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OGG1 Antibody (YA3356)

(Synonyms: 8 hydroxyguanine DNA glycosylase; AP lyase; HMMH; HOGG1; MMH; MUTM; N glycosylase; Ogg1; OGH 1)
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Based on 1 publication(s) in Google Scholar

OGG1 Antibody (YA3356) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to OGG1.

For research use only. We do not sell to patients.
  • Host:

    Rabbit

  • Isotype:

    IgG

  • Application:

    WB

  • Reactivity :

    Human

  • Formulation:

    Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.

  • Conjugation:
    Non-conjugated
  • Experimental Validation Results for OGG1 Antibody (YA3356)
  • OGG1 Antibody (YA3356) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Applications

Application
WB Info
WB: Western Blot
Dilution Ratio 1:500-1:1000

Product Details

Description

OGG1 Antibody (YA3356) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to OGG1.

  • Host Rabbit
  • Clonality Recombinant, Monoclonal
  • Species Reactivity
    Human
  • Observed Molecular Weight
    Observed band size: 39 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 39 kDa
Species Reactivity Database

Entrez Gene: 4968 Human

SwissProt: O15527 Human

Immunogen

A synthesized peptide derived from human OGG1 aa300-345/345.

Sensitivity

Endogenous

Purification

Affinity Chromatography

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

RRID

AB_3105718

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.

  • Concentration

    Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Verification Images

  • Experimental Validation Results for OGG1 Antibody (YA3356)
    Western blot analysis of extracts from HepG2 (lane 2(20μg) and HepG2 (lane 3(40μg) using OGG1 (HY-P83611) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

Background

  • Function

    OGG1 is a DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion

  • Subcellular Localization

    Nucleus, nucleoplasm; Nucleus speckle; Nucleus matrix; Nucleus; Mitochondrion

  • Expression


    Tissue_specificity:Ubiquitous

  • Isoforms & Post-Translational Modification

    O15527 has 8 isomers: O15527-1: 38782 Da (predicted); O15527-2: 36433 Da (predicted); O15527-3: 45761 Da (predicted); O15527-4: 47237 Da (predicted); O15527-5: 39729 Da (predicted); O15527-6: 22210 Da (predicted); O15527-7: 40095 Da (predicted); O15527-8: 36085 Da (predicted).

  • SwissProt ID

    O15527

  • Gene ID
    4968 [NCBI]
  • Synonyms

    8 hydroxyguanine DNA glycosylase; AP lyase; HMMH; HOGG1; MMH; MUTM; N glycosylase; Ogg1; OGH 1

  • Research Field

    Epigenetics and Nuclear Signaling

OGG1 Antibody (YA3356) Related Classifications

MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
  • 1/16

    MedChemExpress Validation
     Western blot analysis of extracts from HepG2 (lane 2(20μg) and HepG2 (lane 3(40μg) using OGG1 (HY-P83611) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

  • OGG1 Antibody (YA3356) Product Image
    1/16
  • Experimental Validation Results for OGG1 Antibody (YA3356)
  • OGG1 Antibody (YA3356) Product Image
  • Experimental Validation Results for OGG1 Antibody (YA3356)
    1/1
    MedChemExpress Validation
     Western blot analysis of extracts from HepG2 (lane 2(20μg) and HepG2 (lane 3(40μg) using OGG1 (HY-P83611) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
  • Experimental Validation Results for OGG1 Antibody (YA3356)
  • OGG1 Antibody (YA3356) Product Image
    MedChemExpress Validation

    Western blot analysis of extracts from HepG2 (lane 2(20μg) and HepG2 (lane 3(40μg) using OGG1 (HY-P83611) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

  • OGG1 Antibody (YA3356) Product Image WB