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Cat. No.: HY-155731

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Antiviral agent 35

Antiviral agent 35 (compound 4d) is an orally active and potent influenza virus inhibitor, acting function in the early stage of virus replication. Antiviral agent 35 inhibits ROS accumulation, autophagy and apoptosis induced by influenza virus, and also inhibits inflammatory response mediated by RIG-1 pathway in mouse model with pulmonary infection. Antiviral agent 35 shows little cytotoxicity with CC₅₀ >800 μM in MDCK cells, and anti-H1N1 (A/Weiss/43) activity with EC₅₀ of 2.28 μM.

For research use only. We do not sell to patients.

CAS No.: 2760972-52-7
Formula: C₂₃H₁₈N₂O₄S
Molecular Weight:418.47

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

Antiviral agent 35 Chemical Structure

CAS No.: 2760972-52-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

EC50: 2.28 μM (HINI A/Weiss/43), 3.34 μM (A/Virginia/ATCC2/2009), 6.61 μM (A/Califomia/2014)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
MDCK	CC₅₀	>800 μM Compound: 4d	Cytotoxicity against dog MDCK cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against dog MDCK cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 37517205]

In Vitro

Antiviral agent 35 (compound 4d) (25 μM, 50 μM; 24-72 h) inhibits influenza virus replication in MDCK cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Antiviral agent 35 (compound 4d) (25 mg/kg/d, 50 mg/kg/d, 100 mg/kg/d; by gavage; 2-6 d) attenuates pulmonary inflammation in mice on the 2nd, 4th and 6th day after H1N1 infection^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2760972-52-7
Molecular Weight 418.47
Formula C₂₃H₁₈N₂O₄S
SMILES

O=[N+](C1=CC=C(C=C1)S(=O)(N(C2=CC=CC3=C2C=CC=C3)CC4=CC=CC=C4)=O)[O-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ge Y, et al. Synthesis and pharmacodynamic evaluation of naphthalene derivatives against influenza A virus in vitro and in vivo. Eur J Med Chem. 2023 Nov 5;259:115660. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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