2. GPCR/G Protein Apoptosis
  3. Angiotensin Receptor Apoptosis
  4. Irbesartan hydrochloride

Irbesartan hydrochloride  (Synonyms: SR-47436 hydrochloride; BMS-186295 hydrochloride)

Cat. No.: HY-B0202A
Handling Instructions Technical Support

Irbesartan (SR-47436) hydrochloride is an orally active Ang II type 1 (AT1) receptor blocker (ARB). Irbesartan hydrochloride can relax the blood vessels, low blood pressure and increase the supply of blood and oxygen to the heart. Irbesartan hydrochloride can be used for the research of high blood pressure, heart failure, and diabetic kidney disease.

For research use only. We do not sell to patients.

CAS No. : 329055-23-4

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Other In-stock Forms of Irbesartan hydrochloride:

Other Forms of Irbesartan hydrochloride:

Irbesartan hydrochloride Related Antibodies

Top Publications Citing Use of Products

    Irbesartan hydrochloride purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2023 May 4;42(1):111.  [Abstract]

    The apoptosis of organoids treated with GEM (0.8 μM) and Irbesartan (1 μM) for 72 h was determined by western blot for cleaved-caspase 3/7. Tubulin was used as loading control.

    Irbesartan hydrochloride purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2023 May 4;42(1):111.  [Abstract]

    Organoids were treated with vehicle, GEM (0.8 μM), irbesartan (1 μM) and GEM (0.8 μM) plus irbesartan (1 μM), followed by continually monitoring PDAC organoid apoptosis by real-time caspase3/7 probe imaging for 72 h.

    Irbesartan hydrochloride purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2023 May 4;42(1):111.  [Abstract]

    Irbesartan (20 mg/kg; po; twice a week) plus GEM significantly reduced the weight of pancreatic tumor.

    Irbesartan hydrochloride purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2023 May 4;42(1):111.  [Abstract]

    Irbesartan (20 mg/kg; po; twice a week) induced apoptosis in mouse pancreatic tumor tissues.

    Irbesartan hydrochloride purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2023 May 4;42(1):111.  [Abstract]

    Irbesartan (20 mg/kg; po; twice a week) decreased the percent of Ki67 positive cells in mouse pancreatic tumor tissues.

    View All Angiotensin Receptor Isoform Specific Products:

    View All Isoforms
    AT1 Receptor AT2 Receptor

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Irbesartan (SR-47436) hydrochloride is an orally active Ang II type 1 (AT1) receptor blocker (ARB). Irbesartan hydrochloride can relax the blood vessels, low blood pressure and increase the supply of blood and oxygen to the heart. Irbesartan hydrochloride can be used for the research of high blood pressure, heart failure, and diabetic kidney disease[1].

    In Vitro

    Irbesartan hydrochloride (20 μM, 3 h) reduces Th22 cells chemotaxis in vitro[1].
    Irbesartan hydrochloride (0 μM, 20 μM, 40 μM and 60 μM) suppresses Th22 cells differentiation in vitro[1].
    Irbesartan hydrochloride (20 μM) inhibits Th22 cells related proinflammatory response of TECs in vitro[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Irbesartan hydrochloride Related Antibodies

    Cell Viability Assay[1]

    Cell Line: CD4+ T cells
    Concentration: 0, 20, 40 and 60 μM
    Incubation Time: 48 h
    Result: Exerted no obvious effect on viability of CD4+T cells.
    In Vivo

    Irbesartan hydrochloride (oral gavage; 50 mg/kg/d; once daily) reduces Th22 lymphocytosis and serum IL-22 level in Ang II-infused mice[1].
    Irbesartan hydrochloride (oral gavage; 50 mg/kg/d; once daily) exerts obvious renoprotective effects[1].
    Irbesartan hydrochloride (oral gavage; 50 mg/kg/d; once daily) relieves systemic inflammation and renal fibrosis in hypertension mice induced by Ang II[1].
    Irbesartan hydrochloride (20 μM; for 3 h) can attenuate Th22 cells recruitment and IL-22 secretion, which might be through inhibiting chemotaxis in hypertensive renal injury mice[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: C57BL/6 mice[1]
    Dosage: 50 mg/kg
    Administration: oral gavage; 50 mg/kg/d; once daily
    Result: Displayed low Th22 cells and IL-22, exerted similar inhibitory effect on Th1 cell proportion and displayed decreased IL-22 level in kidney.
    Prevented BP elevation markedly and decreased urinary albumin/creatinine ratio, BUN and Scr.
    Repressed the expression of IL-1β, IL-6, TNF-α, α-SMA, FN and Col I and diminished the extent of fibrosis.
    Animal Model: C57BL/6 mice[1]
    Dosage: 20 μM
    Administration: 20 μM; for 3 h
    Result: Downregulated renal CCL20, CCL22 and CCL27 concentrations.
    Molecular Weight

    464.99

    Formula

    C25H29ClN6O
    CAS No.
    SMILES

    O=C1N(CC2=CC=C(C3=C(C4=NN=NN4)C=CC=C3)C=C2)C(CCCC)=NC15CCCC5.[H]Cl
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.

    Irbesartan hydrochloride Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Irbesartan329055-23-4SR-47436BMS-186295SR47436SR 47436BMS186295BMS 186295Angiotensin ReceptorApoptosisAng II type 1 (AT1) receptor blocker (ARB)blood vesselsbloodheart failurechemotaxishypertensive renal injuryTh22 cellsdiabetic kidney diseaseInhibitorinhibitorinhibit

    Your Recently Viewed Products:

    Inquiry Online

    Your information is safe with us. * Required Fields.

    Product Name

    		  

    Requested Quantity *

    Applicant Name *

    		 

    Salutation

    Email Address *

    		 

    Phone Number *

    Department

    		 

    Organization Name *

    City

    State

    Country or Region *

    		      

    Remarks

    Bulk Inquiry

    Inquiry Information

    Product Name:
    Irbesartan hydrochloride
    Cat. No.:
    HY-B0202A
    Quantity:
    MCE Japan Authorized Agent:

    Customer Review

    Thank You for Your Feedback!

    Request for HNMR Report

    Please fill out this form to request the QC report. We will send it to your Email address shortly.

    Your information is safe with us. * Required Fields.

    Product Name

    		  

    Lot #

    Applicant Name *

    		 

    Email Address *

    Phone Number

    		 

    Department *

    Organization Name *

    		 

    Country or Region *

    Remarks

    SAFETY DATA SHEET (SDS)

    Request for HNMR Report

    We have received your request and will respond to you as soon as possible.