1. GPCR/G Protein
    Apoptosis
  2. Angiotensin Receptor
    Apoptosis
  3. Angiotensin II human acetate

Angiotensin II human acetate (Synonyms: Angiotensin II acetate; Ang II acetate; DRVYIHPF acetate)

Cat. No.: HY-13948A Purity: 99.79%
Handling Instructions

Angiotensin II human (Angiotensin II) acetate is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human acetate plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human acetate stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human acetate induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human acetate also induces apoptosis. Angiotensin II human acetate induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Angiotensin II human acetate Chemical Structure

Angiotensin II human acetate Chemical Structure

CAS No. : 68521-88-0

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Based on 50 publication(s) in Google Scholar

Other Forms of Angiotensin II human acetate:

Top Publications Citing Use of Products

49 Publications Citing Use of MCE Angiotensin II human acetate

    Angiotensin II human acetate purchased from MCE. Usage Cited in: Int J Biochem Cell Biol. 2020 Apr;121:105703.

    HPMCs are treated with 5.6 mM glucose (NG) or with 236 mM glucose (HG), or 100 nM AngII (AngII), or 236 mM glucose plus 10 mM valsartan (HGþvalsartan), or 100 nM AngII plus 10 mM valsartan (AngIIþvalsartan) for 24 h. The protein levels of p-mTOR, mTOR, p-4EBP1, 4EBP1, p-S6K1, and S6K1 are examined by Western blot analysis.
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    Description

    Angiotensin II human (Angiotensin II) acetate is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human acetate plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human acetate stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human acetate induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human acetate also induces apoptosis. Angiotensin II human acetate induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway[1][2][3][4].

    In Vitro

    Most of the known actions of Angiotensin II (Ang II) human acetate are mediated by AT1 receptors, the AT2 receptor contributes to the regulation of blood pressure and renal function[1].
    Angiotensin II human acetate raises blood pressure (BP) by a number of actions, the most important ones being vasoconstriction, sympathetic nervous stimulation, increased aldosterone biosynthesis and renal actions. Other Angiotensin II human acetate actions include induction of growth, cell migration, and mitosis of vascular smooth muscle cells, increased synthesis of collagen type I and III in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. These actions are mediated by type 1 Ang II receptors (AT1)[2].
    Angiotensin II (1 nM) induces the expression of LOX-1 and VEGF and enhances capillary formation from human coronary endothelial cells in Matrigel assay. Angiotensin II -mediated expression of LOX-1 and VEGF, capillary formation, intracellular reactive oxygen species generation, and phosphorylation of p38 as well as p44/42 mitogen-activated protein kinases, were suppressed by anti-LOX-1 antibody, nicotinamide-adenine dinucleotide phosphate oxidase inhibitor apocynin and the Ang II type 1 receptor blocker Losartan, but not by the Ang II type 2 receptor blocker PD123319[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    In Vivo

    Angiotensin II human (5 mL of 1 nM; intraperitoneal injection; 200-250 g Sprague-Dawley rats) acetate induces a significant neutrophil recruitment that was maximal at 4 hours and had resolved by 24 hours[4].
    To distinguish the AT1 receptor population that is critical for the pathogenesis of hypertension, osmotic minipumps are implanted s.c. into each animal to infuse Angiotensin II human (1000 ng/kg/min) acetate continuously for 4 weeks. Angiotensin II human acetate causes hypertension by activating AT1 receptors in the kidney promoting sodium reabsorption[5].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Clinical Trial
    Molecular Weight

    1106.23

    Formula

    C52H75N13O14

    CAS No.
    Sequence

    Asp-Arg-Val-Tyr-Ile-His-Pro-Phe

    Sequence Shortening

    DRVYIHPF

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    Sealed storage, away from moisture

    Powder -80°C 2 years
    -20°C 1 year

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    H2O : 25 mg/mL (22.60 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 0.9040 mL 4.5199 mL 9.0397 mL
    5 mM 0.1808 mL 0.9040 mL 1.8079 mL
    10 mM 0.0904 mL 0.4520 mL 0.9040 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  Saline

      Solubility: 16.67 mg/mL (15.07 mM); Clear solution; Need ultrasonic

    *All of the co-solvents are available by MCE.
    Purity & Documentation

    Purity: 99.79%

    References
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    Product Name:
    Angiotensin II human acetate
    Cat. No.:
    HY-13948A
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