1. Metabolic Enzyme/Protease
  2. Drug Metabolite
  3. 4'-Hydroxy diclofenac

4'-Hydroxy diclofenac 

Cat. No.: HY-15550 Purity: >97.0%
Handling Instructions

4'-Hydroxy diclofenac is an orally active metabolite of Diclofenac (HY-15036) by cytochrome P450 2C9 (CYP2C9). 4'-Hydroxy diclofenac has anti-inflammatory and analgesic properties.

For research use only. We do not sell to patients.

4'-Hydroxy diclofenac Chemical Structure

4'-Hydroxy diclofenac Chemical Structure

CAS No. : 64118-84-9

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Description

4'-Hydroxy diclofenac is an orally active metabolite of Diclofenac (HY-15036) by cytochrome P450 2C9 (CYP2C9). 4'-Hydroxy diclofenac has anti-inflammatory and analgesic properties[1][2].

In Vivo

A single oral administration of Diclofenac to humanized mice, the unchanged drug in plasma peaks at 0.25 hour and then declines with a half-life (t1/2) of 2.4 hours. 4'-Hydroxy diclofenac also peaks at 0.25 hour and is undetectable within 24 hours. The plasma concentration of unchanged 4'-Hydroxy diclofenac peaks at 0.25 hour and declines rapidly in Humanized chimeric mice received of 4'-Hydroxy diclofenac (10 mg/kg; a single oral)[2].

Molecular Weight

312.15

Formula

C₁₄H₁₁Cl₂NO₃

CAS No.

64118-84-9

SMILES

O=C(O)CC1=CC=CC=C1NC2=C(Cl)C=C(O)C=C2Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

References

Purity: >97.0%

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Keywords:

4'-Hydroxy diclofenacDrug MetaboliteorallyDiclofenaccytochromeP4502C9CYP2C9anti-inflammatoryanalgesicInhibitorinhibitorinhibit

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4'-Hydroxy diclofenac
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HY-15550
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