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glycosylase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Bacterial (1)
By Research Areas:	Cancer (4) Infection (2) Inflammation/Immunology (3) Metabolic Disease (1)

7

Inhibitors & Agonists

5

Recombinant Proteins

2

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

OGG1-IN-08 1 Publications Verification	Others	Inflammation/Immunology
OGG1-IN-08 is a potent *8-oxoguanine DNA glycosylase-1 (OGG1)* inhibitor with an IC₅₀ value of 0.22 μM. OGG1-IN-08 decreases both the glycosylase and lyase activities of OGG1 .

SU0268 1 Publications Verification	Others	Infection Inflammation/Immunology Cancer
SU0268 is a potent and specific inhibitor of *8-Oxoguanine DNA glycosylase* 1 (OGG1)*. SU0268 regulates inflammatory responses during Pseudomonas aeruginosa* infection .

TH10785	Others	Metabolic Disease Cancer
TH10785 is a *DNA glycosylase* 1 (OGG1)** activator, TH10785 can interact with the phenylalanine-319 and glycine-42 amino acids of OGG1 and increase the enzyme activity, generates β, δ-lyase enzymatic function. TH10785 can control the catalytic activity mediated by a nitrogen base within its molecular structure. TH10785 can be used for the research of various diseases and aging connected with DNA oxidative lesions .

*Uracil DNA Glycosylase* (UDG/UNG), heat-sensitive** Heat-sensitive UDG	Others	Cancer
Uracil DNA Glycosylase (UDG/UNG), heat-sensitive (Heat-sensitive UDG) can catalyze the hydrolysis of the N-glycosidic bond between the uracil base and the sugar phosphate backbone in the DNA chain containing uracil, releasing free uracil. Uracil DNA Glycosylase (UDG/UNG), heat-sensitive eliminates the carryover contamination dUTP-incorporated amplification products .

MtUng-IN-1	Bacterial	Infection Cancer
MtUng-IN-1 (Compound 18a) is a Uracil DNA glycosylase of Mycobacterium (MtUng) inhibitor (IC₅₀: 300 μM). MtUng-IN-1 can be used for research of cancers and infectious diseases .

TH5487 Maximum Cited Publications 7 Publications Verification	Others	Inflammation/Immunology
TH5487 is a potent 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor with an IC₅₀ of 342 nM. TH5487 stops OGG1 from recognizing its DNA substrate, inhibits DNA repair and modifies OGG1 chromatin dynamics, which results in the inhibition of proinflammatory pathway genes .

Methoxyamine hydrochloride O-Methylhydroxylamine hydrochloride
Methoxyamine (O-Methylhydroxylamine) hydrochloride is an orally active and potent base excision repair (BER) inhibitor. Methoxyamine hydrochloride binds to 3’ hydroxyl groups that are left behind by 3-methylpurine-DNA glycosylase (MPG) following excision of the damaged base and thus inhibits BER activity. Methoxyamine hydrochloride binds directly to the apyrimidinic (AP) sites. Methoxyamine hydrochloride synergistically enhances the therapeutic efficacy of DNA-damaging agents .

Species:	Human (5)
Tag:	His (3) SUMO (1) Tag Free (1) GST (1)
Source:	E. coli (5)

Cat. No.	Compare	Product Name	Species	Source

	OGG1 Protein, Human (His) 8-oxoguanine DNA glycosylase; 8-hydroxyguanine DNA glycosylase; MMH; MUTM; OGH1	Human	E. coli
	The OGG1 protein is a DNA repair enzyme specifically designed to cleave DNA at the 8-oxoG residue and plays a key role in maintaining genome integrity. It demonstrates the ability to excise damaged bases such as 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine from the DNA structure (FAPY). OGG1 Protein, Human (His) is the recombinant human-derived OGG1 protein, expressed by E. coli , with C-6*His labeled tag. The total length of OGG1 Protein, Human (His) is 344 a.a., with molecular weight of ~38.7 kDa.

	OGG1 Protein, Human (N-His) 8-oxoguanine DNA glycosylase; 8-hydroxyguanine DNA glycosylase; MMH; MUTM; OGH1	Human	E. coli
	The OGG1 protein is a DNA repair enzyme specifically designed to cleave DNA at the 8-oxoG residue and plays a key role in maintaining genome integrity. It demonstrates the ability to excise damaged bases such as 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine from the DNA structure (FAPY). OGG1 Protein, Human (N-His) is the recombinant human-derived OGG1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of OGG1 Protein, Human (N-His) is 344 a.a., with molecular weight of ~38.7 kDa.

	SMUG1 Protein, Human (His-SUMO) FDG; HMUDG; MGC104370; Single strand selective monofunctional uracil DNA glycosylase 1; Single strand selective monofunctional uracil DNA glycosylase; Single-strand selective monofunctional uracil DNA glycosylase; SMUG 1; Smug1; SMUG1 protein; SMUG1_HUMAN; UNG 3; UNG3	Human	E. coli
	SMUG1 protein is a single-function DNA glycosylase that plays a crucial role in base excision DNA repair, especially the recognition and repair of uracil (U) residues, preferentially recognizing mismatches (U/G) rather than matching (U/A). Its activity extends to the excision of 5-formyluracil (fU), 5-hydroxyuracil (hoU) and 5-hydroxymethyluracil (hmU) in single-stranded (ssDNA) and double-stranded DNA (dsDNA). SMUG1 Protein, Human (His-SUMO) is the recombinant human-derived SMUG1 protein, expressed by E. coli , with N-His, N-SUMO labeled tag. The total length of SMUG1 Protein, Human (His-SUMO) is 177 a.a., with molecular weight of ~35.6 kDa.

	OGG1 Protein, Human N-glycosylase/DNA Lyase; 8-Oxoguanine DNA glycosylase; DNA-(Apurinic or Apyrimidinic Site) Lyase; AP Lyase; OGG1; MMH; MUTM; OGH1	Human	E. coli
	The OGG1 protein is a DNA repair enzyme specifically designed to cleave DNA at the 8-oxoG residue and plays a key role in maintaining genome integrity. It demonstrates the ability to excise damaged bases such as 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine from the DNA structure (FAPY). OGG1 Protein, Human (GST) is the recombinant human-derived OGG1 protein, expressed by E. coli , with tag free. The total length of OGG1 Protein, Human (GST) is 345 a.a., with molecular weight of ~38.0 kDa.

	UNG Protein, Human (His) Uracil-DNA glycosylase; UDG; DGU; UNG1	Human	E. coli
	UNG Protein excises uracil residues from DNA, addressing misincorporation of dUMP by DNA polymerase or cytosine deamination. UNG Protein, Human (His) is the recombinant human-derived UNG protein, expressed by E. coli , with N-His labeled tag. The total length of UNG Protein, Human (His) is 220 a.a., with molecular weight of ~26 kDa.

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