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  4. Ethylenediaminetetraacetic acid tetrasodium

Ethylenediaminetetraacetic acid tetrasodium  (Synonyms: EDTA tetrasodium)

Cat. No.: HY-Y0682B Purity: 98.0%
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Ethylenediaminetetraacetic acid (EDTA) tetrasodium is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium). Ethylenediaminetetraacetic acid tetrasodium has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. Ethylenediaminetetraacetic acid tetrasodium decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid tetrasodium can alleviate the liver fibrosis. Ethylenediaminetetraacetic acid tetrasodium can be used for coronary artery disease and neural system disease research.

For research use only. We do not sell to patients.

CAS No. : 64-02-8

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Based on 24 publication(s) in Google Scholar

Other Forms of Ethylenediaminetetraacetic acid tetrasodium:

Ethylenediaminetetraacetic acid tetrasodium Related Antibodies

Top Publications Citing Use of Products

    Ethylenediaminetetraacetic acid tetrasodium purchased from MedChemExpress. Usage Cited in: Nat Immunol. 2025 Oct;26(10):1660-1672.  [Abstract]

    Representative images of CHMP4–GFP puncta (arrowheads; left) and percentage of CHMP4 speckle+ (top right) or Annexin V+ (bottom right) cells in BMDMs incubated with PBS, 15 µM SK56, 2 mM EDTA or EDTA + SK56 at 2 h after the addition of 1 μg/ml LPS + 10 μM nigericin; scale bar, 50 µm; n = 5 repeats

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    Description

    Ethylenediaminetetraacetic acid (EDTA) tetrasodium is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium). Ethylenediaminetetraacetic acid tetrasodium has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. Ethylenediaminetetraacetic acid tetrasodium decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid tetrasodium can alleviate the liver fibrosis. Ethylenediaminetetraacetic acid tetrasodium can be used for coronary artery disease and neural system disease research[1][2][3][4][5][6][7].

    In Vitro

    Ethylenediaminetetraacetic acid has a strong bactericidal effect on the cell wall of P. aeruginosa and a. faecalis[4].
    Ethylenediaminetetraacetic acid (0.005-0.01 M) has good heavy metal extraction in contaminated silty-clay-loam soil columns, can extract Pb, Cd and Zn in a concentration-dependent way with an extraction efficiency sequence of Pb > Cd > Zn[6].
    Ethylenediaminetetraacetic acid (1.2 mM) enhances the activity of the CRE driving promoter by activating T-cell death-associated gene 8 (TDAG8) in HEK293T cells, thereby enhancing the production of cAMP in the cells[7].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Ethylenediaminetetraacetic acid tetrasodium Related Antibodies
    In Vivo

    Ethylenediaminetetraacetic acid (60 mg/kg; Intraperitoneal injection; Three times per week for three weeks) can reduce liver fibrosis, lipid peroxidation and liver inflammation in CCl4 induced liver fibrosis rats, and has antioxidant and anti-inflammatory activities[5].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Male Wistar rat model of cirrhosis induced by CCl4[5]
    Dosage: 60 mg/kg, 120 mg/kg, 240 mg/kg
    Administration: Intraperitoneal injection (i.p.); Three times per week for 3 weeks (during this period, CCl4 administration continued). After CCl4 and mineral oil mixture treatment (200 μL/mouse; i.p.; Three times per week for eight weeks).
    Result: Kept kept all the rats alive at the 60 mg/kg dose, but died at 120 and 240 mg/kg.
    Reduced fibrosis of the liver in surviving rats (20%).
    Animal Model: Male Wistar rat model of cirrhosis induced by CCl[5]
    Dosage: 60 mg/kg
    Administration: Intraperitoneal injection (i.p.); Three times per week for 11 weeks. (Preventive Ethylenediaminetetraacetic acid (EDTA) group: EDTA and CCl4 were administered during 11 weeks, three times per week on alternate days).
    Intraperitoneal injection (i.p.); Three times per week. After CCl4 treatment (i.p.; Three times per week for eight weeks) (Therapeutic EDTA group: EDTA and CCl4 were administered for 3 weeks, three times per week on alternate days).
    Result: Increased sod activity by 50% in the preventive EDTA group. (Compared with untreated EDTA group)
    Increased Cp activity in the preventive EDTA (30%) and therapeutic EDTA (20%) groups. (Compared with the fibrotic group)
    Decreased mRNA expression of the pro-inflammatory molecule (TNF-α and LI-6) and the profibrogenic molecules (TGF-β and αCOLI) in both the prevention and treatment groups.
    Molecular Weight

    380.17

    Formula

    C10H12N2Na4O8
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=C(O[Na])CN(CCN(CC(O[Na])=O)CC(O[Na])=O)CC(O[Na])=O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    H2O : 125 mg/mL (328.80 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.6304 mL 13.1520 mL 26.3040 mL
    5 mM 0.5261 mL 2.6304 mL 5.2608 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    (per animal)

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 98.0%

    SDS (793 KB)

    COA (254 KB) HNMR (253 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 2.6304 mL 13.1520 mL 26.3040 mL 65.7601 mL
    5 mM 0.5261 mL 2.6304 mL 5.2608 mL 13.1520 mL
    10 mM 0.2630 mL 1.3152 mL 2.6304 mL 6.5760 mL
    15 mM 0.1754 mL 0.8768 mL 1.7536 mL 4.3840 mL
    20 mM 0.1315 mL 0.6576 mL 1.3152 mL 3.2880 mL
    25 mM 0.1052 mL 0.5261 mL 1.0522 mL 2.6304 mL
    30 mM 0.0877 mL 0.4384 mL 0.8768 mL 2.1920 mL
    40 mM 0.0658 mL 0.3288 mL 0.6576 mL 1.6440 mL
    50 mM 0.0526 mL 0.2630 mL 0.5261 mL 1.3152 mL
    60 mM 0.0438 mL 0.2192 mL 0.4384 mL 1.0960 mL
    80 mM 0.0329 mL 0.1644 mL 0.3288 mL 0.8220 mL
    100 mM 0.0263 mL 0.1315 mL 0.2630 mL 0.6576 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Ethylenediaminetetraacetic acid tetrasodium Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Ethylenediaminetetraacetic acid tetrasodium64-02-8EDTA tetrasodiumSODBiochemical Assay ReagentsEnvironmental PollutantsBacterialSuperoxide DismutaseEnvironmental ContaminantsAnticoagulantAnti-hypercalcemicProtein purificationProtein storageHEK293TTDAG8cAMPChelating agentHypercalcemiaHepatic fibrosisInhibitorinhibitorinhibit

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