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Sevelamer carbonate 

Cat. No.: HY-13995B
Handling Instructions

Sevelamer carbonate is an orally active and non-calcium-based phosphate binding agent and used for the hyperphosphatemia of chronic kidney disease (CKD)research. Sevelamer carbonate effectively lowers serum phosphorus levels hile having minimal effect on serum calcium or serum chloride levels in vivo. Sevelamer carbonate is considered as an improved, buffered form of sevelamer (HY-13995).

For research use only. We do not sell to patients.

Sevelamer carbonate Chemical Structure

Sevelamer carbonate Chemical Structure

CAS No. : 845273-93-0

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Description

Sevelamer carbonate is an orally active and non-calcium-based phosphate binding agent and used for the hyperphosphatemia of chronic kidney disease (CKD)research. Sevelamer carbonate effectively lowers serum phosphorus levels hile having minimal effect on serum calcium or serum chloride levels in vivo. Sevelamer carbonate is considered as an improved, buffered form of sevelamer (HY-13995)[1][2].

In Vivo

Sevelamer carbonate is an anion-exchange resin with the same polymeric structure as that of sevelamer hydrochloride, but with carbonate replacing chloride as the anion[4].
Sevelamer carbonate lowers serum phosphorus levels and calcium-phosphorus product to a similar extent as sevelamer hydrochloride. Additionally, Sevelamer carbonate is associated with significant effects on decreasing low-density lipoprotein cholesterol levels and may cause less metabolic acidosis than sevelamer hydrochloride in vivo[1].
Sevelamer carbonate (oral adminstration; 1% mixed in diet; 2-3 weeks) significantly reduces serum phosphate level in Npt2b-deficient mice. Npt2b attenuates the hyperphosphatemia in control animals and that sevelamer carbonate treatment has an additional benefit in maintaining serum phosphate in the normal range[3].
Sevelamer carbonate (oral adminstration;  1% mixed in diet; 2-3 weeks) does not alter serum phosphate levels in uremic WT mice (10.04 mg/dl , untreated versus 9.67mg/dl , binder-treated mg/dl) but further decreased serum phosphate levels in uremic Npt2b−/− mice in uremic mouse model[3].

Animal Model: WT and Npt2b−/− CKD mice model[3]
Dosage: 1% mixed in diet
Administration: Oral adminstration; 1% mixed in diet; 2-3 weeks
Result: Attenuated chronic hyperphosphatemia in mice.
Formula

(C₃H₇N.C₃H₅ClO)x.xCH₂O₃

CAS No.

845273-93-0

SMILES

NCC(CC(CC)CNCC(O)CNCC(C)CC(CC)CN)CC.[m].[c].[b].[a].[m H2CO3]

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

SevelamerOthersChronickidneydiseaseantiproteinurirenin-angiotensin systemRAS blockerphosphate binderanion-exchange resinInhibitorinhibitorinhibit

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Sevelamer carbonate
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HY-13995B
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