1. GPCR/G Protein
  2. Angiotensin Receptor
  3. PD 123319 ditrifluoroacetate

PD 123319 (ditrifluoroacetate) is a potent, selective AT2 angiotensin II receptor antagonist with IC50 of 34 nM.

For research use only. We do not sell to patients.

PD 123319 ditrifluoroacetate Chemical Structure

PD 123319 ditrifluoroacetate Chemical Structure

CAS No. : 136676-91-0

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Solid + Solvent
10 mM * 1 mL in Water
ready for reconstitution
USD 205 In-stock
Solution
10 mM * 1 mL in Water USD 205 In-stock
Solid
5 mg USD 127 In-stock
10 mg USD 158 In-stock
50 mg USD 528 In-stock
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Customer Review

Based on 9 publication(s) in Google Scholar

Other Forms of PD 123319 ditrifluoroacetate:

Top Publications Citing Use of Products

    PD 123319 ditrifluoroacetate purchased from MedChemExpress. Usage Cited in: FASEB J. 2018 Sep;32(9):5051-5062.  [Abstract]

    HUVECs are starved for 12 h, treated with 10 mg/mL (9.56 μM) of AngII with or without Losartan or PD123319 for 12 h, and are subsequently used for Western blot analysis.

    View All Angiotensin Receptor Isoform Specific Products:

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    PD 123319 (ditrifluoroacetate) is a potent, selective AT2 angiotensin II receptor antagonist with IC50 of 34 nM.

    IC50 & Target

    AT2 Receptor

     

    In Vitro

    PD 123319 is shown to discriminate between two subclasses of AII receptors in many different tissues.?125I-AII specifically label two classes of binding sites for AII in a membrane preparation of bovine adrenal glomerulosa cells. The first class (DuP-753 sensitive) represents approximately 85% of the total binding sites for AII and possesses a high affinity (IC50 of 92.9 nM) for DuP-753. PD-123319 does not have any effect on?125I-AII binding to this site. The second class of binding sites is more sensitive to PD-123319, with an IC50 of 6.9 nM, and has a much lower affinity for DuP-753 (IC50 around 10 microM)[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Molecular Weight

    736.66

    Formula

    C35H34F6N4O7

    CAS No.
    Appearance

    Solid

    Color

    White to yellow

    SMILES

    FC(F)(C(O)=O)F.FC(F)(C(O)=O)F.O=C([C@@H]1CC2=C(N=CN2CC3=CC=C(N(C)C)C(C)=C3)CN1C(C(C4=CC=CC=C4)C5=CC=CC=C5)=O)O

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    H2O : ≥ 36 mg/mL (48.87 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.3575 mL 6.7874 mL 13.5748 mL
    5 mM 0.2715 mL 1.3575 mL 2.7150 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

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    In Vivo:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 100 mg/mL (135.75 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.81%

    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 1.3575 mL 6.7874 mL 13.5748 mL 33.9370 mL
    5 mM 0.2715 mL 1.3575 mL 2.7150 mL 6.7874 mL
    10 mM 0.1357 mL 0.6787 mL 1.3575 mL 3.3937 mL
    15 mM 0.0905 mL 0.4525 mL 0.9050 mL 2.2625 mL
    20 mM 0.0679 mL 0.3394 mL 0.6787 mL 1.6968 mL
    25 mM 0.0543 mL 0.2715 mL 0.5430 mL 1.3575 mL
    30 mM 0.0452 mL 0.2262 mL 0.4525 mL 1.1312 mL
    40 mM 0.0339 mL 0.1697 mL 0.3394 mL 0.8484 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    PD 123319 ditrifluoroacetate Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    Product Name:
    PD 123319 ditrifluoroacetate
    Cat. No.:
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