2. Immunology/Inflammation Vitamin D Related/Nuclear Receptor
  3. Glucocorticoid Receptor
  4. Flumethasone pivalate

Flumethasone pivalate  (Synonyms: Flumethasone 21-pivalate)

Cat. No.: HY-107949 Purity: 98.17%
COA
SDS
Handling Instructions Technical Support

Flumethasone pivalate (Flumethasone 21-pivalate) is a glucocorticoid and a topical corticosteroid with anti-inflammatory, antipruritic, and vasoconstrictive actions. Flumethasone pivalate inhibits foreign body granuloma formation. Flumethasone pivalate can be used for the researches of dermatitis, eczema, and psoriasis.

For research use only. We do not sell to patients.

Flumethasone pivalate

Flumethasone pivalate Chemical Structure

CAS No. : 2002-29-1

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO In-stock
Solid
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5 mg In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Flumethasone pivalate:

Flumethasone pivalate Related Antibodies

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Description

Flumethasone pivalate (Flumethasone 21-pivalate) is a glucocorticoid and a topical corticosteroid with anti-inflammatory, antipruritic, and vasoconstrictive actions. Flumethasone pivalate inhibits foreign body granuloma formation. Flumethasone pivalate can be used for the researches of dermatitis, eczema, and psoriasis[1][2].

In Vivo

Flumethasone pivalate (0.03% in cream; local; via cotton pellet impregnation; 6 days) exhibits potent local anti-inflammatory activity in rat foreign body granuloma models, with minimal systemic effects at efficacious local doses[2].
Flumethasone pivalate (30 μg/kg; p.o.; daily; gestational days 1-14) administered to pregnant rats during early gestation causes reduced newborn pup weight and and death within 24 hours after birth[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Pregnant rats[2]
Dosage: 30 μg/kg
Administration: p.o.; daily; gestational days 1-14
Result: Resulted in newborn pups that were lighter than normal and died within 24 hours postpartum.
Molecular Weight

494.57

Formula

C27H36F2O6
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

C[C@@]12[C@](C[C@@H](C)[C@]2(O)C(COC(C(C)(C)C)=O)=O)([H])[C@@]3([H])[C@@](F)([C@@]4(C([C@@H](F)C3)=CC(C=C4)=O)C)[C@@H](O)C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (101.10 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0220 mL 10.1098 mL 20.2196 mL
5 mM 0.4044 mL 2.0220 mL 4.0439 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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(per animal)

g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.17%

SDS (393 KB)

COA (253 KB) LCMS (113 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0220 mL 10.1098 mL 20.2196 mL 50.5490 mL
5 mM 0.4044 mL 2.0220 mL 4.0439 mL 10.1098 mL
10 mM 0.2022 mL 1.0110 mL 2.0220 mL 5.0549 mL
15 mM 0.1348 mL 0.6740 mL 1.3480 mL 3.3699 mL
20 mM 0.1011 mL 0.5055 mL 1.0110 mL 2.5274 mL
25 mM 0.0809 mL 0.4044 mL 0.8088 mL 2.0220 mL
30 mM 0.0674 mL 0.3370 mL 0.6740 mL 1.6850 mL
40 mM 0.0505 mL 0.2527 mL 0.5055 mL 1.2637 mL
50 mM 0.0404 mL 0.2022 mL 0.4044 mL 1.0110 mL
60 mM 0.0337 mL 0.1685 mL 0.3370 mL 0.8425 mL
80 mM 0.0253 mL 0.1264 mL 0.2527 mL 0.6319 mL
100 mM 0.0202 mL 0.1011 mL 0.2022 mL 0.5055 mL
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Flumethasone pivalate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Flumethasone pivalate2002-29-1Flumethasone 21-pivalateGlucocorticoid Receptorpsoriasisvaricelladermatitislichen planuseczemadogsratsvacciniaforeign body granulomatopical corticosteroidInhibitorinhibitorinhibit

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