1. Apoptosis
  2. Apoptosis
  3. CLEFMA

CLEFMA 

Cat. No.: HY-136718
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CLEFMA is a curcuminoid with antitumor activity. CLEFMA inhibits tumor growth is associated with NF-κB-regulated anti-inflammatory and anti-metastatic effects.

For research use only. We do not sell to patients.

CLEFMA Chemical Structure

CLEFMA Chemical Structure

CAS No. : 1246964-32-8

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Description

CLEFMA is a curcuminoid with antitumor activity. CLEFMA inhibits tumor growth is associated with NF-κB-regulated anti-inflammatory and anti-metastatic effects[1][2].

In Vitro

CLEFMA (1-100 μM; 24-72 h) has anti-proliferative activity[1].
CLEFMA inhibits the viability of H441 and A549 cells, with IC50s of 6.4 and 8.9 μM, respectively[2].
CLEFMA (5-10 μM; 24 h) induces apoptosis in H441 and A549 cells[2].
CLEFMA (1 and 10 μM; 24 h) induces autophagic death in H441 cells[1].
CLEFMA (1-20 μM) reduces the DNA-binding activity of NF-κB in H441 cells in a dose-dependent manner[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: PANC-1, MiaPaCa-2, PC-3 and H441 cells
Concentration: 1, 10, 25, 100 μM
Incubation Time: 24, 48, 72 h
Result: Inhibits cells proliferation in a dose-dependent manner.
In Vivo

CLEFMA (0.2-0.4 mg/kg; i.p. daily for 4 weeks) inhibits tumor growth and suppresses the uptake of FDG in tumor tissue in a xenograft mouse model[2].
CLEFMA (0.2-0.4 mg/kg; i.p. daily for 4 weeks) down-regulates the expression of anti-apoptotic markers cIAP1, Bcl-xL, Bcl-2 and survivin, and induces the cleavage of pro-apoptotic protein BID and the expression of pro-apoptotic BAX in tumor tissue[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male athymic nu/nu mice (4 weeks old) are injected H441 cells[2]
Dosage: 0.2, 0.4 mg/kg
Administration: I.p. daily for 4 weeks
Result: Inhibited tumor growth up to 96% tumor at dose of 0.4 mg/kg.
Molecular Weight

442.29

Formula

C₂₃H₁₇Cl₂NO₄

CAS No.

1246964-32-8

SMILES

O=C(O)/C=C\C(N1C/C(C(/C(C1)=C/C2=CC=CC=C2Cl)=O)=C\C3=CC=CC=C3Cl)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

CLEFMAApoptosiscurcuminoid antitumorNF-κB-regulatedanti-inflammatoryanti-metastaticcancerInhibitorinhibitorinhibit

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