O10
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Color White to off-white
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Sequence Shortening
Ac-YVAD-{AFC}
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture and light, under nitrogen
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
Publications (4)
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Journal Impact Factor
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Most Recent
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Food Chem
Transient autophagy inhibition strengthened postharvest tomato (Solanum lycopersicum) resistance against Botrytis cinerea through curtailing ROS-induced programmed cell death. [Abstract]2024 May 25:454:139811. PMID: 38820631 -
Int J Mol Sci
HERV-W Env Induces Neuron Pyroptosis via the NLRP3-CASP1-GSDMD Pathway in Recent-Onset Schizophrenia. [Abstract]2025 Jan 9;26(2):520. PMID: 39859234 -
Fish Shellfish Immunol
Paralichthys olivaceus GSDME-mediated pyroptosis is regulated by multiple caspases in different manners. [Abstract]2024 Nov 2:110002. PMID: 39491658 -
Genes (Basel)
Characterization of the Apoptotic and Antimicrobial Activities of Two Initiator Caspases of Sea Cucumber Apostichopus japonicus. [Abstract]2024 Apr 25;15(5):540. PMID: 38790170
Solvent & Solubility
DMSO : 100 mg/mL (138.95 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Furuoka M, et al. TNF-α Induces Caspase-1 Activation Independently of Simultaneously Induced NLRP3 in 3T3-L1 Cells. J Cell Physiol. 2016 Dec;231(12):2761-7. [Content Brief]
[2]. Guo RF, et al. Protective effects of anti-C5a in sepsis-induced thymocyte apoptosis. J Clin Invest. 2000 Nov;106(10):1271-80. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.3895 mL | 6.9477 mL | 13.8955 mL | 34.7386 mL |
| 5 mM | 0.2779 mL | 1.3895 mL | 2.7791 mL | 6.9477 mL | |
| 10 mM | 0.1390 mL | 0.6948 mL | 1.3895 mL | 3.4739 mL | |
| 15 mM | 0.0926 mL | 0.4632 mL | 0.9264 mL | 2.3159 mL | |
| 20 mM | 0.0695 mL | 0.3474 mL | 0.6948 mL | 1.7369 mL | |
| 25 mM | 0.0556 mL | 0.2779 mL | 0.5558 mL | 1.3895 mL | |
| 30 mM | 0.0463 mL | 0.2316 mL | 0.4632 mL | 1.1580 mL | |
| 40 mM | 0.0347 mL | 0.1737 mL | 0.3474 mL | 0.8685 mL | |
| 50 mM | 0.0278 mL | 0.1390 mL | 0.2779 mL | 0.6948 mL | |
| 60 mM | 0.0232 mL | 0.1158 mL | 0.2316 mL | 0.5790 mL | |
| 80 mM | 0.0174 mL | 0.0868 mL | 0.1737 mL | 0.4342 mL | |
| 100 mM | 0.0139 mL | 0.0695 mL | 0.1390 mL | 0.3474 mL |
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