1. GPCR/G Protein
  2. Angiotensin Receptor

PD 123319 ditrifluoroacetate 

Cat. No.: HY-10259A Purity: 99.76%
Handling Instructions

PD 123319 (ditrifluoroacetate) is a potent, selective AT2 angiotensin II receptor antagonist with IC50 of 34 nM.

For research use only. We do not sell to patients.

PD 123319 ditrifluoroacetate Chemical Structure

PD 123319 ditrifluoroacetate Chemical Structure

CAS No. : 136676-91-0

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10 mM * 1 mL in Water USD 186 In-stock
Estimated Time of Arrival: December 31
5 mg USD 115 In-stock
Estimated Time of Arrival: December 31
10 mg USD 144 In-stock
Estimated Time of Arrival: December 31
50 mg USD 480 In-stock
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Other Forms of PD 123319 ditrifluoroacetate:

Top Publications Citing Use of Products

    PD 123319 ditrifluoroacetate purchased from MCE. Usage Cited in: FASEB J. 2018 Sep;32(9):5051-5062.

    HUVECs are starved for 12 h, treated with 10 mg/mL (9.56 μM) of AngII with or without Losartan or PD123319 for 12 h, and are subsequently used for Western blot analysis.
    • Biological Activity

    • Technical Information

    • Purity & Documentation

    • References

    Description

    PD 123319 (ditrifluoroacetate) is a potent, selective AT2 angiotensin II receptor antagonist with IC50 of 34 nM.

    IC50 & Target

    IC50: 34 nM (AT2 Receptor)[1]

    In Vitro

    PD 123319 is shown to discriminate between two subclasses of AII receptors in many different tissues. 125I-AII specifically label two classes of binding sites for AII in a membrane preparation of bovine adrenal glomerulosa cells. The first class (DuP-753 sensitive) represents approximately 85% of the total binding sites for AII and possesses a high affinity (IC50 of 92.9 nM) for DuP-753. PD-123319 does not have any effect on 125I-AII binding to this site. The second class of binding sites is more sensitive to PD-123319, with an IC50 of 6.9 nM, and has a much lower affinity for DuP-753 (IC50 around 10 microM)[2]

    Solvent & Solubility
    In Vitro: 

    H2O : ≥ 36 mg/mL (48.87 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.3575 mL 6.7874 mL 13.5748 mL
    5 mM 0.2715 mL 1.3575 mL 2.7150 mL
    10 mM 0.1357 mL 0.6787 mL 1.3575 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References
    Molecular Weight

    736.66

    Formula

    C₃₅H₃₄F₆N₄O₇

    CAS No.

    136676-91-0

    SMILES

    FC(F)(C(O)=O)F.FC(F)(C(O)=O)F.O=C([[email protected]@H]1CC2=C(N=CN2CC3=CC=C(N(C)C)C(C)=C3)CN1C(C(C4=CC=CC=C4)C5=CC=CC=C5)=O)O

    Storage

    4°C, stored under nitrogen

    Shipping

    Room temperature in continental US; may vary elsewhere

    Purity: 99.76%

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    Product Name:
    PD 123319 ditrifluoroacetate
    Cat. No.:
    HY-10259A
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    PD 123319 ditrifluoroacetate

    Cat. No.: HY-10259A