1. GPCR/G Protein
    Apoptosis
  2. Angiotensin Receptor
    Apoptosis
  3. Angiotensin II human

Angiotensin II human (Synonyms: Angiotensin II; Ang II; DRVYIHPF)

Cat. No.: HY-13948 Purity: 99.96%
Handling Instructions

Angiotensine II humaine (angiotensine II) est un vasoconstricteur qui agit principalement sur le récepteur de AT1. Angiotensine II humaine stimule la stimulation nerveuse sympathique, augmente la biosynthèse de l'aldostérone et les actions rénales. Angiotensine II humaine induit la croissance des cellules musculaires lisses vasculaires, augmente la synthèse de collagène de type I et III dans les fibroblastes, conduisant à un épaississement de la paroi vasculaire et du myocarde, et à une fibrose. Angiotensine II humaine induit également l'apoptose.

Angiotensin II human (Angiotensin II) ist ein Vasokonstriktor, der hauptsächlich auf den AT1 receptor wirkt. Angiotensin II human stimuliert die sympathische Nervenstimulation, erhöht die Aldosteron-Biosynthese und die Nierentätigkeit. Angiotensin II human induziert das Wachstum von Zellen der glatten Gefäßmuskulatur, erhöht die Synthese von Kollagen Typ I und III in Fibroblasten, was zu einer Verdickung der Gefäßwand und des Myokards sowie zu Fibrose führt. Angiotensin II human induziert auch Apoptose.

Angiotensin II human (Angiotensin II) is a vasoconstrictor that mainly acts on the AT1 receptor. Angiotensin II human stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human also induces apoptosis.

For research use only. We do not sell to patients.

Angiotensin II human Chemical Structure

Angiotensin II human Chemical Structure

CAS No. : 4474-91-3

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mg USD 75 In-stock
Estimated Time of Arrival: December 31
50 mg USD 300 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 15 publication(s) in Google Scholar

Other Forms of Angiotensin II human:

Top Publications Citing Use of Products

    Angiotensin II human purchased from MCE. Usage Cited in: Int J Biochem Cell Biol. 2020 Jan 31;121:105703. 

    HPMCs are treated with 5.6 mM glucose (NG) or with 236 mM glucose (HG), or 100 nM AngII (AngII), or 236 mM glucose plus 10 mM valsartan (HGþvalsartan), or 100 nM AngII plus 10 mM valsartan (AngIIþvalsartan) for 24 h. The protein levels of p-mTOR, mTOR, p-4EBP1, 4EBP1, p-S6K1, and S6K1 are examined by Western blot analysis.
    • Biological Activity

    • Protocol

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Angiotensin II human (Angiotensin II) is a vasoconstrictor that mainly acts on the AT1 receptor. Angiotensin II human stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human also induces apoptosis[1][2].

    IC50 & Target

    Angiotensin receptor (AT receptor)[1]

    In Vitro

    Most of the known actions of Angiotensin II (Ang II) are mediated by AT1 receptors, the AT2 receptor contributes to the regulation of blood pressure and renal function[1]. Angiotensin II raises blood pressure (BP) by a number of actions, the most important ones being vasoconstriction, sympathetic nervous stimulation, increased aldosterone biosynthesis and renal actions. Other Angiotensin II actions include induction of growth, cell migration, and mitosis of vascular smooth muscle cells, increased synthesis of collagen type I and III in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. These actions are mediated by type 1 Ang II receptors (AT1)[2]. At the cellular level, responsiveness to Angiotensin II is conferred by the expression of the two classes of angiotensin receptors (AT1 and AT2). The effects of Angiotensin II to increase blood pressure are mediated by AT1 receptors[3].

    In Vivo

    To distinguish the AT1 receptor population that is critical for the pathogenesis of hypertension, osmotic minipumps are implanted s.c. into each animal to infuse Angiotensin II (1,000 ng/kg/min) continuously for 4 weeks. Angiotensin II causes hypertension by activating AT1 receptors in the kidney promoting sodium reabsorption[3].

    Clinical Trial
    Molecular Weight

    1046.18

    Formula

    C₅₀H₇₁N₁₃O₁₂

    CAS No.

    4474-91-3

    Sequence

    Asp-Arg-Val-Tyr-Ile-His-Pro-Phe

    Sequence Shortening

    DRVYIHPF

    SMILES

    O=C(N[[email protected]@H](CCCNC(N)=N)C(N[[email protected]@H](C(C)C)C(N[[email protected]@H](CC1=CC=C(C=C1)O)C(N[[email protected]@H]([[email protected]@H](C)CC)C(N[[email protected]@H](CC2=CNC=N2)C(N3[[email protected]@H](CCC3)C(N[[email protected]@H](CC4=CC=CC=C4)C(O)=O)=O)=O)=O)=O)=O)=O)[[email protected]](CC(O)=O)N

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.

    Solvent & Solubility
    In Vitro: 

    H2O : 50 mg/mL (47.79 mM; Need ultrasonic)

    DMSO : 16.67 mg/mL (15.93 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 0.9559 mL 4.7793 mL 9.5586 mL
    5 mM 0.1912 mL 0.9559 mL 1.9117 mL
    10 mM 0.0956 mL 0.4779 mL 0.9559 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 0.83 mg/mL (0.79 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 0.83 mg/mL (0.79 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 0.83 mg/mL (0.79 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References
    Animal Administration
    [3]

    Mice[3]
    (129×C57BL/6) F1 mice lacking AT1A receptors for Angiotensin II are used. The mice are fed 10 gm/day gelled 0.25% NaCl diet that contains all nutrients and water. After 1 week of baseline collections, the animals are implanted with osmotic minipumps infusing Angiotensin II and are returned to the metabolic cage for 5 more days. Urinary sodium content is determined by using an IL943 Automatic Flame photometer. After 28 days of Angiotensin II infusion, hearts are harvested, weighed, fixed in formalin, sectioned, and stained with Masson trichrome. All of the tissues are examined by a pathologist (P.R.) without knowledge of genotypes.

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    References

    Purity: 99.96%

    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.
    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

    Keywords:

    Angiotensin II humanAngiotensin IIAng IIDRVYIHPFAngiotensin ReceptorApoptosisInhibitorinhibitorinhibit

    Your Recently Viewed Products:

    Inquiry Online

    Your information is safe with us. * Required Fields.

    Product Name

     

    Salutation

    Applicant Name *

     

    Email address *

    Phone number *

     

    Organization name *

    Country or Region *

     

    Requested quantity *

    Remarks

    Bulk Inquiry

    Inquiry Information

    Product Name:
    Angiotensin II human
    Cat. No.:
    HY-13948
    Quantity:
    MCE Japan Authorized Agent: