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  3. CLEFMA

CLEFMA is a curcuminoid with antitumor activity. CLEFMA inhibits tumor growth is associated with NF-κB-regulated anti-inflammatory and anti-metastatic effects.

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CLEFMA Chemical Structure

CLEFMA Chemical Structure

CAS No. : 1246964-32-8

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Description

CLEFMA is a curcuminoid with antitumor activity. CLEFMA inhibits tumor growth is associated with NF-κB-regulated anti-inflammatory and anti-metastatic effects[1][2].

In Vitro

CLEFMA (1-100 μM; 24-72 h) has anti-proliferative activity[1].
CLEFMA inhibits the viability of H441 and A549 cells, with IC50s of 6.4 and 8.9 μM, respectively[2].
CLEFMA (5-10 μM; 24 h) induces apoptosis in H441 and A549 cells[2].
CLEFMA (1 and 10 μM; 24 h) induces autophagic death in H441 cells[1].
CLEFMA (1-20 μM) reduces the DNA-binding activity of NF-κB in H441 cells in a dose-dependent manner[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: PANC-1, MiaPaCa-2, PC-3 and H441 cells
Concentration: 1, 10, 25, 100 μM
Incubation Time: 24, 48, 72 h
Result: Inhibits cells proliferation in a dose-dependent manner.
In Vivo

CLEFMA (0.2-0.4 mg/kg; i.p. daily for 4 weeks) inhibits tumor growth and suppresses the uptake of FDG in tumor tissue in a xenograft mouse model[2].
CLEFMA (0.2-0.4 mg/kg; i.p. daily for 4 weeks) down-regulates the expression of anti-apoptotic markers cIAP1, Bcl-xL, Bcl-2 and survivin, and induces the cleavage of pro-apoptotic protein BID and the expression of pro-apoptotic BAX in tumor tissue[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male athymic nu/nu mice (4 weeks old) are injected H441 cells[2]
Dosage: 0.2, 0.4 mg/kg
Administration: I.p. daily for 4 weeks
Result: Inhibited tumor growth up to 96% tumor at dose of 0.4 mg/kg.
Molecular Weight

442.29

Formula

C23H17Cl2NO4

CAS No.
SMILES

O=C(O)/C=C\C(N1C/C(C(/C(C1)=C/C2=CC=CC=C2Cl)=O)=C\C3=CC=CC=C3Cl)=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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CLEFMA Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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CLEFMA
Cat. No.:
HY-136718
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