4'-Hydroxy diclofenac-d4
Based on 1 Customer Validation
4'-Hydroxy diclofenac-d4 is the deuterium labeled 4'-Hydroxy diclofenac. 4'-Hydroxy diclofenac is an orally active metabolite of Diclofenac (HY-15036) by cytochrome P450 2C9 (CYP2C9). 4'-Hydroxy diclofenac has anti-inflammatory and analgesic properties.
For research use only. We do not sell to patients.
- Purity: 98.92%
- CAS No.: 254762-27-1
- Formula: C14H7D4Cl2NO3
- Molecular Weight:316.17
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 254762-27-1
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Unlabeled Cas 64118-84-9
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Appearance Solid
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Molecular Weight 316.17
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Formula C14H7D4Cl2NO3
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Color White to light yellow
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SMILES
ClC(C=C(C=C1Cl)O)=C1NC2=C(C([2H])=C([2H])C([2H])=C2[2H])CC(O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMF : ≥ 30 mg/mL (94.89 mM)
Ethanol : ≥ 30 mg/mL (94.89 mM)
DMSO : ≥ 30 mg/mL (94.89 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (420 KB)
- English - EN (420 KB)
- Français - FR (420 KB)
- Deutsch - DE (420 KB)
- Norwegian - NO (420 KB)
- Español - ES (420 KB)
- Swedish - SV (420 KB)
- Italian - IT (420 KB)
- Korean - KR (420 KB)
- Portuguese - PT (420 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. J Shimamoto, et al. Lack of Differences in Diclofenac (A Substrate for CYP2C9) Pharmacokinetics in Healthy Volunteers With Respect to the Single CYP2C9*3 Allele. Eur J Clin Pharmacol. 2000 Apr;56(1):65-8. [Content Brief]
[3]. Hidetaka Kamimura, et al. Formation of the Accumulative Human Metabolite and Human-Specific Glutathione Conjugate of Diclofenac in TK-NOG Chimeric Mice With Humanized Livers. Drug Metab Dispos. 2015 Mar;43(3):309-16. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMF / Ethanol / DMSO | 1 mM | 3.1629 mL | 15.8143 mL | 31.6286 mL | 79.0714 mL |
| 5 mM | 0.6326 mL | 3.1629 mL | 6.3257 mL | 15.8143 mL | |
| 10 mM | 0.3163 mL | 1.5814 mL | 3.1629 mL | 7.9071 mL | |
| 15 mM | 0.2109 mL | 1.0543 mL | 2.1086 mL | 5.2714 mL | |
| 20 mM | 0.1581 mL | 0.7907 mL | 1.5814 mL | 3.9536 mL | |
| 25 mM | 0.1265 mL | 0.6326 mL | 1.2651 mL | 3.1629 mL | |
| 30 mM | 0.1054 mL | 0.5271 mL | 1.0543 mL | 2.6357 mL | |
| 40 mM | 0.0791 mL | 0.3954 mL | 0.7907 mL | 1.9768 mL | |
| 50 mM | 0.0633 mL | 0.3163 mL | 0.6326 mL | 1.5814 mL | |
| 60 mM | 0.0527 mL | 0.2636 mL | 0.5271 mL | 1.3179 mL | |
| 80 mM | 0.0395 mL | 0.1977 mL | 0.3954 mL | 0.9884 mL |
4'-Hydroxy diclofenac-d4 Related Classifications
HY-15550S Related Classifications
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