Tranilast sodium
Based on 9 publication(s) in Google Scholar
Tranilast sodium (MK-341 sodium) acts as an anti-atopic agent. Tranilast suppresses production of prostaglandin D2 (PGD2, IC50= 0.1 mM). Tranilast sodium exhibits anti-inflammatory and immunomodulatory effects. Tranilast sodium antagonizes angiotensin II and inhibits its biological effects in vascular smooth muscle cells.
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- Purity: 99.48%
- CAS No.: 104931-56-8
- 화학식: C18H16NNaO5
- 분자량:349.31
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보관:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Tranilast sodium
More- Cell Metab. 2022 Mar 1;34(3):424-440.e7. [Abstract]
- Autophagy. 2021 Nov;17(11):3592-3606. [Abstract]
- Mol Cell. 2023 Jan 14;S1097-2765(22)01217-5. [Abstract]
- Cell Death Differ. 2026 May 31. [Abstract]
- Mol Biomed. 2025 Nov 13;6(1):108. [Abstract]
- Cell Death Dis. 2025 Aug 6;16(1):592. [Abstract]
- Pharmacol Res. 2017 Nov;125(Pt B):150-160. [Abstract]
- Cell Calcium. 2024 Jan:117:102840. [Abstract]
- J Interferon Cytokine Res. 2021 Mar;41(3):102-110. [Abstract]
Customer Validation & Images
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Bio/Physico-chemical Assay
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Bio/Physico-chemical Assay
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Cell Imaging/Staining
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WB
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Bio/Physico-chemical Assay
All Angiotensin Receptor Isoforms
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Biological Activity
제품 설명
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Angiotensin II |
DP2 0.1 mM (IC50) |
In Vitro
Tranilast exhibits significant immunomodulatory activity inhibiting Endotoxin-induced prostaglandin E2 (PGE2; IC50=~1-20 μM), thromboxane B2 (IC50=~10-50 μM), (TGF-β1; IC50=~100-200 μM), and IL-8 (IC50=~100 μM) formation. A23187-induced monocyte leukotriene C4 or PGE2 formation is inhibited by Tranilast at IC50s of 10-40 μM and 2-20 μM, respectively[3].
Tranilast (10-200 μM) exhibits the anti-proliferative effect in a dose-dependent manner in both MCF-7 and MDA-MB-231 cell lines. Tranilast also (10-200μM) enhances the anti-tumor effects of Tamoxifen (1-20 μM) on human breast cancer cells in vitro[4].
Tranilast (12.5, 25, 50, 100 μg/mL; 72 hours) inhibits proliferation of HDMECs[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7 and MDA-MB-231 cells
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Concentration:10, 20, 50, 100, and 200 μM
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Incubation Time:48 hours
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Result:Anti-proliferative effect in a dose-dependent manner in both cell lines.
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Cell Line:Human dermal microvascular endothelial cells (HDMECs)
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Concentration:12.5, 25, 50, 100 μg/mL
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Incubation Time:72 hours
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Result:IC50 value was 44.3 μg/mL (136 μM).
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Nine-week-old male C57BL/6 mice[5]
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Dosage:300 mg/kg
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Administration:Administered orally twice a day for 3 days
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Result:Suppressed the VEGF-induced angiogenesis in matrigel; 58% of significant suppression was observed at a dose of 300 mg/kg.
The ED50 value and 95% confidence limits were 165 mg/kg and 162±169 mg/kg, respectively.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
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| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 104931-56-8
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Appearance Solid
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분자량 349.31
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화학식 C18H16NNaO5
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Color White to off-white
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SMILES
O=C([O-])C1=CC=CC=C1NC(/C=C/C2=CC=C(OC)C(OC)=C2)=O.[Na+]
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Synonyms
MK-341 sodium; SB 252218 sodium
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선적
Room temperature in continental US; may vary elsewhere.
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보관
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (9)
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Journal Impact Factor
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Most Recent
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Cell Metab
Imatinib and methazolamide ameliorate COVID-19-induced metabolic complications via elevating ACE2 enzymatic activity and inhibiting viral entry. [Abstract]2022 Mar 1;34(3):424-440.e7. PMID: 35150639 -
Autophagy
Cannabidiol inhibits human glioma by induction of lethal mitophagy through activating TRPV4. [Abstract]2021 Nov;17(11):3592-3606. PMID: 33629929 -
Mol Cell
Cytosolic DNA sensing by cGAS/STING promotes TRPV2-mediated Ca2+ release to protect stressed replication forks. [Abstract]2023 Jan 14;S1097-2765(22)01217-5. PMID: 36696898
Tranilast sodium purchased from MedChemExpress. Usage Cited in: Mol Cell. 2023 Jan 14;S1097-2765(22)01217-5. [Abstract]
Tranilast treatment (50 μM) on HU-induced [Ca2+]i elevation in S phase-synchronized HeLa cells treated with HU (2 mM, 4 h).
Tranilast sodium purchased from MedChemExpress. Usage Cited in: Mol Cell. 2023 Jan 14;S1097-2765(22)01217-5. [Abstract]
Tranilast treatment (50 μM) on the ER release of Ca2+ in S phase-synchronized HeLa cells treated with HU (2 mM, 4 h).
Tranilast sodium purchased from MedChemExpress. Usage Cited in: Mol Cell. 2023 Jan 14;S1097-2765(22)01217-5. [Abstract]
Effects of Tranilast treatment (50 μM) on T172-phosphorylation of AMPKα in HeLa cells treated with HU (2 mM, 4 h). γH2AX IF signal marks the cells with replication stress.
Tranilast sodium purchased from MedChemExpress. Usage Cited in: Mol Cell. 2023 Jan 14;S1097-2765(22)01217-5. [Abstract]
Effects of Tranilast treatment (50 μM) on S746-phosphorylation of Exo1-GFP in HeLa cells treated with HU (2 mM) for 4 h.
Tranilast sodium purchased from MedChemExpress. Usage Cited in: Mol Cell. 2023 Jan 14;S1097-2765(22)01217-5. [Abstract]
Effects of Tranilast on [Ca2+]i. in HeLa cells transfected with ssDNA or dsDNA fragments (2 μg/ml). Cells were imaged 6 h after transfection and Tranilast (50 μM) or DMSO was added 4 h before imaging.
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Cell Death Differ
ALKBH5 aggravates scarring after glaucoma surgery via m6A-YTHDF2-mediated NLRP3 mRNA stabilization. [Abstract]2026 May 31. PMID: 42218253 -
Mol Biomed
ML345 is a potent and selective NLRP3 inflammasome inhibitor with anti-inflammatory activity. [Abstract]2025 Nov 13;6(1):108. PMID: 41231359 -
Cell Death Dis
TGF-β1-mediated downregulation of L1CAM in pancreatic ductal adenocarcinoma drives upregulation of collagen 17A1 and MMP2, facilitating tumor invasiveness and metastasis. [Abstract]2025 Aug 6;16(1):592. PMID: 40770187 -
Pharmacol Res
Sinomenine-induced histamine release-like anaphylactoid reactions are blocked by tranilast via inhibiting NF-κB signaling. [Abstract]2017 Nov;125(Pt B):150-160. PMID: 28867637
Tranilast sodium purchased from MedChemExpress. Usage Cited in: Pharmacol Res. 2017 Nov;125(Pt B):150-160. [Abstract]
The IL-33 production in different treatment groups is determined in rat skin by immunohistochemistry assay.
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Cell Calcium
TRPV2 inhibitor tranilast prevents atrial fibrillation in rat models of pulmonary hypertension. [Abstract]2024 Jan:117:102840. PMID: 38160478 -
J Interferon Cytokine Res
Effects of Tranilast on Inflammasome and Macrophage Phenotype in a Mouse Model of Myocardial Infarction. [Abstract]2021 Mar;41(3):102-110. PMID: 33750216
용액&용해도
In Vitro:
DMSO : 50 mg/mL (143.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (280 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. K Ikai , et al. Inhibitory Effect of Tranilast on Prostaglandin D Synthetase. Biochem Pharmacol. 1989 Aug 15;38(16):2673-6. [Content Brief]
[2]. K Miyazawa , et al. Tranilast Antagonizes Angiotensin II and Inhibits Its Biological Effects in Vascular Smooth Muscle Cells. Atherosclerosis. 1996 Apr 5;121(2):167-73. [Content Brief]
[3]. E A Capper, et al. Modulation of Human Monocyte Activities by Tranilast, SB 252218, a Compound Demonstrating Efficacy in Restenosis. J Pharmacol Exp Ther. 2000 Dec;295(3):1061-9. [Content Brief]
[4]. Sara Darakhshan, et al. Tranilast Enhances the Anti-Tumor Effects of Tamoxifen on Human Breast Cancer Cells in Vitro. J Biomed Sci. 2013 Oct 21;20(1):76. [Content Brief]
[5]. M Isaji , et al. Tranilast Inhibits the Proliferation, Chemotaxis and Tube Formation of Human Microvascular Endothelial Cells in Vitro and Angiogenesis in Vivo. Br J Pharmacol. 1997 Nov;122(6):1061-6. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.8628 mL | 14.3139 mL | 28.6279 mL | 71.5697 mL |
| 5 mM | 0.5726 mL | 2.8628 mL | 5.7256 mL | 14.3139 mL | |
| 10 mM | 0.2863 mL | 1.4314 mL | 2.8628 mL | 7.1570 mL | |
| 15 mM | 0.1909 mL | 0.9543 mL | 1.9085 mL | 4.7713 mL | |
| 20 mM | 0.1431 mL | 0.7157 mL | 1.4314 mL | 3.5785 mL | |
| 25 mM | 0.1145 mL | 0.5726 mL | 1.1451 mL | 2.8628 mL | |
| 30 mM | 0.0954 mL | 0.4771 mL | 0.9543 mL | 2.3857 mL | |
| 40 mM | 0.0716 mL | 0.3578 mL | 0.7157 mL | 1.7892 mL | |
| 50 mM | 0.0573 mL | 0.2863 mL | 0.5726 mL | 1.4314 mL | |
| 60 mM | 0.0477 mL | 0.2386 mL | 0.4771 mL | 1.1928 mL | |
| 80 mM | 0.0358 mL | 0.1789 mL | 0.3578 mL | 0.8946 mL | |
| 100 mM | 0.0286 mL | 0.1431 mL | 0.2863 mL | 0.7157 mL |
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