13368-13-3
13368-13-3
Chemical Structure
EGTA tetrasodium
- CAS No.: 13368-13-3
- Formula:C14H20N2Na4O10
- Molecular Weight:468.28
IUPAC Name: sodium 3,12-bis(carboxylatomethyl)-6,9-dioxa-3,12-diazatetradecanedioate
InChIKey: BAOGCDPNNOBWQZ-UHFFFAOYSA-J
SMILES: O=C(O[Na])CN(CC(O[Na])=O)CCOCCOCCN(CC(O[Na])=O)CC(O[Na])=O
Biological Activity: EGTA tetrasodium is a cell-impermeant specific calcium ion chelator. EGTA tetrasodium has an apparent calcium dissociation constant (Kd) of 60.5 nM at physiological pH (7.4) and has very high specificity for Ca2+ over Mg2+ (Mg2+ Kd 1-10 mM). EGTA tetrasodium significantly inhibits the substrate adherence capacity of inflammatory macrophages[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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EGTA tetrasodium | 99.93% | EGTA tetrasodium is a cell-impermeant specific calcium ion chelator. EGTA tetrasodium has an apparent calcium dissociation constant (Kd) of 60.5 nM at physiological pH (7.4) and has very high specificity for Ca2+ over Mg2+ (Mg2+ Kd 1-10 mM). EGTA tetrasodium significantly inhibits the substrate adherence capacity of inflammatory macrophages. | ||||||||||||||||||||
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References
- [1]. Harris RA, Hanrahan JW. Effects of EGTA on calcium signaling in airway epithelial cells. Am J Physiol. 1994;267(5 Pt 1):C1426-C1434. doi:10.1152/ajpcell.1994.267.5.C1426. [Content Brief]
- [2]. Segura-Egea JJ, Jiménez-Rubio A, Rios-Santos JV, Velasco-Ortega E, Calvo-Gutierrez JR. In vitro inhibitory effect of EGTA on macrophage adhesion: endodontic implications. J Endod. 2003;29(3):211-213. [Content Brief]
