1. GPCR/G Protein
  2. Angiotensin Receptor
  3. Angiotensin II human

Angiotensin II human (Synonyms: Angiotensin II; Hypertensin II; Ang II; DRVYIHPF)

Cat. No.: HY-13948 Purity: 99.96%
Handling Instructions

Angiotensin II human is a vasoconstrictor that acts on the AT1 and the AT2 receptor.

For research use only. We do not sell to patients.

Angiotensin II human Chemical Structure

Angiotensin II human Chemical Structure

CAS No. : 4474-91-3

Size Price Stock Quantity
10 mM * 1 mL in Water USD 86 In-stock
Estimated Time of Arrival: December 31
10 mg USD 75 In-stock
Estimated Time of Arrival: December 31
50 mg USD 300 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Other Forms of Angiotensin II human:

Top Publications Citing Use of Products

    Angiotensin II human purchased from MCE. Usage Cited in: Chinese Pharmacological Bulletin. 2017, 33(1): 63-67.

    Increase of H9c2 cell areas treated with angiotensin II.
    • Biological Activity

    • Protocol

    • Technical Information

    • Purity & Documentation

    • References

    Description

    Angiotensin II human is a vasoconstrictor that acts on the AT1 and the AT2 receptor.

    IC50 & Target

    Angiotensin receptor (AT receptor)[1]

    In Vitro

    Most of the known actions of Angiotensin II (Ang II) are mediated by AT1 receptors, the AT2 receptor contributes to the regulation of blood pressure and renal function[1]. Angiotensin II raises blood pressure (BP) by a number of actions, the most important ones being vasoconstriction, sympathetic nervous stimulation, increased aldosterone biosynthesis and renal actions. Other Angiotensin II actions include induction of growth, cell migration, and mitosis of vascular smooth muscle cells, increased synthesis of collagen type I and III in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. These actions are mediated by type 1 Ang II receptors (AT1)[2]. At the cellular level, responsiveness to Angiotensin II is conferred by the expression of the two classes of angiotensin receptors (AT1 and AT2). The effects of Angiotensin II to increase blood pressure are mediated by AT1 receptors[3].

    In Vivo

    To distinguish the AT1 receptor population that is critical for the pathogenesis of hypertension, osmotic minipumps are implanted s.c. into each animal to infuse Angiotensin II (1,000 ng/kg/min) continuously for 4 weeks. Angiotensin II causes hypertension by activating AT1 receptors in the kidney promoting sodium reabsorption[3].

    Clinical Trial
    Storage
    Protect from light, stored under nitrogen
    Powder -80°C 2 years
      -20°C 1 year
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    H2O : ≥ 50 mg/mL (47.79 mM)

    DMSO : 16.67 mg/mL (15.93 mM; Need ultrasonic)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 0.9559 mL 4.7793 mL 9.5586 mL
    5 mM 0.1912 mL 0.9559 mL 1.9117 mL
    10 mM 0.0956 mL 0.4779 mL 0.9559 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 0.83 mg/mL (0.79 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 0.83 mg/mL (0.79 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 0.83 mg/mL (0.79 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References
    Animal Administration
    [3]

    Mice[3]
    (129×C57BL/6) F1 mice lacking AT1A receptors for Angiotensin II are used. The mice are fed 10 gm/day gelled 0.25% NaCl diet that contains all nutrients and water. After 1 week of baseline collections, the animals are implanted with osmotic minipumps infusing Angiotensin II and are returned to the metabolic cage for 5 more days. Urinary sodium content is determined by using an IL943 Automatic Flame photometer. After 28 days of Angiotensin II infusion, hearts are harvested, weighed, fixed in formalin, sectioned, and stained with Masson trichrome. All of the tissues are examined by a pathologist (P.R.) without knowledge of genotypes.

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    References
    Molecular Weight

    1046.18

    Formula

    C₅₀H₇₁N₁₃O₁₂

    CAS No.

    4474-91-3

    Sequence

    Asp-Arg-Val-Tyr-Ile-His-Pro-Phe

    Sequence Shortening

    DRVYIHPF

    SMILES

    OC1=CC=C(C[[email protected]](NC([[email protected]@H](NC([[email protected]@H](CCCNC(N)=N)NC([[email protected]@H](N)CC(O)=O)=O)=O)C(C)C)=O)C(N[[email protected]]([[email protected]@H](C)CC)([H])C(N[[email protected]@H](CC2=CN=CN2)C(N3CCC[[email protected]@H]3C(N[[email protected]@H](C(O)=O)CC4=CC=CC=C4)=O)=O)=O)=O)C=C1

    Shipping

    Room temperature in continental US; may vary elsewhere

    Purity: 99.96%

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    This equation is commonly abbreviated as: C1V1 = C2V2

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    × = ×
    C1   V1   C2   V2

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    Product Name:
    Angiotensin II human
    Cat. No.:
    HY-13948
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    Angiotensin II human

    Cat. No.: HY-13948