104931-56-8
104931-56-8
Chemical Structure
Tranilast sodium
Synonym(s): MK-341 sodium; SB 252218 sodium
- CAS No.: 104931-56-8
- Formula:C18H16NNaO5
- Molecular Weight:349.31
IUPAC Name: sodium (E)-2-(3-(3,4-dimethoxyphenyl)acrylamido)benzoate
InChIKey: KZGHWWBBHZLTTA-VRTOBVRTSA-M
SMILES: O=C([O-])C1=CC=CC=C1NC(/C=C/C2=CC=C(OC)C(OC)=C2)=O.[Na+]
Biological Activity: Tranilast sodium (MK-341 sodium) acts as an anti-atopic agent. Tranilast suppresses production of prostaglandin D2 (PGD2, IC50= 0.1 mM). Tranilast sodium exhibits anti-inflammatory and immunomodulatory effects[1]. Tranilast sodium antagonizes angiotensin II and inhibits its biological effects in vascular smooth muscle cells[2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Tranilast sodium | 99.48% | Tranilast sodium (MK-341 sodium) acts as an anti-atopic agent. Tranilast suppresses production of prostaglandin D2 (PGD2, IC50= 0.1 mM). Tranilast sodium exhibits anti-inflammatory and immunomodulatory effects. Tranilast sodium antagonizes angiotensin II and inhibits its biological effects in vascular smooth muscle cells. | ||||||||||||||||||||
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References
- [1]. K Ikai , et al. Inhibitory Effect of Tranilast on Prostaglandin D Synthetase. Biochem Pharmacol. 1989 Aug 15;38(16):2673-6. [Content Brief]
- [2]. K Miyazawa , et al. Tranilast Antagonizes Angiotensin II and Inhibits Its Biological Effects in Vascular Smooth Muscle Cells. Atherosclerosis. 1996 Apr 5;121(2):167-73. [Content Brief]
