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Cat. No.: HY-B0202A

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Irbesartan hydrochloride

(Synonyms: SR-47436 hydrochloride; BMS-186295 hydrochloride)

8 Cited Publications

Customer Review

Based on 8 publication(s) in Google Scholar

Irbesartan (SR-47436) hydrochloride is an orally active Ang II type 1 (AT1) receptor blocker (ARB). Irbesartan hydrochloride can relax the blood vessels, low blood pressure and increase the supply of blood and oxygen to the heart. Irbesartan hydrochloride can be used for the research of high blood pressure, heart failure, and diabetic kidney disease.

For research use only. We do not sell to patients.

CAS No.: 329055-23-4
Formula: C₂₅H₂₉ClN₆O
Molecular Weight:464.99

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (278 KB)

Irbesartan hydrochloride Chemical Structure

CAS No.: 329055-23-4

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Publications (8)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Angiotensin Receptor Isoforms :

In Vitro

Irbesartan hydrochloride (20 μM, 3 h) reduces Th22 cells chemotaxis in vitro^[1].
Irbesartan hydrochloride (0 μM, 20 μM, 40 μM and 60 μM) suppresses Th22 cells differentiation in vitro^[1].
Irbesartan hydrochloride (20 μM) inhibits Th22 cells related proinflammatory response of TECs in vitro^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

CD4⁺ T cells
Concentration:

0, 20, 40 and 60 μM
Incubation Time:

48 h
Result:

Exerted no obvious effect on viability of CD4⁺T cells.

In Vivo

Irbesartan hydrochloride (oral gavage; 50 mg/kg/d; once daily) reduces Th22 lymphocytosis and serum IL-22 level in Ang II-infused mice^[1].
Irbesartan hydrochloride (oral gavage; 50 mg/kg/d; once daily) exerts obvious renoprotective effects^[1].
Irbesartan hydrochloride (oral gavage; 50 mg/kg/d; once daily) relieves systemic inflammation and renal fibrosis in hypertension mice induced by Ang II^[1].
Irbesartan hydrochloride (20 μM; for 3 h) can attenuate Th22 cells recruitment and IL-22 secretion, which might be through inhibiting chemotaxis in hypertensive renal injury mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6 mice^[1]
Dosage:

50 mg/kg
Administration:

oral gavage; 50 mg/kg/d; once daily
Result:

Displayed low Th22 cells and IL-22, exerted similar inhibitory effect on Th1 cell proportion and displayed decreased IL-22 level in kidney.
Prevented BP elevation markedly and decreased urinary albumin/creatinine ratio, BUN and Scr.
Repressed the expression of IL-1β, IL-6, TNF-α, α-SMA, FN and Col I and diminished the extent of fibrosis.

Animal Model:

C57BL/6 mice^[1]
Dosage:

20 μM
Administration:

20 μM; for 3 h
Result:

Downregulated renal CCL20, CCL22 and CCL27 concentrations.

Chemical Information

CAS No. 329055-23-4
Molecular Weight 464.99
Formula C₂₅H₂₉ClN₆O
SMILES

O=C1N(CC2=CC=C(C3=C(C4=NN=NN4)C=CC=C3)C=C2)C(CCCC)=NC15CCCC5.[H]Cl
Synonyms

SR-47436 hydrochloride; BMS-186295 hydrochloride
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (8)

All WBCell Imaging/StainingIn Vivo Efficacy StudyIF

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Journal Impact Factor

J Exp Clin Cancer Res

Irbesartan overcomes gemcitabine resistance in pancreatic cancer by suppressing stemness and iron metabolism via inhibition of the Hippo/YAP1/c-Jun axis. [Abstract]

2023 May 4;42(1):111. PMID: 37143164

Irbesartan hydrochloride purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2023 May 4;42(1):111. [Abstract]

The apoptosis of organoids treated with GEM (0.8 μM) and Irbesartan (1 μM) for 72 h was determined by western blot for cleaved-caspase 3/7. Tubulin was used as loading control.

Irbesartan hydrochloride purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2023 May 4;42(1):111. [Abstract]

Organoids were treated with vehicle, GEM (0.8 μM), irbesartan (1 μM) and GEM (0.8 μM) plus irbesartan (1 μM), followed by continually monitoring PDAC organoid apoptosis by real-time caspase3/7 probe imaging for 72 h.

Irbesartan hydrochloride purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2023 May 4;42(1):111. [Abstract]

Irbesartan (20 mg/kg; po; twice a week) plus GEM significantly reduced the weight of pancreatic tumor.

Irbesartan hydrochloride purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2023 May 4;42(1):111. [Abstract]

Irbesartan (20 mg/kg; po; twice a week) induced apoptosis in mouse pancreatic tumor tissues.

Irbesartan hydrochloride purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2023 May 4;42(1):111. [Abstract]

Irbesartan (20 mg/kg; po; twice a week) decreased the percent of Ki67 positive cells in mouse pancreatic tumor tissues.
J Immunother Cancer

Telmisartan increases olaparib efficacy in homologous recombination proficient tumors by augmenting type I interferon production. [Abstract]

2026 Mar 25;14(3):e012426. PMID: 41881499
Int J Biol Macromol

An injectable polyacrylamide/chitosan-based hydrogel with highly adhesive, stretchable and electroconductive properties loaded with irbesartan for treatment of myocardial ischemia-reperfusion injury. [Abstract]

2024 May;266(Pt 1):131175. PMID: 38552696
Phytother Res

Saikosaponin D Regulates HK2-Mediated Glycolytic Lactate Signaling to Alleviate CKD-Induced Renal Fibrosis. [Abstract]

2026 Feb;40(2):812-828. PMID: 41508401
Atherosclerosis

RhoGDI stability is regulated by SUMOylation and ubiquitination via the AT1 receptor and participates in Ang II-induced smooth muscle proliferation and vascular remodeling. [Abstract]

2019 Sep:288:124-136. PMID: 31362179
Biomedicines

Comparative Proteomic Analysis of tPVAT during Ang II Infusion. [Abstract]

2021 Dec 2;9(12):1820. PMID: 34944635
FASEB J

Hirudin Ameliorates Kidney Injury in DKD Mice by Decreasing SOD2 β-Hydroxybutyrylation Mediated ROS Level and NLRP3 Inflammasome Formation. [Abstract]

2026 Jan 31;40(2):e71433. PMID: 41546551
Saudi Pharm J

Study of influence of Catha edulis (Khat) chewing on oral pharmacokinetics of irbesartan in rats using a newly developed HPLC-UV method. [Abstract]

2022 Mar;30(3):237-244. PMID: 35498225

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (278 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yong Zhong, et al. Irbesartan may relieve renal injury by suppressing Th22 cells chemotaxis and infiltration in Ang II-induced hypertension. Int Immunopharmacol [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Irbesartan hydrochloride

8 Cited Publications

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Publications (8)
Purity & Documentation
References

1/16
1/16

Irbesartan hydrochloride purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2023 May 4;42(1):111. [Abstract]

Customer Validation
The apoptosis of organoids treated with GEM (0.8 μM) and Irbesartan (1 μM) for 72 h was determined by western blot for cleaved-caspase 3/7. Tubulin was used as loading control.
1/16

Irbesartan hydrochloride purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2023 May 4;42(1):111. [Abstract]

Customer Validation
Organoids were treated with vehicle, GEM (0.8 μM), irbesartan (1 μM) and GEM (0.8 μM) plus irbesartan (1 μM), followed by continually monitoring PDAC organoid apoptosis by real-time caspase3/7 probe imaging for 72 h.
1/16

Irbesartan hydrochloride purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2023 May 4;42(1):111. [Abstract]

Customer Validation
Irbesartan (20 mg/kg; po; twice a week) plus GEM significantly reduced the weight of pancreatic tumor.
1/16

Irbesartan hydrochloride purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2023 May 4;42(1):111. [Abstract]

Customer Validation
Irbesartan (20 mg/kg; po; twice a week) induced apoptosis in mouse pancreatic tumor tissues.
1/16

Irbesartan hydrochloride purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2023 May 4;42(1):111. [Abstract]

Customer Validation
Irbesartan (20 mg/kg; po; twice a week) decreased the percent of Ki67 positive cells in mouse pancreatic tumor tissues.

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Irbesartan hydrochloride

Publications Citing Use of MedChemExpress (MCE) Irbesartan hydrochloride

All Angiotensin Receptor Isoforms

Biological Activity

Chemical Information

Publications (8)

Purity & Documentation

References

Calculators

Help & FAQs

Irbesartan hydrochloride Related Classifications

HY-B0202A Related Classifications