2. GPCR/G Protein Apoptosis
  3. Angiotensin Receptor Apoptosis
  4. Irbesartan

Irbesartan  (Synonyms: SR-47436; BMS-186295)

Cat. No.: HY-B0202 Purity: 99.26%
COA Handling Instructions

Irbesartan (SR-47436) is an orally active Ang II type 1 (AT1) receptor blocker (ARB). Irbesartan can relax the blood vessels, low blood pressure and increase the supply of blood and oxygen to the heart. Irbesartan can be used for the research of high blood pressure, heart failure, and diabetic kidney disease.

For research use only. We do not sell to patients.

Irbesartan Chemical Structure

Irbesartan Chemical Structure

CAS No. : 138402-11-6

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Solution
10 mM * 1 mL in DMSO USD 66 In-stock
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ready for reconstitution
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Solid
5 mg USD 38 In-stock
10 mg USD 60 In-stock
50 mg USD 106 In-stock
100 mg USD 180 In-stock
200 mg USD 228 In-stock
500 mg USD 264 In-stock
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Customer Review

Based on 4 publication(s) in Google Scholar

Other Forms of Irbesartan:

Irbesartan Related Antibodies

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Description

Irbesartan (SR-47436) is an orally active Ang II type 1 (AT1) receptor blocker (ARB). Irbesartan can relax the blood vessels, low blood pressure and increase the supply of blood and oxygen to the heart. Irbesartan can be used for the research of high blood pressure, heart failure, and diabetic kidney disease[1].

In Vitro

Irbesartan (20 μM, 3 h) reduces Th22 cells chemotaxis in vitro[1].
Irbesartan (0 μM, 20 μM, 40 μM and 60 μM) suppresses Th22 cells differentiation in vitro[1].
Irbesartan (20 μM) inhibits Th22 cells related proinflammatory response of TECs in vitro[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Irbesartan Related Antibodies

Cell Viability Assay[1]

Cell Line: CD4+ T cells
Concentration: 0, 20, 40 and 60 μM
Incubation Time: 48 h
Result: Exerted no obvious effect on viability of CD4+T cells.
In Vivo

Irbesartan (oral gavage; 50 mg/kg/d; once daily) reduces Th22 lymphocytosis and serum IL-22 level in Ang II-infused mice[1].
Irbesartan (oral gavage; 50 mg/kg/d; once daily) exerts obvious renoprotective effects[1].
Irbesartan (oral gavage; 50 mg/kg/d; once daily) relieves systemic inflammation and renal fibrosis in hypertension mice induced by Ang II[1].
Irbesartan hydrochloride (20 μM; for 3 h) can attenuate Th22 cells recruitment and IL-22 secretion, which might be through inhibiting chemotaxis in hypertensive renal injury mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice[1]
Dosage: 50 mg/kg
Administration: oral gavage; 50 mg/kg/d; once daily
Result: Displayed low Th22 cells and IL-22, exerted similar inhibitory effect on Th1 cell proportion and displayed decreased IL-22 level in kidney.
Prevented BP elevation markedly and decreased urinary albumin/creatinine ratio, BUN and Scr.
Repressed the expression of IL-1β, IL-6, TNF-α, α-SMA, FN and Col I and diminished the extent of fibrosis.
Animal Model: C57BL/6 mice[1]
Dosage: 20 μM
Administration: 20 μM; for 3 h
Result: Downregulated renal CCL20, CCL22 and CCL27 concentrations.
Clinical Trial
Molecular Weight

428.53

Appearance

Solid

Formula

C25H28N6O
CAS No.
SMILES

O=C1N(CC2=CC=C(C3=C(C4=NN=NN4)C=CC=C3)C=C2)C(CCCC)=NC15CCCC5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (233.36 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3336 mL 11.6678 mL 23.3356 mL
5 mM 0.4667 mL 2.3336 mL 4.6671 mL
10 mM 0.2334 mL 1.1668 mL 2.3336 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.83 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.83 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.83 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Irbesartan Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Irbesartan138402-11-6SR-47436 BMS-186295SR47436SR 47436BMS186295BMS 186295BMS-186295Angiotensin ReceptorApoptosisAng II type 1 (AT1) receptor blocker (ARB)blood vesselsbloodheart failurechemotaxishypertensive renal injuryTh22 cellsdiabetic kidney diseaseInhibitorinhibitorinhibit

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