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  4. EGTA tetrasodium

EGTA tetrasodium is a specific calcium ion chelator. EGTA tetrasodium has an apparent calcium dissociation constant (Kd) of 60.5 nM at physiological pH (7.4) and has very high specificity for Ca2+ over Mg2+ (Mg2+ Kd 1-10 mM). EGTA tetrasodium significantly inhibits the substrate adherence capacity of inflammatory macrophages.

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EGTA tetrasodium Chemical Structure

EGTA tetrasodium Chemical Structure

CAS No. : 13368-13-3

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EGTA tetrasodium Related Antibodies

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Description

EGTA tetrasodium is a specific calcium ion chelator. EGTA tetrasodium has an apparent calcium dissociation constant (Kd) of 60.5 nM at physiological pH (7.4) and has very high specificity for Ca2+ over Mg2+ (Mg2+ Kd 1-10 mM). EGTA tetrasodium significantly inhibits the substrate adherence capacity of inflammatory macrophages[1][2].

In Vitro

EGTA tetrasodium, proposed as endodontic irrigant, decreases substrate adherence capacity of inflammatory macrophages in a time- and dose-dependent manner. The EGTA tetrasodium concentration that causes an IC50 is 202 mM. Chelators react with calcium ions in the hydroxyapatite crystals to produce a metallic chelate. Removal of calcium ions from the dentine makes the dentinal tissue softer, especially the hydroxyapatite-rich peritubular dentin and increases the diameter of exposed dentinal tubules[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

EGTA tetrasodium Related Antibodies
Molecular Weight

468.28

Formula

C14H20N2Na4O10
CAS No.
SMILES

O=C(O[Na])CN(CC(O[Na])=O)CCOCCOCCN(CC(O[Na])=O)CC(O[Na])=O
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Room temperature in continental US; may vary elsewhere.
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EGTA tetrasodium Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGTA tetrasodium13368-13-3Biochemical Assay ReagentscalciumionchelatorendodonticirrigantinflammatorymacrophagesInhibitorinhibitorinhibit

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