219137-85-6
Chemical Structure
Ac-YVAD-AFC
- CAS No.: 219137-85-6
- Formula:C33H36F3N5O10
- Molecular Weight:719.66
IUPAC Name: (4S,7S,10S,13S)-4-(4-hydroxybenzyl)-7-isopropyl-10-methyl-2,5,8,11-tetraoxo-13-((2-oxo-4-(trifluoromethyl)-2H-chromen-7-yl)carbamoyl)-3,6,9,12-tetraazapentadecan-15-oic acid
InChIKey: GWKJISJKNKIJNP-DEQDFGQZSA-N
SMILES: FC(F)(C(C(C(O1)=C2)=CC=C2NC([C@H](CC(O)=O)NC([C@H](C)NC([C@H](C(C)C)NC([C@@H](NC(C)=O)CC(C=C3)=CC=C3O)=O)=O)=O)=O)=CC1=O)F
Biological Activity: Ac-YVAD-AFC is a specifically designed fluorescent Caspase-1 substrate. Ac-YVAD-AFC can be specifically cleaved by activated Caspase-1, thereby releasing free AFC fluorophore for detection. Ac-YVAD-AFC is a powerful tool for quantitative analysis of enzyme activity, for example, playing a key role in studying TNF-α-induced Caspase-1 activation in adipocyte lysates. Ac-YVAD-AFC is widely used in mechanistic studies of inflammasome signaling pathways and related diseases such as sepsis[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Ac-YVAD-AFC | 99.90% | Ac-YVAD-AFC is a specifically designed fluorescent Caspase-1 substrate. Ac-YVAD-AFC can be specifically cleaved by activated Caspase-1, thereby releasing free AFC fluorophore for detection. Ac-YVAD-AFC is a powerful tool for quantitative analysis of enzyme activity, for example, playing a key role in studying TNF-α-induced Caspase-1 activation in adipocyte lysates. Ac-YVAD-AFC is widely used in mechanistic studies of inflammasome signaling pathways and related diseases such as sepsis. | ||||||||||||||||||||
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Similarity Score 0.89
HY-P2717Ac-YVAD-AMC -
Similarity Score 0.83
HY-P10317Suc-YVAD-AMC -
Similarity Score 0.83
HY-P4429Z-YVAD-AFC -
Similarity Score 0.81
HY-P10142Ac-YEVD-AMC -
Similarity Score 0.76
HY-P2615Ac-VDVAD-AFC -
Similarity Score 0.75
HY-P3115Ac-LEVD-AFC -
Similarity Score 0.74
HY-P5983Ac-VEID-AFC -
Similarity Score 0.74
HY-P1005Ac-DEVD-AFC -
Similarity Score 0.73
HY-DY1060Suc-Leu-Leu-Val-Tyr-AMC (solution) -
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References
- [1]. Guo RF, et al. Protective effects of anti-C5a in sepsis-induced thymocyte apoptosis. J Clin Invest. 2000;106(10):1271-1280. [Content Brief]
- [2]. Furuoka M, et al. TNF‐α induces caspase‐1 activation independently of simultaneously induced NLRP3 in 3t3‐L1 cells[J]. Journal of Cellular Physiology, 2016, 231(12): 2761-2767.
