1. Anti-infection
  2. Influenza Virus
  3. Antiviral agent 35

Antiviral agent 35 (compound 4d) is an orally active and potent influenza virus inhibitor, acting function in the early stage of virus replication. Antiviral agent 35 inhibits ROS accumulation, autophagy and apoptosis induced by influenza virus, and also inhibits inflammatory response mediated by RIG-1 pathway in mouse model with pulmonary infection. Antiviral agent 35 shows little cytotoxicity with CC50 >800 μM in MDCK cells, and anti-H1N1 (A/Weiss/43) activity with EC50 of 2.28 μM.

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Antiviral agent 35 Chemical Structure

Antiviral agent 35 Chemical Structure

CAS No. : 2760972-52-7

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Description

Antiviral agent 35 (compound 4d) is an orally active and potent influenza virus inhibitor, acting function in the early stage of virus replication. Antiviral agent 35 inhibits ROS accumulation, autophagy and apoptosis induced by influenza virus, and also inhibits inflammatory response mediated by RIG-1 pathway in mouse model with pulmonary infection. Antiviral agent 35 shows little cytotoxicity with CC50 >800 μM in MDCK cells, and anti-H1N1 (A/Weiss/43) activity with EC50 of 2.28 μM[1].

IC50 & Target

EC50: 2.28 μM (HINI A/Weiss/43), 3.34 μM (A/Virginia/ATCC2/2009), 6.61 μM (A/Califomia/2014)[1]

In Vitro

Antiviral agent 35 (compound 4d) (25 μM, 50 μM; 24-72 h) inhibits influenza virus replication in MDCK cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Antiviral agent 35 (compound 4d) (25 mg/kg/d, 50 mg/kg/d, 100 mg/kg/d; by gavage; 2-6 d) attenuates pulmonary inflammation in mice on the 2nd, 4th and 6th day after H1N1 infection[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

418.47

Formula

C23H18N2O4S

CAS No.
SMILES

O=[N+](C1=CC=C(C=C1)S(=O)(N(C2=CC=CC3=C2C=CC=C3)CC4=CC=CC=C4)=O)[O-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Antiviral agent 35 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Antiviral agent 35
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HY-155731
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