1. Metabolic Enzyme/Protease
  2. Mineralocorticoid Receptor
  3. Eplerenone

Eplerenone (Synonyms: Epoxymexrenone)

Cat. No.: HY-B0251 Purity: 99.68%
Handling Instructions

Eplerenone (Epoxymexrenone) is a selective, competitive and oreally active aldosterone antagonist with an IC50 of 138 nM. Eplerenone has low affinity for progesterone, androgen, estrogen and glucocorticoid receptors. Eplerenone can be used for hypertension and heart failure after myocardial infarction reserch.

For research use only. We do not sell to patients.

Eplerenone Chemical Structure

Eplerenone Chemical Structure

CAS No. : 107724-20-9

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 88 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 88 In-stock
Estimated Time of Arrival: December 31
Solid
10 mg USD 80 In-stock
Estimated Time of Arrival: December 31
50 mg USD 235 In-stock
Estimated Time of Arrival: December 31
100 mg USD 322 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 4 publication(s) in Google Scholar

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Description

Eplerenone (Epoxymexrenone) is a selective, competitive and oreally active aldosterone antagonist with an IC50 of 138 nM. Eplerenone has low affinity for progesterone, androgen, estrogen and glucocorticoid receptors. Eplerenone can be used for hypertension and heart failure after myocardial infarction reserch[1][2].

IC50 & Target

IC50: 138 nM (Mineralocorticoid receptor)[2]

Clinical Trial
Molecular Weight

414.49

Formula

C₂₄H₃₀O₆

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (60.32 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4126 mL 12.0630 mL 24.1260 mL
5 mM 0.4825 mL 2.4126 mL 4.8252 mL
10 mM 0.2413 mL 1.2063 mL 2.4126 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.03 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.03 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.03 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
Eplerenone
Cat. No.:
HY-B0251
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