Hyperthyroidism

Hyperthyroidism is an endocrine disorder characterized by the overproduction and release of thyroid hormones by the thyroid gland, leading to thyrotoxicosis and a wide range of systemic effects. Common symptoms include nervousness, irritability, weight loss, heat intolerance, palpitations, tremors, fatigue, muscle weakness, insomnia, and changes in menstrual cycles. In severe cases, it can progress to thyroid storm, a life-threatening condition. The most frequent cause is Graves' disease, an autoimmune disorder, though other causes include toxic multinodular goiter and thyroiditis. Left untreated, hyperthyroidism can lead to serious complications such as atrial fibrillation, heart failure, osteoporosis, and infertility. Treatment options include antithyroid medications, radioactive iodine therapy, and surgery, with the goal of normalizing hormone levels and alleviating symptoms.

References:

[1]. Hyperthyroidism. sciencedirect.

Hyperthyroidism (4):

Targets:	FXR (3) VD/VDR (1)

Cat. No.	Product Name	CAS No.	Purity	Chemical Structure

HY-13995

Sevelamer	52757-95-6
Sevelamer is an orally active polymeric phosphate binder and bile acid sequestrant. Sevelamer binds dietary phosphate in the gastrointestinal tract, reducing phosphate absorption and serum phosphorus levels, and reduces urinary phosphate excretion. Sevelamer binds polyanion bile acids, increases bile acid faecal excretion, and reduces total cholesterol and LDL cholesterol levels. Sevelamer can be used for the research of hyperphosphataemia, hyperparathyroidism, chronic renal failure, kidney disease, and type 2 diabetes.

HY-13995B

Sevelamer carbonate	845273-93-0
Sevelamer carbonate is an orally active polymeric phosphate binder and bile acid sequestrant. Sevelamer carbonate binds dietary phosphate in the gastrointestinal tract, reducing phosphate absorption and serum phosphorus levels, and reduces urinary phosphate excretion. Sevelamer carbonate binds polyanion bile acids, increases bile acid faecal excretion, and reduces total cholesterol and LDL cholesterol levels. Sevelamer carbonate can be used for the research of hyperphosphataemia, hyperparathyroidism, chronic renal failure, kidney disease, and type 2 diabetes.

HY-13995A

Sevelamer hydrochloride	152751-57-0	98.0%
Sevelamer hydrochloride is an orally active polymeric phosphate binder and bile acid sequestrant. Sevelamer hydrochloride binds dietary phosphate in the gastrointestinal tract, reducing phosphate absorption and serum phosphorus levels, and reduces urinary phosphate excretion. Sevelamer hydrochloride binds polyanion bile acids, increases bile acid faecal excretion, and reduces total cholesterol and LDL cholesterol levels. Sevelamer hydrochloride can be used for the research of hyperphosphataemia, hyperparathyroidism, chronic renal failure, kidney disease, and type 2 diabetes.

HY-180503

19-Nor-22-oxa-1a,25(OH)2-VD3	284041-36-7
19-Nor-22-oxa-1a,25(OH)2-VD3 is a vitamin D₃ analogue. 19-Nor-22-oxa-1a,25(OH)2-VD3 has an extremely low affinity for the vitamin D receptor (VDR) and hardly binds to the vitamin D binding protein (DBP). 19-Nor-22-oxa-1a,25(OH)2-VD3 can effectively induce the differentiation of HL-60 cells and cause G₀-G₁ phase cell cycle arrest. 19-Nor-22-oxa-1a,25(OH)2-VD3 can be used to study diseases such as excessive hyperparathyroidism.

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