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Angiotensin II human TFA

(Synonyms: Angiotensin II TFA; Ang II TFA; DRVYIHPF TFA)
248 Cited Publications
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Based on 248 publication(s) in Google Scholar

Angiotensin II human (Angiotensin II) TFA is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human TFA plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human TFA stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human TFA induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human TFA also induces apoptosis. Angiotensin II human TFA induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway.

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  • Pureza: 98.29%
  • No. CAS: 2761969-44-0
  • Fòrmula: C50H71N13O12.xC2HF3O2
  • Peso molecular:1046.18 (free acid)
  • Almacenamiento:

    Sealed storage, away from moisture and light, under nitrogen.

    Powder   -80°C, 2 years , -20°C, 1 year

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

  • Angiotensin II human TFA Chemical Structure
    Angiotensin II human TFA Chemical Structure
  • Experimental Validation Results for Angiotensin II human TFA
  • Experimental Validation Results for Angiotensin II human TFA
  • Experimental Validation Results for Angiotensin II human TFA
  • Experimental Validation Results for Angiotensin II human TFA
  • Experimental Validation Results for Angiotensin II human TFA
  • Experimental Validation Results for Angiotensin II human TFA
No. CAS: 2761969-44-0
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  • Angiotensin II human TFA Chemical Structure
    Angiotensin II human TFA Chemical Structure
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    Angiotensin II human TFA purchased from MedChemExpress. Usage Cited in: Mol Cell Endocrinol. 2023 Jul 1:571:111938. [Abstract]

    Customer Validation
     Angiotensin II human (Ang II; 1 μM; 48 h) increases the expression of MFN1, t-CaMKⅡ and p-CaMKⅡ and decreases the expression of SERCA2 in NMCMs.

  • 1/16

    Angiotensin II human TFA purchased from MedChemExpress. Usage Cited in: Biomedicines. 2022 Dec 4;10(12):3131. [Abstract]

    Customer Validation
     Angiotensin II human (Ang II; 100 nM; 24 h) pretreatment significantly increases both the protein level of CtBP1 during 3T3-L1 adipogenesis.

  • 1/16

    Angiotensin II human TFA purchased from MedChemExpress. Usage Cited in: Biomedicines. 2022 Dec 4;10(12):3131. [Abstract]

    Customer Validation
     Angiotensin II human (Ang II; 100 nM; 24 h) pretreatment significantly increases both the mRNA level of CtBP1 during 3T3-L1 adipogenesis.

  • 1/16

    Angiotensin II human TFA purchased from MedChemExpress. Usage Cited in: Sci Transl Med. 2021 Jul 21;13(603):eaaz4959. [Abstract]

    Customer Validation
     Cultured human renal 786-O cells were stimulated with vehicle, AngII (50 μM), AngII + Telmisartan (1 μM), AngII + PD123319 (50 μM) for 12 hrs. Cells were harvested and EPO protein abundance was detected by Western blot.

  • 1/16

    Angiotensin II human TFA purchased from MedChemExpress. Usage Cited in: Sci Transl Med. 2021 Jul 21;13(603):eaaz4959. [Abstract]

    Customer Validation
     SMC was stimulated with vehicle and AngII of 10-8 M, 10-7 M, 10-6 M,10-5 M and 10-4 M, respectively, for 24 hrs. Cells were harvested and EPO protein abundance measured by Western blot.

  • 1/16

    Angiotensin II human TFA purchased from MedChemExpress. Usage Cited in: Int J Biochem Cell Biol. 2020 Apr:121:105703. [Abstract]

    Customer Validation
     HPMCs are treated with 5.6 mM glucose (NG) or with 236 mM glucose (HG), or 100 nM AngII (AngII), or 236 mM glucose plus 10 mM valsartan (HGþvalsartan), or 100 nM AngII plus 10 mM valsartan (AngIIþvalsartan) for 24 h. The protein levels of p-mTOR, mTOR, p-4EBP1, 4EBP1, p-S6K1, and S6K1 are examined by Western blot analysis.

  • Angiotensin II human TFA