2002-29-1
2002-29-1
Chemical Structure
Flumethasone pivalate
Synonym(s): Flumethasone 21-pivalate
- CAS No.: 2002-29-1
- Formula:C27H36F2O6
- Molecular Weight:494.57
IUPAC Name: 2-((6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl pivalate
InChIKey: JWRMHDSINXPDHB-OJAGFMMFSA-N
SMILES: C[C@@]12[C@](C[C@@H](C)[C@]2(O)C(COC(C(C)(C)C)=O)=O)([H])[C@@]3([H])[C@@](F)([C@@]4(C([C@@H](F)C3)=CC(C=C4)=O)C)[C@@H](O)C1
Biological Activity: Flumethasone pivalate (Flumethasone 21-pivalate) is a glucocorticoid and a topical corticosteroid with anti-inflammatory, antipruritic, and vasoconstrictive actions. Flumethasone pivalate inhibits foreign body granuloma formation. Flumethasone pivalate can be used for the researches of dermatitis, eczema, and psoriasis[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Flumethasone pivalate | 98.17% | Flumethasone pivalate (Flumethasone 21-pivalate) is a glucocorticoid and a topical corticosteroid with anti-inflammatory, antipruritic, and vasoconstrictive actions. Flumethasone pivalate inhibits foreign body granuloma formation. Flumethasone pivalate can be used for the researches of dermatitis, eczema, and psoriasis. | ||||||||||||||||||||
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Flumethasone pivalate (Standard) | ≥98% | Flumethasone pivalate (Flumethasone 21-pivalate) (Standard) is the analytical standard of Flumethasone pivalate (HY-107949). This product is intended for research and analytical applications. Flumethasone pivalate is a glucocorticoid and a topical corticosteroid with anti-inflammatory, antipruritic, and vasoconstrictive actions. Flumethasone pivalate inhibits foreign body granuloma formation. Flumethasone pivalate can be used for the researches of dermatitis, eczema, and psoriasis. | ||||||||||||||||||||
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Diflorasone diacetate | 99.86% | Diflorasone diacetate is an anti-inflammatory steroid compound used as locally or topically agent. Diflorasone diacetate is being used for skin disorders to control corticosteroid-responsive dermatoses. | ||||||||||||||||||||
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Halobetasol | 99.11% | Halobetasol (Ulobetasol) is a corticosteroid. Halobetasol can be used for research of severe localized psoriasis. | ||||||||||||||||||||
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Flumethasone 21-acetate | Flumethasone 21-acetate (Compound 35) is a type of steroid. Flumethasone 21-acetate has lipophilic properties. | |||||||||||||||||||||
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Betamethasone acetate (Standard) | ≥98% | Betamethasone acetate (Standard) is the analytical standard of Betamethasone acetate (HY-13570B). This product is intended for research and analytical applications. Betamethasone acetate is a glucocorticoid with prenatal application for preventing respiratory distress syndrome (RDS) in premature infants. Betamethasone acetate exhibits dose-dependent effects on somatic and brain development in offspring when administered prenatally to pregnant rats. Betamethasone acetate can be used for the study of antenatal intervention. | ||||||||||||||||||||
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Fluticasone 17β-carboxylic acid | Fluticasone 17β-carboxylic acid is an intermediate in the synthesis of the glucocorticosteroid Fluticasone propionate (HY-B0154). | |||||||||||||||||||||
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Dexamethasone acetate (Standard) | 99.76% | Dexamethasone acetate (Standard) (Dexamethasone 21-acetate (Standard)) is the analytical standard of Dexamethasone acetate (HY-14648A). This product is intended for research and analytical applications. Dexamethasone acetate (Dexamethasone 21-acetate) is the acetate form of the glucocorticoid Dexamethasone (HY-14648). Dexamethasone acetate has a longer duration of action than Dexamethasone. Dexamethasone acetate can accumulate at inflammatory sites, in mouse liver and mouse lung via nanostructured lipid carriers. Dexamethasone acetate can be used to prepare topical formulations for studies related to sensorineural hearing loss, γ-carrageenan-induced paw edema, chronic active hepatitis, pulmonary diseases, and inflammation after vitreoretinal surgery. | ||||||||||||||||||||
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Diflorasone (Standard) | ≥98% | Diflorasone (Standard) is the analytical standard of Diflorasone (HY-A0158). This product is intended for research and analytical applications. Diflorasone is a potent topical anti-inflammatory Corticosteroid. Diflorasone induces vasoconstriction when applied topically. Diflorasone can be used in research related to psoriasis, atopic dermatitis/neurodermatitis. | ||||||||||||||||||||
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Halobetasol propionate | 99.74% | Halobetasol propionate (BMY-30056) is a synthetic glucocorticoid corticosteroid. Halobetasol propionate exhibits anti-inflammatory, antipruritic, and vasoconstrictive properties. Halobetasol propionate can be used for the study of psoriasis. | ||||||||||||||||||||
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Flumethasone | 99.84% | Flumethasone (Flumetasone) is an orally active, high selective and potent glucocorticoid receptor (GR) agonist. Flumethasone activates GR to inhibit nuclear factor kappa B (NF-κB)-mediated pro-inflammatory cytokine production (TNF-α, IL-1β) and promotes anti-inflammatory gene expression (IL-10), while also regulating metabolic enzyme activity (tyrosine aminotransferase induction). Flumethasone is promising for research of inflammatory diseases, cancer, and endocrine regulation. | ||||||||||||||||||||
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Dexamethasone impurity 6 | Dexamethasone impurity 6 is an impurity of Dexamethasone. | |||||||||||||||||||||
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References
- [1]. Finley A G, et al. Flumethasone pivalate (" locacorten"), a new topical corticosteroid[J]. The Medical journal of Australia, 1965, 2(19): 787-790. [Content Brief]
- [2]. Ciba Pharmaceutical Company. Flumethasone pivalate (Locorten); Anti‐inflammatory, antipruritic[J]. Clinical Pharmacology & Therapeutics, 1970, 11(6): 927-929.
