1. GPCR/G Protein
  2. Angiotensin Receptor
  3. CGP-42112

CGP-42112 (Synonyms: CGP42112A)

Cat. No.: HY-12405 Purity: 98.82%
Handling Instructions

CGP-42112(CGP-42112A) is a potent Angiotensin-II subtype 2 receptor(AT2 R) agonist.

For research use only. We do not sell to patients.

CGP-42112 Chemical Structure

CGP-42112 Chemical Structure

CAS No. : 127060-75-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 1238 In-stock
Estimated Time of Arrival: December 31
1 mg USD 156 In-stock
Estimated Time of Arrival: December 31
5 mg USD 535 In-stock
Estimated Time of Arrival: December 31
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Description

CGP-42112(CGP-42112A) is a potent Angiotensin-II subtype 2 receptor(AT2 R) agonist. IC50 value: Target: AT2 R agonist in vitro: CGP42112 (>==1 nM) significantly inhibited cGMP production from the basal value. CGP42112 (>==1 nM) significantly inhibited TH-enzyme activity from the basal value. These inhibitory effects of CGP42112 on TH-enzyme activity and-cGMP production were abolished by PD123319 (AT(2)-R antagonist) while CV-11974 (AT(1)-R antagonist) was ineffective [1]. [125I]CGP 42112 bound selectively to the AT2 angiotensin II receptor subtype. [125I]CGP 42112 bound with higher affinity in the brain than in the adrenal. beta-Mercaptoethanol enhanced [125I]CGP 42112 binding in the brain, but did not alter its binding in the adrenal [2]. [125I]CGP 42112 bound with high affinity (Kd = 0.07-0.3 nM, depending on the area studied). [125I]CGP 42112 binding was selective for AT2 receptors, as determined by lack of competition with the AT1 ligand losartan, and competition by the AT2 ligands PD 123177 and unlabeled CGP 42112 and the non-selective peptides Ang II and angiotensin III (Ang III) [4]. in vivo: Intravenous infusions of CGP 42112 (0.1 and 1 mg kg-1 min-1) and PD 123319 (0.36 and 1 mg kg-1 min-1) shifted the upper limit of CBF autoregulation toward higher blood pressures without affecting baseline CBF [3].

Molecular Weight

1052.19

Formula

C₅₂H₆₉N₁₃O₁₁

CAS No.

127060-75-7

SMILES

CC[[email protected]](C)[[email protected]@H](C(O)=O)NC([[email protected]]1N(C([[email protected]](CC2=CNC=N2)NC([[email protected]](CCCCNC([[email protected]](CCCNC(N)=N)NC(OCC3=CC=CC=C3)=O)=O)NC([[email protected]](CC4=CC=C(C=C4)O)NC(C5=CC=CN=C5)=O)=O)=O)=O)CCC1)=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 350 mg/mL (332.64 mM)

*"≥" means soluble, but saturation unknown.

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Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9504 mL 4.7520 mL 9.5040 mL
5 mM 0.1901 mL 0.9504 mL 1.9008 mL
10 mM 0.0950 mL 0.4752 mL 0.9504 mL
*Please refer to the solubility information to select the appropriate solvent.
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CGP-42112
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