1. GPCR/G Protein
  2. Angiotensin Receptor
  3. Angiotensin II human

Angiotensin II human (Synonyms: Angiotensin II; Hypertensin II; Ang II; DRVYIHPF)

Cat. No.: HY-13948 Purity: 99.96%
Handling Instructions

Angiotensin II human is a vasoconstrictor that acts on the AT1 and the AT2 receptor.

For research use only. We do not sell to patients.

Angiotensin II human Chemical Structure

Angiotensin II human Chemical Structure

CAS No. : 4474-91-3

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Based on 2 publication(s) in Google Scholar

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Description

Angiotensin II human is a vasoconstrictor that acts on the AT1 and the AT2 receptor.

IC50 & Target

Angiotensin receptor (AT receptor)[1]

In Vitro

Most of the known actions of Angiotensin II (Ang II) are mediated by AT1 receptors, the AT2 receptor contributes to the regulation of blood pressure and renal function[1]. Angiotensin II raises blood pressure (BP) by a number of actions, the most important ones being vasoconstriction, sympathetic nervous stimulation, increased aldosterone biosynthesis and renal actions. Other Angiotensin II actions include induction of growth, cell migration, and mitosis of vascular smooth muscle cells, increased synthesis of collagen type I and III in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. These actions are mediated by type 1 Ang II receptors (AT1)[2]. At the cellular level, responsiveness to Angiotensin II is conferred by the expression of the two classes of angiotensin receptors (AT1 and AT2). The effects of Angiotensin II to increase blood pressure are mediated by AT1 receptors[3].

In Vivo

To distinguish the AT1 receptor population that is critical for the pathogenesis of hypertension, osmotic minipumps are implanted s.c. into each animal to infuse Angiotensin II (1,000 ng/kg/min) continuously for 4 weeks. Angiotensin II causes hypertension by activating AT1 receptors in the kidney promoting sodium reabsorption[3].

Clinical Trial
Molecular Weight

1046.18

Formula

C₅₀H₇₁N₁₃O₁₂

CAS No.

4474-91-3

Sequence

Asp-Arg-Val-Tyr-Ile-His-Pro-Phe

Sequence Shortening

DRVYIHPF

SMILES

OC1=CC=C(C[[email protected]](NC([[email protected]@H](NC([[email protected]@H](CCCNC(N)=N)NC([[email protected]@H](N)CC(O)=O)=O)=O)C(C)C)=O)C(N[[email protected]]([[email protected]@H](C)CC)([H])C(N[[email protected]@H](CC2=CN=CN2)C(N3CCC[[email protected]@H]3C(N[[email protected]@H](C(O)=O)CC4=CC=CC=C4)=O)=O)=O)=O)C=C1

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Protect from light, stored under nitrogen
Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : ≥ 50 mg/mL (47.79 mM)

DMSO : 16.67 mg/mL (15.93 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9559 mL 4.7793 mL 9.5586 mL
5 mM 0.1912 mL 0.9559 mL 1.9117 mL
10 mM 0.0956 mL 0.4779 mL 0.9559 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 0.83 mg/mL (0.79 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 0.83 mg/mL (0.79 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 0.83 mg/mL (0.79 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Animal Administration
[3]

Mice[3]
(129×C57BL/6) F1 mice lacking AT1A receptors for Angiotensin II are used. The mice are fed 10 gm/day gelled 0.25% NaCl diet that contains all nutrients and water. After 1 week of baseline collections, the animals are implanted with osmotic minipumps infusing Angiotensin II and are returned to the metabolic cage for 5 more days. Urinary sodium content is determined by using an IL943 Automatic Flame photometer. After 28 days of Angiotensin II infusion, hearts are harvested, weighed, fixed in formalin, sectioned, and stained with Masson trichrome. All of the tissues are examined by a pathologist (P.R.) without knowledge of genotypes.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

Purity: 99.96%

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Angiotensin II human
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