Anti-inflammatory agent 69
Anti-inflammatory agent 69 (compound 12), sesquiterpenoid, is an anti-inflammatory agent isolated from the dried flower buds of Tussilago farfara. Anti-inflammatory agent 69 can inhibit the NO production with IC50 value of 24 μM.
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- No. CAS: 80514-14-3
- Fòrmula: C26H38O5
- Peso molecular:430.58
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
Descripciòn
IC50 & Target
IC50: 24 μM (inhibit the NO production in LPS-activated RAW264.7 cells)[1]
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| MCF7 | IC50 |
11.9 μM
Compound: 8
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Antiproliferative activity against human MCF7 cells by MTT assay
Antiproliferative activity against human MCF7 cells by MTT assay
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[PMID: 32881525] |
| MDA-MB-231 | IC50 |
6.7 μM
Compound: 8
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Antiproliferative activity against human MDA-MB-231 cells by MTT assay
Antiproliferative activity against human MDA-MB-231 cells by MTT assay
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[PMID: 32881525] |
Chemical Information
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No. CAS 80514-14-3
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Peso molecular 430.58
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Fòrmula C26H38O5
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SMILES
CC/C(C)=C/C(O[C@H](C[C@@H](C(C)C)[C@]/12[H])C([C@]2([H])[C@H](OC(C(C)CC)=O)C(C1=C/C)=O)=C)=O
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Structure Classification
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocolo
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
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Research Protocol for Inflammation-related Diseases
The NLRP3 inflammasome is a cytosolic innate immune signaling platform that integrates priming signals and danger-signal activation to promote caspase-1 activation, maturation of IL-1β and IL-18, and gasdermin D-mediated pyroptotic cell death. The core experimental logic is to determine whether inflammatory disease phenotypes are driven by increased NLRP3 expression, ASC-containing inflammasome assembly, caspase-1 cleavage, GSDMD cleavage, and extracellular release of IL-1β/IL-18 rather than by nonspecific cell injury alone. The pathway is strongly linked to inflammation-related disease phenotypes because monosodium urate crystals activate NALP3/NLRP3 inflammasome signaling in gout-like crystal inflammation, cholesterol crystals activate NLRP3 inflammasomes in atherogenesis models, and DSS-induced intestinal inflammation has been reported to involve NLRP3 inflammasome activity. However, experimental colitis studies also show context-dependent protective effects of NLRP3 inflammasome co
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-inflammatory agent 69 Related Classifications
HY-N8862 Related Classifications
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