1. GPCR/G Protein
  2. Angiotensin Receptor
  3. Olmesartan

Olmesartan (Synonyms: RNH 6270; CS 088)

Cat. No.: HY-17004 Purity: 99.01%
Handling Instructions

Olmesartan is an angiotensin II receptor (AT1R) antagonist used to treat high blood pressure.

For research use only. We do not sell to patients.

Olmesartan Chemical Structure

Olmesartan Chemical Structure

CAS No. : 144689-24-7

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 79 In-stock
Estimated Time of Arrival: December 31
100 mg USD 72 In-stock
Estimated Time of Arrival: December 31
500 mg USD 210 In-stock
Estimated Time of Arrival: December 31
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Other Forms of Olmesartan:

Top Publications Citing Use of Products

    Olmesartan purchased from MCE. Usage Cited in: Biomed Pharmacother. 2017 Sep;93:429-434.

    Effect of Olmesartan and Bay11-7082 on the level of apoptotic proteins.The HeLa (4A) and Mcf-7 (4B) are treated with 5 mM Olmesartan and 25 μM of Bay11-7082 for 24 h. Western blot analysis is performed to determine the level of Bax,caspase-3, and IκB.
    • Biological Activity

    • Protocol

    • Technical Information

    • Purity & Documentation

    • References

    Description

    Olmesartan is an angiotensin II receptor (AT1R) antagonist used to treat high blood pressure.

    In Vivo

    Repeated dosing of olmesartan (1 mg/kg, 2 mg/kg, p.o.) dose-dependently decreases mean arterial blood pressure (MAP) in SHR without significant influence on body weight and food intake during 10 weeks[1]. Olmesartan (5 mg/kg/d, p.o.) and Hyd treatments lower systolic blood pressure to the same degree in mice. Olmesartan treatment inhibits cardiac hypertrophy, evaluated by echocardiography, heart weight, cross-sectional area of cardiomyocytes, and gene expression. Olmesartan treatment reverses decreased gene expressions of ACE2 and Mas receptor of Ren-Tg mice and inhibits enhanced NADPH oxidase (Nox)4 expression and reactive oxygen species[2].

    Clinical Trial
    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 55 mg/mL (123.18 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.2396 mL 11.1982 mL 22.3964 mL
    5 mM 0.4479 mL 2.2396 mL 4.4793 mL
    10 mM 0.2240 mL 1.1198 mL 2.2396 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Olmesartan is dissolved in sterile water containing 0.01% NaHCO3 and 0.01% KHCO3 and administered at a dose of 15 mg/L (equivalent to 3 mg/kg BW) in drinking water[3].

    *All of the co-solvents are provided by MCE.
    References
    Animal Administration
    [1]

    Seven week-old male spontaneously hypertensive rats (SHR) are divided into five groups and fed a high fat diet (HFD) (60% kcal as fat) ad libitum. SHR are treated with vehicle (1% tragacanth gum solution), telmisartan (1 mg/kg), telmisartan (2 mg/kg), olmesartan (1 mg/kg) or olmesartan (2 mg/kg) once daily by gastric gavage. After more than 4 weeks-treatment, mean arterial blood pressure is measured for 24 h under a conscious state.

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    References
    Molecular Weight

    446.50

    Formula

    C₂₄H₂₆N₆O₃

    CAS No.

    144689-24-7

    SMILES

    O=C(O)C1=C(N=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NN=NN4)CCC)C(O)(C)C

    Shipping

    Room temperature in continental US; may vary elsewhere

    Purity: 99.01%

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    • Dilution Calculator

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

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    Inquiry Information

    Product Name:
    Olmesartan
    Cat. No.:
    HY-17004
    Quantity:

    Olmesartan

    Cat. No.: HY-17004