PD 123319 ditrifluoroacetate
Based on 11 publication(s) in Google Scholar
PD 123319 (ditrifluoroacetate) is a potent, selective AT2 angiotensin II receptor antagonist with IC50 of 34 nM.
For research use only. We do not sell to patients.
- Purity: 99.34%
- CAS No.: 136676-91-0
- Formula: C35H34F6N4O7
- Molecular Weight:736.66
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) PD 123319 ditrifluoroacetate
More- Redox Biol. 2021 Oct:46:102115 [Abstract]
- J Exp Med. 2022 Mar 7;219(3):e20211001. [Abstract]
- Acta Pharmacol Sin. 2024 Jun;45(6):1201-1213. [Abstract]
- Clin Transl Med. 2025 Jun;15(6):e70361. [Abstract]
- Acta Physiol. 2026 Apr;242(4):e70200. [Abstract]
- Int Immunopharmacol. 2022 Sep:110:108921. [Abstract]
- FASEB J. 2019 May;33(5):6254-6268. [Abstract]
- FASEB J. 2018 Sep;32(9):5051-5062. [Abstract]
- Neurosci Lett. 2025 Aug 28:138369. [Abstract]
- Rep Biochem Mol Biol. 2021 Jul;10(2):314-326. [Abstract]
- SSRN. 13 Apr 2022.
Customer Validation & Images
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WB
All Angiotensin Receptor Isoforms
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Biological Activity
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AT2 Receptor |
PD 123319 is shown to discriminate between two subclasses of AII receptors in many different tissues.?125I-AII specifically label two classes of binding sites for AII in a membrane preparation of bovine adrenal glomerulosa cells. The first class (DuP-753 sensitive) represents approximately 85% of the total binding sites for AII and possesses a high affinity (IC50 of 92.9 nM) for DuP-753. PD-123319 does not have any effect on?125I-AII binding to this site. The second class of binding sites is more sensitive to PD-123319, with an IC50 of 6.9 nM, and has a much lower affinity for DuP-753 (IC50 around 10 microM)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 136676-91-0
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Appearance Solid
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Molecular Weight 736.66
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Formula C35H34F6N4O7
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Color White to yellow
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SMILES
FC(F)(C(O)=O)F.FC(F)(C(O)=O)F.O=C([C@@H]1CC2=C(N=CN2CC3=CC=C(N(C)C)C(C)=C3)CN1C(C(C4=CC=CC=C4)C5=CC=CC=C5)=O)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (11)
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Journal Impact Factor
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Most Recent
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Redox Biol
Gut microbiota dependent trimethylamine N-oxide aggravates angiotensin II-induced hypertension. [Abstract]2021 Oct:46:102115 PMID: 34474396 -
J Exp Med
Angiotensin II enhances group 2 innate lymphoid cell responses via AT1a during airway inflammation. [Abstract]2022 Mar 7;219(3):e20211001. PMID: 35044462 -
Acta Pharmacol Sin
Angiotensin II type-2 receptor signaling facilitates liver injury repair and regeneration via inactivation of Hippo pathway. [Abstract]2024 Jun;45(6):1201-1213. PMID: 38491160 -
Clin Transl Med
DDR2-mediated autophagy inhibition contributes to angiotensin II-induced adventitial remodeling. [Abstract]2025 Jun;15(6):e70361. PMID: 40468620 -
Acta Physiol
Angiotensin-(1-7) Alleviates Isoproterenol-Induced Cardiac Hypertrophy by Suppressing Autophagy and Apoptosis Through the Synergistic Action of Mas Receptor and Angiotensin II Type 2 Receptor. [Abstract]2026 Apr;242(4):e70200. PMID: 41886752 -
Int Immunopharmacol
Angiotensin II type 2 receptor pharmacological agonist, C21, reduces the inflammation and pain hypersensitivity in mice with joint inflammatory pain. [Abstract]2022 Sep:110:108921. PMID: 35724606 -
FASEB J
Transactivation domain of Krüppel-like factor 15 negatively regulates angiotensin II-induced adventitial inflammation and fibrosis. [Abstract]2019 May;33(5):6254-6268. PMID: 30776250 -
FASEB J
Angiotensin II increases angiogenesis by NF-κB-mediated transcriptional activation of angiogenic factor AGGF1. [Abstract]2018 Sep;32(9):5051-5062. PMID: 29641288
PD 123319 ditrifluoroacetate purchased from MedChemExpress. Usage Cited in: FASEB J. 2018 Sep;32(9):5051-5062. [Abstract]
HUVECs are starved for 12 h, treated with 10 mg/mL (9.56 μM) of AngII with or without Losartan or PD123319 for 12 h, and are subsequently used for Western blot analysis.
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Neurosci Lett
A novel angiotensin II type 2 receptor antagonist TDI05 alleviates the peripheral neuropathic pain. [Abstract]2025 Aug 28:138369. PMID: 40885515 -
Rep Biochem Mol Biol
Signaling Pathway in the Osmotic Resistance Induced by Angiotensin II AT2 Receptor Activation in Human Erythrocytes. [Abstract]2021 Jul;10(2):314-326. PMID: 34604421 -
Solvent & Solubility
H2O : ≥ 36 mg/mL (48.87 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (135.75 mM); Clear solution; Need ultrasonic
Purity & Documentation
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Data Sheet (282 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Blankley CJ, et al. Synthesis and structure-activity relationships of a novel series of non-peptide angiotensin II receptor binding inhibitors specific for the AT2 subtype. J Med Chem. 1991 Nov;34(11):3248-60. [Content Brief]
[2]. Boulay G, et al. Modulation of angiotensin II binding affinity by allosteric interaction of polyvinyl sulfate with an intracellular domain of the DuP-753-sensitive angiotensin II receptor of bovine adrenal glomerulosa. Mol Pharmacol. 1992 Apr;41(4):809-15 [Content Brief]
[3]. Estrup TM, et al. No effect of angiotensin II AT(2)-receptor antagonist PD 123319 on cerebral blood flow autoregulation. J Renin Angiotensin Aldosterone Syst. 2001 Sep;2(3):188-92. [Content Brief]
[4]. Brillante DG, et al. Effects of intravenous PD 123319 on haemodynamic and arterial stiffness indices in healthy volunteers. J Renin Angiotensin Aldosterone Syst. 2005 Sep;6(2):102-6. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.3575 mL | 6.7874 mL | 13.5748 mL | 33.9370 mL |
| 5 mM | 0.2715 mL | 1.3575 mL | 2.7150 mL | 6.7874 mL | |
| 10 mM | 0.1357 mL | 0.6787 mL | 1.3575 mL | 3.3937 mL | |
| 15 mM | 0.0905 mL | 0.4525 mL | 0.9050 mL | 2.2625 mL | |
| 20 mM | 0.0679 mL | 0.3394 mL | 0.6787 mL | 1.6968 mL | |
| 25 mM | 0.0543 mL | 0.2715 mL | 0.5430 mL | 1.3575 mL | |
| 30 mM | 0.0452 mL | 0.2262 mL | 0.4525 mL | 1.1312 mL | |
| 40 mM | 0.0339 mL | 0.1697 mL | 0.3394 mL | 0.8484 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
PD 123319 ditrifluoroacetate Related Classifications
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