1. GPCR/G Protein
  2. Angiotensin Receptor
  3. Olmesartan

Olmesartan (Synonyms: RNH-6270)

Cat. No.: HY-17004 Purity: 99.01%
Handling Instructions

Olmesartan (RNH-6270) is an angiotensin II receptor (AT1R) antagonist used to treat high blood pressure.

For research use only. We do not sell to patients.

Olmesartan Chemical Structure

Olmesartan Chemical Structure

CAS No. : 144689-24-7

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10 mM * 1 mL in DMSO USD 79 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 8 publication(s) in Google Scholar

Other Forms of Olmesartan:

Top Publications Citing Use of Products

    Olmesartan purchased from MCE. Usage Cited in: Biomed Pharmacother. 2017 Sep;93:429-434.

    Effect of Olmesartan and Bay11-7082 on the level of apoptotic proteins.The HeLa (4A) and Mcf-7 (4B) are treated with 5 mM Olmesartan and 25 μM of Bay11-7082 for 24 h. Western blot analysis is performed to determine the level of Bax,caspase-3, and IκB.
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    Description

    Olmesartan (RNH-6270) is an angiotensin II receptor (AT1R) antagonist used to treat high blood pressure[1][2].

    In Vitro

    Olmesartan (0.7-5 mM; 24, 48 and 72 h) inhibits the growth of HeLa cells as a concentration- and time-dependent mode[3].

    Cell Viability Assay[3]

    Cell Line: Human cervical cancer cell line (HeLa)
    Concentration: 0.7- 5 mM
    Incubation Time: 24, 48 and 72 h
    Result: IC50s against HeLa cell line are 4.685 and 1.651 mM for 48 and 72 h, respectively.
    In Vivo

    Repeated dosing of olmesartan (1 mg/kg, 2 mg/kg, p.o.) dose-dependently decreases mean arterial blood pressure (MAP) in SHR without significant influence on body weight and food intake during 10 weeks[1]. Olmesartan (5 mg/kg/d, p.o.) and Hyd treatments lower systolic blood pressure to the same degree in mice. Olmesartan treatment inhibits cardiac hypertrophy, evaluated by echocardiography, heart weight, cross-sectional area of cardiomyocytes, and gene expression. Olmesartan treatment reverses decreased gene expressions of ACE2 and Mas receptor of Ren-Tg mice and inhibits enhanced NADPH oxidase (Nox)4 expression and reactive oxygen species[2].

    Clinical Trial
    Molecular Weight

    446.50

    Formula

    C₂₄H₂₆N₆O₃

    CAS No.

    144689-24-7

    SMILES

    O=C(O)C1=C(N=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NN=NN4)CCC)C(O)(C)C

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 50 mg/mL (111.98 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.2396 mL 11.1982 mL 22.3964 mL
    5 mM 0.4479 mL 2.2396 mL 4.4793 mL
    10 mM 0.2240 mL 1.1198 mL 2.2396 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (5.60 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (5.60 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (5.60 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References
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    Keywords:

    OlmesartanRNH-6270RNH6270RNH 6270Angiotensin ReceptorInhibitorinhibitorinhibit

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    Product name:
    Olmesartan
    Cat. No.:
    HY-17004
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