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OGG1-IN-08 

Cat. No.: HY-112902
Handling Instructions

OGG1-IN-08 is a potent 8-oxoguanine DNA glycosylase-1 (OGG1) inhibitor with an IC50 value of 0.22 μM. OGG1-IN-08 decreases both the glycosylase and lyase activities of OGG1.

For research use only. We do not sell to patients.

OGG1-IN-08 Chemical Structure

OGG1-IN-08 Chemical Structure

CAS No. : 350997-39-6

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Description

OGG1-IN-08 is a potent 8-oxoguanine DNA glycosylase-1 (OGG1) inhibitor with an IC50 value of 0.22 μM. OGG1-IN-08 decreases both the glycosylase and lyase activities of OGG1[1].

IC50 & Target

IC50: 0.22 μM (OGG1)[1]

In Vitro

OGG1-IN-08 (50 μM) inhibits different DNA glycosylases activities, it inhibits nei endonuclease VIII-like 1 DNA glycosylase (NEIL1)(84.56%), endonuclease III-like (NTH1)(63.09%), and Fpg (91.74%), respectively[1].
OGG1-IN-08 (10 μM) has a inhibitory OGG1 lyase activity on a substrate containing an AP site compared with the no inhibitor control[1].
OGG1-IN-08 (10 μM) decreases the number of bases released into solution by OGG1 for both the 8-oxo-Gua and FapyGua compared with the no inhibitor[1].

Molecular Weight

261.13

Formula

C₉H₆Cl₂N₂OS

CAS No.

350997-39-6

SMILES

O=C(C1=C(Cl)C2=C(Cl)C=CC=C2S1)NN

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

OGG1-IN-08OthersglycosylaselyaseOGG1AP site8-oxo-GuaFapyGuaInhibitorinhibitorinhibit

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