1. GPCR/G Protein
  2. Angiotensin Receptor
  3. PD 123319

PD 123319 (Synonyms: (S)-(+)-PD 123319)

Cat. No.: HY-10259
Handling Instructions

PD 123319 (ditrifluoroacetate) is a potent, selective AT2 angiotensin II receptor antagonist with IC50 of 34 nM.

For research use only. We do not sell to patients.

PD 123319 Chemical Structure

PD 123319 Chemical Structure

CAS No. : 130663-39-7

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Top Publications Citing Use of Products

    PD 123319 purchased from MCE. Usage Cited in: FASEB J. 2018 Sep;32(9):5051-5062.

    HUVECs are starved for 12 h, treated with 10 mg/mL (9.56 μM) of AngII with or without Losartan or PD123319 for 12 h, and are subsequently used for Western blot analysis.
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    Description

    PD 123319 (ditrifluoroacetate) is a potent, selective AT2 angiotensin II receptor antagonist with IC50 of 34 nM.

    IC50 & Target

    IC50: 34 nM (AT2 Receptor)[1]

    In Vitro

    PD 123319 is shown to discriminate between two subclasses of AII receptors in many different tissues. 125I-AII specifically label two classes of binding sites for AII in a membrane preparation of bovine adrenal glomerulosa cells. The first class (DuP-753 sensitive) represents approximately 85% of the total binding sites for AII and possesses a high affinity (IC50 of 92.9 nM) for DuP-753. PD-123319 does not have any effect on 125I-AII binding to this site. The second class of binding sites is more sensitive to PD-123319, with an IC50 of 6.9 nM, and has a much lower affinity for DuP-753 (IC50 around 10 microM)[2]

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Molecular Weight

    508.61

    Formula

    C₃₁H₃₂N₄O₃

    CAS No.

    130663-39-7

    SMILES

    O=C([[email protected]@H]1CC2=C(N=CN2CC3=CC=C(N(C)C)C(C)=C3)CN1C(C(C4=CC=CC=C4)C5=CC=CC=C5)=O)O

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.

    References
    Animal Administration
    [3]

    The lower limit of CBF autoregulation is studied in 16 SHR. Eight animals receive PD 123319, while eight serve as controls. PD 123319 or saline is administered intravenously, and the BP is allowed to stabilise for 10 minutes after the injection and prior to the commencement of the autoregulation study. Haemorrhagic hypotension is subsequently induced by withdrawing blood into a syringe. By this means, BP is reduced stepwise to the lowest obtainable level. Throughout the study, CBF is measured at 10 to 15 mmHg BP intervals.

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    References
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    Keywords:

    PD 123319(S)-(+)-PD 123319PD123319PD-123319Angiotensin ReceptorInhibitorinhibitorinhibit

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    Product Name:
    PD 123319
    Cat. No.:
    HY-10259
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