2. Neuronal Signaling Membrane Transporter/Ion Channel Metabolic Enzyme/Protease
  3. nAChR Endogenous Metabolite
  4. Glycerophosphoinositol choline

Glycerophosphoinositol choline is an essential nutrient that activates alpha7 nicotinic receptors and has analgesic and anti-inflammatory activity. Glycerophosphoinositol choline can affect diseases such as liver disease, atherosclerosis and neurological disorders.

For research use only. We do not sell to patients.

Glycerophosphoinositol choline Chemical Structure

Glycerophosphoinositol choline Chemical Structure

CAS No. : 425642-32-6

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Other In-stock Forms of Glycerophosphoinositol choline:

Other Forms of Glycerophosphoinositol choline:

Glycerophosphoinositol choline Related Antibodies

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Description

Glycerophosphoinositol choline is an essential nutrient that activates alpha7 nicotinic receptors and has analgesic and anti-inflammatory activity. Glycerophosphoinositol choline can affect diseases such as liver disease, atherosclerosis and neurological disorders[1][2].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Glycerophosphoinositol choline (0 or 70 μM, 4 days) can effectively mitigate apoptosis and maintain cell viability[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Glycerophosphoinositol choline Related Antibodies

Cell Viability Assay[1]

Cell Line: Rat pheochromocytoma cells PC12
Concentration: 0 or 70 μM
Incubation Time: 4 days
Result: Showed the cell viability of 94% at 70 μM while cell viability of 83% at 0 μM.
Reduced the number of cells with DNA breaks (characteristic of apoptosis) by 8.5% at 70 μM compared to the no treatment group.
In Vivo

Glycerophosphoinositol choline (s.c., 0.2 and 100 mg/kg/h, 24 or 48 hours) can reduce postoperative injurious reflexes and effectively decreases tumor necrosis factor (TNF) release from macrophages in female C57/Bl6 mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Postoperative pain model of female C57/Bl6 mice[2]
Dosage: 0.2 and 100 mg/kg/h
Administration: Subcutaneous injection, 24 or 48 hours
Result: Reduced heat hypersensitivity after surgery with maximal efficacy after 48 h treatment and the ED50 value of choline dose was 1.7 mg/kg/h.
Reduced hypersensitivity to punctate mechanical stimuli 48 hours after infusion in a dose-dependent manner and with the ED50 value of 4.7 mg/kg/h but not 24 hours.
Clinical Trial
Molecular Weight

437.38

Formula

C14H32NO12P
CAS No.
SMILES

C[N+](C)(C)CCO.OC[C@@H](O)COP(O[C@H]1[C@@H]([C@H]([C@@H]([C@H]([C@H]1O)O)O)O)O)([O-])=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Glycerophosphoinositol choline Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Glycerophosphoinositol425642-32-6nAChREndogenous MetaboliteNicotinic acetylcholine receptorscholinealpha7 nicotinic receptoranalgesicanti-inflammatoryInhibitorinhibitorinhibit

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