OGG1-IN-08
Based on 2 publication(s) in Google Scholar
OGG1-IN-08 is a potent 8-oxoguanine DNA glycosylase-1 (OGG1) inhibitor with an IC50 value of 0.22 μM. OGG1-IN-08 decreases both the glycosylase and lyase activities of OGG1.
For research use only. We do not sell to patients.
- Purity: 99.18%
- CAS No.: 350997-39-6
- Formula: C9H6Cl2N2OS
- Molecular Weight:261.13
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) OGG1-IN-08
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Biological Activity
IC50: 0.22 μM (OGG1)[1]
OGG1-IN-08 (50 μM) inhibits different DNA glycosylases activities, it inhibits nei endonuclease VIII-like 1 DNA glycosylase (NEIL1)(84.56%), endonuclease III-like (NTH1)(63.09%), and Fpg (91.74%), respectively[1].OGG1-IN-08 (10 μM) has a inhibitory OGG1 lyase activity on a substrate containing an AP site compared with the no inhibitor control[1].OGG1-IN-08 (10 μM) decreases the number of bases released into solution by OGG1 for both the 8-oxo-Gua and FapyGua compared with the no inhibitor[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 350997-39-6
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Appearance Solid
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Molecular Weight 261.13
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Formula C9H6Cl2N2OS
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Color White to yellow
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SMILES
O=C(C1=C(Cl)C2=C(Cl)C=CC=C2S1)NN
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
Solvent & Solubility
DMSO : 25 mg/mL (95.74 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (7.97 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (275 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.8295 mL | 19.1476 mL | 38.2951 mL | 95.7378 mL |
| 5 mM | 0.7659 mL | 3.8295 mL | 7.6590 mL | 19.1476 mL | |
| 10 mM | 0.3830 mL | 1.9148 mL | 3.8295 mL | 9.5738 mL | |
| 15 mM | 0.2553 mL | 1.2765 mL | 2.5530 mL | 6.3825 mL | |
| 20 mM | 0.1915 mL | 0.9574 mL | 1.9148 mL | 4.7869 mL | |
| 25 mM | 0.1532 mL | 0.7659 mL | 1.5318 mL | 3.8295 mL | |
| 30 mM | 0.1277 mL | 0.6383 mL | 1.2765 mL | 3.1913 mL | |
| 40 mM | 0.0957 mL | 0.4787 mL | 0.9574 mL | 2.3934 mL | |
| 50 mM | 0.0766 mL | 0.3830 mL | 0.7659 mL | 1.9148 mL | |
| 60 mM | 0.0638 mL | 0.3191 mL | 0.6383 mL | 1.5956 mL | |
| 80 mM | 0.0479 mL | 0.2393 mL | 0.4787 mL | 1.1967 mL |
OGG1-IN-08 Related Classifications
HY-112902 Related Classifications
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