OGG1 Protein, Human (N-His)
Based on 1 Customer Validation
The OGG1 protein is a DNA repair enzyme specifically designed to cleave DNA at the 8-oxoG residue and plays a key role in maintaining genome integrity.It demonstrates the ability to excise damaged bases such as 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine from the DNA structure (FAPY).OGG1 Protein, Human (N-His) is the recombinant human-derived OGG1 protein, expressed by E.coli , with N-6*His labeled tag.
- Species: Human
- Source: E. coli
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
The OGG1 protein is a DNA repair enzyme specifically designed to cleave DNA at the 8-oxoG residue and plays a key role in maintaining genome integrity.It demonstrates the ability to excise damaged bases such as 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine from the DNA structure (FAPY).OGG1 Protein, Human (N-His) is the recombinant human-derived OGG1 protein, expressed by E.coli , with N-6*His labeled tag.
OGG1 (8-Oxoguanine DNA Glycosylase 1) is a DNA repair enzyme crucial for maintaining genomic integrity. Specializing in the repair of oxidative DNA damage, OGG1 specifically incises DNA at 8-oxoG (8-oxoguanine) residues. Additionally, it excises other oxidatively damaged bases, such as 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY), contributing to the removal of mutagenic lesions from the DNA. Notably, OGG1 possesses a beta-lyase activity, enabling it to nick the DNA strand 3' to the lesion, initiating the repair process. This enzymatic versatility highlights OGG1's critical role in safeguarding the genome by counteracting the detrimental effects of oxidative stress on DNA integrity.
Technical Parameters
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Species Human
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Source E. coli
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Tag N-6*His
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Accession
O15527-1 (P2-G345)
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Gene ID4968
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Molecular Construction
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N-term
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6*His
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OGG1 (P2-G345)
Accession # O15527-1 -
C-term
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Protein Length
Full Length of Isoform-1
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Synonyms
OGG1; DNA-(Apurinic Or Apyrimidinic Site) Lyase; 8-Oxoguanine DNA Glycosylase; DNA-Apurinic Or Apyrimidinic Site Lyase; OGH1; OGG1 Type 1e; MUTM; OGG1 Type 1d; N-Glycosylase/DNA Lyase; OGG1 Type 1g; HOGG1; OGG1 Type 1h; HMMH; OGG1 Type 1f; 8-Hydroxyguanin
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AA Sequence
PARALLPRRMGHRTLASTPALWASIPCPRSELRLDLVLPSGQSFRWREQSPAHWSGVLADQVWTLTQTEEQLHCTVYRGDKSQASRPTPDELEAVRKYFQLDVTLAQLYHHWGSVDSHFQEVAQKFQGVRLLRQDPIECLFSFICSSNNNIARITGMVERLCQAFGPRLIQLDDVTYHGFPSLQALAGPEVEAHLRKLGLGYRARYVSASARAILEEQGGLAWLQQLRESSYEEAHKALCILPGVGTKVADCICLMALDKPQAVPVDVHMWHIAQRDYSWHPTTSQAKGPSPQTNKELGNFFRSLWGPYAGWAQAVLFSADLRQSRHAQEPPAKRRKGSKGPEG
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Predicted Molecular Mass
38.6 kDa
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Molecular Weight
Approximately 39 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Solution
Supplied as a 0.22 μm filtered solution of PBS, pH 7.4, 40% glycerol.
<1 EU/μg, determined by LAL method.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
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Data Sheet (236 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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