1. GPCR/G Protein
  2. Prostaglandin Receptor
    Angiotensin Receptor
  3. Tranilast sodium

Tranilast sodium (Synonyms: MK-341 sodium; SB 252218 sodium)

Cat. No.: HY-B0195A
Handling Instructions

Tranilast sodium (MK-341 sodium) acts as an anti-atopic agent. Tranilast suppresses production of prostaglandin D2 (PGD2, IC50= 0.1 mM). Tranilast sodium exhibits anti-inflammatory and immunomodulatory effects. Tranilast sodium antagonizes angiotensin II and inhibits its biological effects in vascular smooth muscle cells.

For research use only. We do not sell to patients.

Tranilast sodium Chemical Structure

Tranilast sodium Chemical Structure

CAS No. : 104931-56-8

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Top Publications Citing Use of Products

    Tranilast sodium purchased from MCE. Usage Cited in: Pharmacol Res. 2017 Nov;125(Pt B):150-160.

    The IL-33 production in different treatment groups is determined in rat skin by immunohistochemistry assay.
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    Description

    Tranilast sodium (MK-341 sodium) acts as an anti-atopic agent. Tranilast suppresses production of prostaglandin D2 (PGD2, IC50= 0.1 mM). Tranilast sodium exhibits anti-inflammatory and immunomodulatory effects[1]. Tranilast sodium antagonizes angiotensin II and inhibits its biological effects in vascular smooth muscle cells[2].

    IC50 & Target

    PGD2

    0.1 mM (IC50)

    Angiotensin II

     

    In Vitro

    Tranilast exhibits significant immunomodulatory activity inhibiting Endotoxin-induced prostaglandin E2 (PGE2; IC50=~1-20 μM), thromboxane B2 (IC50=~10-50 μM), (TGF-β1; IC50=~100-200 μM), and IL-8 (IC50=~100 μM) formation. A23187-induced monocyte leukotriene C4 or PGE2 formation is inhibited by Tranilast at IC50s of 10-40 μM and 2-20 μM, respectively[3].
    Tranilast (10-200 μM) exhibits the anti-proliferative effect in a dose-dependent manner in both MCF-7 and MDA-MB-231 cell lines. Tranilast also (10-200μM) enhances the anti-tumor effects of Tamoxifen (1-20 μM) on human breast cancer cells in vitro[4].
    Tranilast (12.5, 25, 50, 100 μg/mL; 72 hours) inhibits proliferation of HDMECs[5].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Cell Proliferation Assay[4]

    Cell Line: MCF-7 and MDA-MB-231 cells
    Concentration: 10, 20, 50, 100, and 200 μM
    Incubation Time: 48 hours
    Result: Anti-proliferative effect in a dose-dependent manner in both cell lines.

    Cell Proliferation Assay[5]

    Cell Line: Human dermal microvascular endothelial cells (HDMECs)
    Concentration: 12.5, 25, 50, 100 μg/mL
    Incubation Time: 72 hours
    Result: IC50 value was 44.3 μg/mL (136 μM).
    In Vivo

    Tranilast (300 mg/kg; administered orally twice a day for 3 days) dose-dependently suppresses angiogenesis in mice[5].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Nine-week-old male C57BL/6 mice[5]
    Dosage: 300 mg/kg
    Administration: Administered orally twice a day for 3 days
    Result: Suppressed the VEGF-induced angiogenesis in matrigel; 58% of significant suppression was observed at a dose of 300 mg/kg.
    The ED50 value and 95% confidence limits were 165 mg/kg and 162±169 mg/kg, respectively.
    Clinical Trial
    Molecular Weight

    349.31

    Formula

    C₁₈H₁₆NNaO₅

    CAS No.
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    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.

    References
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    Tranilast sodium
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    HY-B0195A
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