4'-Hydroxy diclofenac-d₄

Name: 4'-Hydroxy diclofenac-d 4
Brand: MedChemExpress
SKU: HY-15550S
Rating: 4.5 (1 reviews)

Cat. No.: HY-15550S: FAQs
Data Sheet SDS COA Handling Instructions

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4'-Hydroxy diclofenac-d₄ is the deuterium labeled 4'-Hydroxy diclofenac. 4'-Hydroxy diclofenac is an orally active metabolite of Diclofenac (HY-15036) by cytochrome P450 2C9 (CYP2C9). 4'-Hydroxy diclofenac has anti-inflammatory and analgesic properties[1][2].

For research use only. We do not sell to patients.

4'-Hydroxy diclofenac-d<sub>4</sub> Chemical Structure

4'-Hydroxy diclofenac-d₄ Chemical Structure

CAS No. : 254762-27-1

Size	Price	Stock	Quantity
1 mg	USD 240	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 600	Get quote	Estimated Time of Arrival: December 31
10 mg	USD 1020	Get quote	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of 4'-Hydroxy diclofenac-d₄:

4'-Hydroxy diclofenac In-stock

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Biological Activity
Purity & Documentation
References
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Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

316.17

Formula

C₁₄H₇D₄Cl₂NO₃

CAS No.

254762-27-1

Appearance

Solid

Color

White to light yellow

SMILES

ClC(C=C(C=C1Cl)O)=C1NC2=C(C([2H])=C([2H])C([2H])=C2[2H])CC(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (316.29 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.1629 mL	15.8143 mL	31.6286 mL
5 mM	0.6326 mL	3.1629 mL	6.3257 mL
10 mM	0.3163 mL	1.5814 mL	3.1629 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.48%

Select Batch:

Data Sheet (275 KB) SDS (0 KB)

COA (253 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. J Shimamoto, et al. Lack of Differences in Diclofenac (A Substrate for CYP2C9) Pharmacokinetics in Healthy Volunteers With Respect to the Single CYP2C9*3 Allele. Eur J Clin Pharmacol. 2000 Apr;56(1):65-8. [Content Brief]

[3]. Hidetaka Kamimura, et al. Formation of the Accumulative Human Metabolite and Human-Specific Glutathione Conjugate of Diclofenac in TK-NOG Chimeric Mice With Humanized Livers. Drug Metab Dispos. 2015 Mar;43(3):309-16. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.1629 mL	15.8143 mL	31.6286 mL	79.0714 mL
	5 mM	0.6326 mL	3.1629 mL	6.3257 mL	15.8143 mL
	10 mM	0.3163 mL	1.5814 mL	3.1629 mL	7.9071 mL
	15 mM	0.2109 mL	1.0543 mL	2.1086 mL	5.2714 mL
	20 mM	0.1581 mL	0.7907 mL	1.5814 mL	3.9536 mL
	25 mM	0.1265 mL	0.6326 mL	1.2651 mL	3.1629 mL
	30 mM	0.1054 mL	0.5271 mL	1.0543 mL	2.6357 mL
	40 mM	0.0791 mL	0.3954 mL	0.7907 mL	1.9768 mL
	50 mM	0.0633 mL	0.3163 mL	0.6326 mL	1.5814 mL
	60 mM	0.0527 mL	0.2636 mL	0.5271 mL	1.3179 mL
	80 mM	0.0395 mL	0.1977 mL	0.3954 mL	0.9884 mL
	100 mM	0.0316 mL	0.1581 mL	0.3163 mL	0.7907 mL