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  4. Ethylenediaminetetraacetic acid tetrasodium

Ethylenediaminetetraacetic acid tetrasodium  (Synonyms: EDTA tetrasodium)

Cat. No.: HY-Y0682B Purity: ≥98.0%
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Ethylenediaminetetraacetic acid (EDTA) tetrasodium is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium). Ethylenediaminetetraacetic acid tetrasodium has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. Ethylenediaminetetraacetic acid tetrasodium decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid tetrasodium can alleviate the liver fibrosis. Ethylenediaminetetraacetic acid tetrasodium can be used for coronary artery disease and neural system disease research.

For research use only. We do not sell to patients.

Ethylenediaminetetraacetic acid tetrasodium Chemical Structure

Ethylenediaminetetraacetic acid tetrasodium Chemical Structure

CAS No. : 64-02-8

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Based on 5 publication(s) in Google Scholar

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Ethylenediaminetetraacetic acid tetrasodium Related Antibodies

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Description

Ethylenediaminetetraacetic acid (EDTA) tetrasodium is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium). Ethylenediaminetetraacetic acid tetrasodium has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. Ethylenediaminetetraacetic acid tetrasodium decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid tetrasodium can alleviate the liver fibrosis. Ethylenediaminetetraacetic acid tetrasodium can be used for coronary artery disease and neural system disease research[1][2][3][4][5][6][7].

In Vitro

Ethylenediaminetetraacetic acid has a strong bactericidal effect on the cell wall of P. aeruginosa and a. faecalis[4].
Ethylenediaminetetraacetic acid (0.005-0.01 M) has good heavy metal extraction in contaminated silty-clay-loam soil columns, can extract Pb, Cd and Zn in a concentration-dependent way with an extraction efficiency sequence of Pb > Cd > Zn[6].
Ethylenediaminetetraacetic acid (1.2 mM) enhances the activity of the CRE driving promoter by activating T-cell death-associated gene 8 (TDAG8) in HEK293T cells, thereby enhancing the production of cAMP in the cells[7].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ethylenediaminetetraacetic acid tetrasodium Related Antibodies
In Vivo

Ethylenediaminetetraacetic acid (60 mg/kg; Intraperitoneal injection; Three times per week for three weeks) can reduce liver fibrosis, lipid peroxidation and liver inflammation in CCl4 induced liver fibrosis rats, and has antioxidant and anti-inflammatory activities[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rat model of cirrhosis induced by CCl4[5]
Dosage: 60 mg/kg, 120 mg/kg, 240 mg/kg
Administration: Intraperitoneal injection (i.p.); Three times per week for 3 weeks (during this period, CCl4 administration continued). After CCl4 and mineral oil mixture treatment (200 μL/mouse; i.p.; Three times per week for eight weeks).
Result: Kept kept all the rats alive at the 60 mg/kg dose, but died at 120 and 240 mg/kg.
Reduced fibrosis of the liver in surviving rats (20%).
Animal Model: Male Wistar rat model of cirrhosis induced by CCl[5]
Dosage: 60 mg/kg
Administration: Intraperitoneal injection (i.p.); Three times per week for 11 weeks. (Preventive Ethylenediaminetetraacetic acid (EDTA) group: EDTA and CCl4 were administered during 11 weeks, three times per week on alternate days).
Intraperitoneal injection (i.p.); Three times per week. After CCl4 treatment (i.p.; Three times per week for eight weeks) (Therapeutic EDTA group: EDTA and CCl4 were administered for 3 weeks, three times per week on alternate days).
Result: Increased sod activity by 50% in the preventive EDTA group. (Compared with untreated EDTA group)
Increased Cp activity in the preventive EDTA (30%) and therapeutic EDTA (20%) groups. (Compared with the fibrotic group)
Decreased mRNA expression of the pro-inflammatory molecule (TNF-α and LI-6) and the profibrogenic molecules (TGF-β and αCOLI) in both the prevention and treatment groups.
Clinical Trial
Molecular Weight

380.17

Formula

C10H12N2Na4O8
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[Na].O=C(O)CN(CC(=O)O)CCN(CC(=O)O)CC(=O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 125 mg/mL (328.80 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6304 mL 13.1520 mL 26.3040 mL
5 mM 0.5261 mL 2.6304 mL 5.2608 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

COA (254 KB) HNMR (250 KB) MS (68 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.6304 mL 13.1520 mL 26.3040 mL 65.7601 mL
5 mM 0.5261 mL 2.6304 mL 5.2608 mL 13.1520 mL
10 mM 0.2630 mL 1.3152 mL 2.6304 mL 6.5760 mL
15 mM 0.1754 mL 0.8768 mL 1.7536 mL 4.3840 mL
20 mM 0.1315 mL 0.6576 mL 1.3152 mL 3.2880 mL
25 mM 0.1052 mL 0.5261 mL 1.0522 mL 2.6304 mL
30 mM 0.0877 mL 0.4384 mL 0.8768 mL 2.1920 mL
40 mM 0.0658 mL 0.3288 mL 0.6576 mL 1.6440 mL
50 mM 0.0526 mL 0.2630 mL 0.5261 mL 1.3152 mL
60 mM 0.0438 mL 0.2192 mL 0.4384 mL 1.0960 mL
80 mM 0.0329 mL 0.1644 mL 0.3288 mL 0.8220 mL
100 mM 0.0263 mL 0.1315 mL 0.2630 mL 0.6576 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ethylenediaminetetraacetic acid tetrasodium64-02-8EDTA tetrasodiumBiochemical Assay ReagentsBacterialSODSuperoxide DismutaseAnticoagulantAnti-hypercalcemicProtein purificationProtein storageHEK293T，TDAG8，cAMPChelating agentHypercalcemiaHepatic fibrosisInhibitorinhibitorinhibit

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