1. Immunology/Inflammation
  2. COX
  3. Lornoxicam

Lornoxicam (Synonyms: Chlortenoxicam; Ro 13-9297; TS110)

Cat. No.: HY-B0367 Purity: 98.31%
Handling Instructions

Lornoxicam, a COX-1 and COX-2 inhibitor, is a new nonsteroidal anti-inflammatory drug (NSAID).

For research use only. We do not sell to patients.

Lornoxicam Chemical Structure

Lornoxicam Chemical Structure

CAS No. : 70374-39-9

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10 mM * 1 mL in DMSO USD 79 In-stock
Estimated Time of Arrival: December 31
100 mg USD 72 In-stock
Estimated Time of Arrival: December 31
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Description

Lornoxicam, a COX-1 and COX-2 inhibitor, is a new nonsteroidal anti-inflammatory drug (NSAID). Target: COX Lornoxicam showed a balanced inhibition of COX-1/-2 exhibiting the lowest IC50 (0.005 microM/0.008 microM) of the large panel of NSAIDs tested. lornoxicam showed a marked inhibition of IL-6 formation (IC50 54 microM) while the formation ofTNF-alpha, IL-1beta and IL-8 was only moderately affected [1]. Lornoxicam is effective in the treatment of patients with activated osteoarthritis; the analgesic and anti-inflammatory effects of lornoxicam are significantly superior to those of rofecoxib without inferiority in tolerability [2]. Lornoxicam was fully effective for prevention of hyperalgesia [3].

IC50 & Target

COX-1

5 nM (IC50, in cells)

COX-2

45 nM (IC50, in cells)

Clinical Trial
Molecular Weight

371.82

Formula

C₁₃H₁₀ClN₃O₄S₂

CAS No.

70374-39-9

SMILES

O=C(C1=C(O)C2=C(C=C(Cl)S2)S(N1C)(=O)=O)NC3=NC=CC=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 3.8 mg/mL (10.22 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6895 mL 13.4474 mL 26.8947 mL
5 mM 0.5379 mL 2.6895 mL 5.3789 mL
10 mM 0.2689 mL 1.3447 mL 2.6895 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

LornoxicamChlortenoxicamRo 13-9297TS110TS 110TS-110COXCyclooxygenaseInhibitorinhibitorinhibit

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Lornoxicam
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