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SU0268 

Cat. No.: HY-139056
Handling Instructions

SU0268 is a potent and specific inhibitor of 8-Oxoguanine DNA glycosylase 1 (OGG1). SU0268 regulates inflammatory responses during Pseudomonas aeruginosa infection.

For research use only. We do not sell to patients.

SU0268 Chemical Structure

SU0268 Chemical Structure

CAS No. : 2210228-45-6

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Description

SU0268 is a potent and specific inhibitor of 8-Oxoguanine DNA glycosylase 1 (OGG1). SU0268 regulates inflammatory responses during Pseudomonas aeruginosa infection[1][2][3].

In Vitro

MTH1-depleted cells are less sensitive to the OGG1-specific inhibitor, SU0268 (5-10 μM), than their control shGFP counterparts[1].
SU0268/IACS-4759 (5-20 μM, 48h) co-treated cells are more viable than the correspondingly-treated IACS-4759- or SU0268-treated cells[1].
SU0268 does not bind DNA and thus interacts with OGG1 specifically rather than its substrate[2].
SU0268 induces the release of type I IFN by the mitochondrial DNA-cGAS-STING-IRF3-IFN-β axis, which decreases bacterial loads and halts disease progression[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: A549 shGFP and shMTH1 (2000 cells per well).
Concentration: 0.1 μM, 0.5 μM, 1 μM, 2.5 μM, 5 μM, 7.5 μM, 10 μM.
Incubation Time: 24 or 48 h.
Result: The shGFP cells were more susceptible to OGG1 inhibition via increasing SU0268 doses than the shMTH1 cells, especially at the 48 time-point.
In Vivo

SU0268 pretreatment (10 mg/kg, intranasally treated) increases survival rates compared with controls without SU0268 pretreatment in MH-S cells and C57BL/6N mice[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Anesthetized C57BL/6N mice[3].
Dosage: 10 mg/kg.
Administration: Intranasally treated.
Result: Significantly inhibits inflammatory responses and mitigates P. aeruginosa infection.
Molecular Weight

475.56

Formula

C₂₆H₂₅N₃O₄S

CAS No.
SMILES

O=C(C1=CC(C2=CC=C(S(=O)(NC3=CC4=C(C=C3)CCCN4C(C5CC5)=O)=O)C=C2)=CC=C1)N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

SU0268SU 0268SU-0268OthersOGG1glycosylaseA549MCF-7HeLaantibacterialcGASSTINGIRF3Inhibitorinhibitorinhibit

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